scholarly journals Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1739 ◽  
Author(s):  
Alessandro Allegra ◽  
Alessandro Tonacci ◽  
Giovanni Pioggia ◽  
Caterina Musolino ◽  
Sebastiano Gangemi
Keyword(s):  
Molecular Mechanisms ◽  
Clinical Effectiveness ◽  
Rosmarinus Officinalis ◽  
New Drugs ◽  
Neoplastic Diseases ◽  
Natural Substances ◽  
Anticancer Effects ◽  
Collateral Effects ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Alternative treatments for neoplastic diseases with new drugs are necessary because the clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural substances of plant origin have been demonstrated to be successful in the prevention and treatment of numerous tumors. Rosmarinus officinalis L. is a herb that is cultivated in diverse areas of the world. There is increasing attention being directed towards the pharmaceutical capacities of rosemary, utilized for its anti-inflammatory, anti-infective or anticancer action. The antitumor effect of rosemary has been related to diverse mechanisms, such as the antioxidant effect, antiangiogenic properties, epigenetic actions, regulation of the immune response and anti-inflammatory response, modification of specific metabolic pathways, and increased expression of onco-suppressor genes. In this review, we aim to report the results of preclinical studies dealing with the anticancer effects of rosemary, the molecular mechanisms related to these actions, and the interactions between rosemary and anticancer drugs. The prospect of utilizing rosemary as an agent in the treatment of different neoplastic diseases is discussed. However, although the use of rosemary in the therapy of neoplasms constitutes a fascinating field of study, large and controlled studies must be conducted to definitively clarify the real impact of this substance in clinical practice.

Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies

2018 ◽  
Vol 26 (4) ◽  
pp. 1057-1080 ◽  
Author(s):  
Raphaelle Sousa Borges ◽  
Hady Keita ◽  
Brenda Lorena Sánchez Ortiz ◽  
Tafnis Ingret dos Santos Sampaio ◽  
Irlon Maciel Ferreira ◽  
...  
Keyword(s):  
Essential Oil ◽  
Rosmarinus Officinalis ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

scholarly journals In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions

2019 ◽  
Vol 125 ◽  
pp. 214-220 ◽  
Author(s):  
A.E. Karadağ ◽  
B. Demirci ◽  
A. Çaşkurlu ◽  
F. Demirci ◽  
M.E. Okur ◽  
...  
Keyword(s):  
Rosmarinus Officinalis ◽  
Flower Extract ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain

2017 ◽  
Vol 86 ◽  
pp. 441-449 ◽  
Author(s):  
Mahboobeh Ghasemzadeh Rahbardar ◽  
Bahareh Amin ◽  
Soghra Mehri ◽  
Seyed Javad Mirnajafi-Zadeh ◽  
Hossein Hosseinzadeh
Keyword(s):  
Neuropathic Pain ◽  
Rat Model ◽  
Rosmarinic Acid ◽  
Ethanolic Extract ◽  
Rosmarinus Officinalis ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Rosmarinus officinalis L. extract ameliorates intestinal inflammation through MAPKs/NF-κB signaling in a murine model of acute experimental colitis

2016 ◽  
Vol 7 (7) ◽  
pp. 3233-3243 ◽  
Author(s):  
Kanakaraju Medicherla ◽  
Avanee Ketkar ◽  
Bidya Dhar Sahu ◽  
Godi Sudhakar ◽  
Ramakrishna Sistla
Keyword(s):  
Murine Model ◽  
Intestinal Inflammation ◽  
Experimental Colitis ◽  
Rosmarinus Officinalis ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Anti-inflammatory and anti-colitis effects of Rosmarinus officinalis L. extract (RE).

Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review

2021 ◽  
pp. 107815522098484
Author(s):  
Yaschilal Muche Belayneh ◽  
Gedefew Getnet Amare ◽  
Birhanu Geta Meharie
Keyword(s):  
Colorectal Cancer ◽  
Molecular Mechanisms ◽  
Vascular Endothelial ◽  
Akt Activation ◽  
Dna Repair Mechanisms ◽  
Anticancer Effects ◽  
Cancer Review ◽  
Repair Mechanisms ◽  
Anti Inflammatory ◽  
Endothelial Growth Factor

Colorectal cancer is one of the commonest malignancies worldwide. The estimated lifetime risk of the disease is about 5% with an incidence of one million new cases and 600,000 deaths worldwide every year. It is estimated that in 2019, approximately 134,490 new cases of colorectal cancer will be diagnosed with 49,190 mortalities. Though the disease is regarded as a disorder of the more developed world, the occurrence is steadily increasing in many developing countries. Since chronic inflammation is a known aggravating risk factor for colorectal cancer, anti-inflammatory agents such as aspirin have been used to prevent the development of colorectal cancer and related mortality. The potential mechanisms for the effect of aspirin in the prevention of colorectal cancer have been proposed and broadly classified as cyclooxygenase (COX) dependent and COX-independent. Some of the primary effectors of COX-dependent mechanisms in carcinogenesis are likely to be prostaglandins. In contrast to the reversible action of other nonsteroidal anti-inflammatory drugs, aspirin is known to irreversibly inactivate COX enzymes to suppress production of prostaglandins. COX-independent mechanisms of anticancer effects of aspirin include down-regulation of nuclear factor kappa B activity and Akt activation, modulation of Bcl-2 and Bax family proteins, suppression of vascular endothelial growth factor, induction of apoptosis, disruption of DNA repair mechanisms, and induction of spermidine/spermine N1-acetyltransferase that modulates polyamine catabolism.

scholarly journals Imiquimod: the biochemical mechanisms of immunomodulatory and anti-inflammatory activity

2013 ◽  
Vol 59 (3) ◽  
pp. 249-266 ◽  
Author(s):  
S.V. Bozrova ◽  
V.A. Levitsky ◽  
S.A. Nedospasov ◽  
M.S. Drutskaya
Keyword(s):  
Molecular Mechanisms ◽  
Experimental Studies ◽  
Direct Interaction ◽  
Cyclic Adenosine Monophosphate ◽  
Clinical Effectiveness ◽  
Adenosine Monophosphate ◽  
New Drugs ◽  
Published Data ◽  
Biochemical Basis ◽  
Immune Modulators

Imidazoquinolins represent a new group of compounds that recently entered into clinical practice as anti-tumor and anti-viral immune modulators. They are low molecular weight synthetic guanosine-like molecules. Although imiquimod, the most widely used imidazoquinolin, is recommended for the treatment of several forms of skin cancer and papillomas, the molecular mechanisms of its action are not fully understood. In particular, imiquimod has been characterized as a specific agonist of Toll-like receptor 7 (TLR7) and is widely used in this capacity in a large number of experimental studies and clinical trials. However, detailed analysis of the published data with the use of imiquimod, suggests that its biological activity can not be explained only by interaction with TLR7. There are indications of a direct interaction of imiquimod with adenosine receptors and other molecules that regulate the synthesis of cyclic adenosine monophosphate. A detailed understanding of the biochemical basis of imiquimod immunomodulating and antitumor effect will increase its clinical effectiveness and accelerate the development of new drugs with similar but improved medical properties. This review summarizes the published data concerning the effects of imiquimod on a variety of intracellular biochemical processes and signaling pathways.

scholarly journals Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Myrna Déciga-Campos ◽  
Karla Lizet Beltrán-Villalobos ◽  
Hidemi Aguilar-Mariscal ◽  
María Eva González-Trujano ◽  
Guadalupe Esther Ángeles-López ◽  
...  
Keyword(s):  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Rosmarinus Officinalis ◽  
Syzygium Aromaticum ◽  
Response Curves ◽  
Pharmacological Interaction ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

The use of alternative medicine to treat pain has been increased, and the combination of several medicinal plants for its relief is a common practice in traditional medicine. The present study is aimed at determining whether a combination of Syzygium aromaticum (S. aromaticum) and Rosmarinus officinalis L. (R. officinalis) potentiates their antinociceptive and anti-inflammatory effects. These effects were explored using the formalin and carrageenan assays in rats, respectively. Animals received local pretreatment with S. aromaticum oil or R. officinalis ethanolic extract (0.1–100 μg/paw) alone or combined in a 1 : 1 rate. Concentration-response curves were built to compare pharmacological responses after an individual administration of S. aromaticum, R. officinalis, or their combination. The pharmacological interaction was investigated by an isobolographic study using the EC50 of each component in a fixed 1 : 1 ratio. S. aromaticum and R. officinalis administered alone showed significant and concentration-dependent antinociceptive and anti-inflammatory effects, but R. officinalis was more potent than S. aromaticum in both the antinociceptive and anti-inflammatory effects (EC50 = 7.96 ± 0.6 μg/paw vs. EC50 = 41.6 ± 1.7 μg/paw; EC50 = 1.97 ± 0.3 μg/paw vs. EC50 = 26.9 ± 2.5 μg/paw, respectively). The isobolographic analysis of the combination of these species in a 1 : 1 ratio showed a synergistic interaction between S. aromaticum and R. officinalis since Zmix (experimental value) was lower than Zadd (theoretical value) for both the antinociceptive effect (Zmix = 0.45 ± 0.1 < Zadd = 24.8 ± 1.3) and the anti-inflammatory effect (Zmix = 5.2 ± 0.6 < Zadd = 14.4 ± 2.2), suggesting a potentiation for both pharmacological effects. These results prove evidence of the efficacy of mixture herb-herb used in folk medicine for pain therapy. It also emphasizes the requirement of pharmacological studies to explore the efficacy and safety of herb interactions.

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