Rosmarinus officinalis L. extract ameliorates intestinal inflammation through MAPKs/NF-κB signaling in a murine model of acute experimental colitis

2016 ◽  
Vol 7 (7) ◽  
pp. 3233-3243 ◽  
Author(s):  
Kanakaraju Medicherla ◽  
Avanee Ketkar ◽  
Bidya Dhar Sahu ◽  
Godi Sudhakar ◽  
Ramakrishna Sistla
Keyword(s):  
Murine Model ◽  
Intestinal Inflammation ◽  
Experimental Colitis ◽  
Rosmarinus Officinalis ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Anti-inflammatory and anti-colitis effects of Rosmarinus officinalis L. extract (RE).

Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies

2018 ◽  
Vol 26 (4) ◽  
pp. 1057-1080 ◽  
Author(s):  
Raphaelle Sousa Borges ◽  
Hady Keita ◽  
Brenda Lorena Sánchez Ortiz ◽  
Tafnis Ingret dos Santos Sampaio ◽  
Irlon Maciel Ferreira ◽  
...  
Keyword(s):  
Essential Oil ◽  
Rosmarinus Officinalis ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

scholarly journals In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions

2019 ◽  
Vol 125 ◽  
pp. 214-220 ◽  
Author(s):  
A.E. Karadağ ◽  
B. Demirci ◽  
A. Çaşkurlu ◽  
F. Demirci ◽  
M.E. Okur ◽  
...  
Keyword(s):  
Rosmarinus Officinalis ◽  
Flower Extract ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

scholarly journals Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice

2012 ◽  
Vol 303 (1) ◽  
pp. G71-G82 ◽  
Author(s):  
Nancy M. Benight ◽  
Barbara Stoll ◽  
Juan C. Marini ◽  
Douglas G. Burrin
Keyword(s):  
Time Course ◽  
Intestinal Inflammation ◽  
Tissue Injury ◽  
Experimental Colitis ◽  
Therapeutic Benefit ◽  
The Body ◽  
Myeloperoxidase Activity ◽  
Matrix Remodeling ◽  
Inflammatory Models ◽  
Anti Inflammatory

Methylthioadenosine (MTA) is a precursor of the methionine salvage pathway and has been shown to have anti-inflammatory properties in various models of acute and chronic inflammation. However, the anti-inflammatory properties of MTA in models of intestinal inflammation are not defined. We hypothesized that orally administered MTA would be bioavailable and reduce morbidity associated with experimental colitis. We examined clinical, histological, and molecular markers of disease in mice provided oral MTA before (preventative) or after (therapy) the induction of colitis with 3% dextran sulfate sodium (DSS). We found a reduction in disease activity, weight loss, myeloperoxidase activity, and histological damage in mice given preventative MTA compared with DSS alone. We also found that equivalent supplementation with methionine could not reproduce the anti-inflammatory effects of MTA, and that MTA had no detectable adverse effects in control or DSS mice. Expression microarray analysis of colonic tissue showed several dominant pathways related to inflammatory cytokines/chemokines and extracellular matrix remodeling were upregulation by DSS and suppressed in MTA-supplemented mice. MTA is rapidly absorbed in the gastrointestinal tract and disseminated throughout the body, based on a time course analysis of an oral bolus of MTA. This effect is transient, with MTA levels falling to near baseline within 90 min in most organs. Moreover, MTA did not lead to increased blood or tissue methionine levels, suggesting that its effects are specific. However, MTA provided limited therapeutic benefit when administered after the onset of colitis. Our results show that oral MTA supplementation is a safe and effective strategy to prevent inflammation and tissue injury associated with DSS colitis in mice. Additional studies in chronic inflammatory models are necessary to determine if MTA is a safe and beneficial option for the maintenance of remission in human inflammatory bowel disease.

Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain

2017 ◽  
Vol 86 ◽  
pp. 441-449 ◽  
Author(s):  
Mahboobeh Ghasemzadeh Rahbardar ◽  
Bahareh Amin ◽  
Soghra Mehri ◽  
Seyed Javad Mirnajafi-Zadeh ◽  
Hossein Hosseinzadeh
Keyword(s):  
Neuropathic Pain ◽  
Rat Model ◽  
Rosmarinic Acid ◽  
Ethanolic Extract ◽  
Rosmarinus Officinalis ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

scholarly journals Peroxisome Proliferator-Activated Receptor Alpha Mediates the Beneficial Effects of Atorvastatin in Experimental Colitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Paulo José Basso ◽  
Helioswilton Sales-Campos ◽  
Viviani Nardini ◽  
Murillo Duarte-Silva ◽  
Vanessa Beatriz Freitas Alves ◽  
...  
Keyword(s):  
Intestinal Inflammation ◽  
Experimental Colitis ◽  
Predictive Biomarker ◽  
Peroxisome Proliferator ◽  
Dependent Manner ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Anti Inflammatory

The current therapeutic options for Inflammatory Bowel Diseases (IBD) are limited. Even using common anti-inflammatory, immunosuppressive or biological therapies, many patients become unresponsive to the treatments, immunosuppressed or unable to restrain secondary infections. Statins are cholesterol-lowering drugs with non-canonical anti-inflammatory properties, whose underlying mechanisms of action still remain poorly understood. Here, we described that in vitro atorvastatin (ATO) treatment was not toxic to splenocytes, constrained cell proliferation and modulated IL-6 and IL-10 production in a dose-dependent manner. Mice exposed to dextran sulfate sodium (DSS) for colitis induction and treated with ATO shifted their immune response from Th17 towards Th2, improved the clinical and histological aspects of intestinal inflammation and reduced the number of circulating leukocytes. Both experimental and in silico analyses revealed that PPAR-α expression is reduced in experimental colitis, which was reversed by ATO treatment. While IBD patients also downregulate PPAR-α expression, the responsiveness to biological therapy relied on the restoration of PPAR-α levels. Indeed, the in vitro and in vivo effects induced by ATO treatment were abrogated in Ppara-/- mice or leukocytes. In conclusion, the beneficial effects of ATO in colitis are dependent on PPAR-α, which could also be a potential predictive biomarker of therapy responsiveness in IBD.

scholarly journals Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Myrna Déciga-Campos ◽  
Karla Lizet Beltrán-Villalobos ◽  
Hidemi Aguilar-Mariscal ◽  
María Eva González-Trujano ◽  
Guadalupe Esther Ángeles-López ◽  
...  
Keyword(s):  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Rosmarinus Officinalis ◽  
Syzygium Aromaticum ◽  
Response Curves ◽  
Pharmacological Interaction ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

The use of alternative medicine to treat pain has been increased, and the combination of several medicinal plants for its relief is a common practice in traditional medicine. The present study is aimed at determining whether a combination of Syzygium aromaticum (S. aromaticum) and Rosmarinus officinalis L. (R. officinalis) potentiates their antinociceptive and anti-inflammatory effects. These effects were explored using the formalin and carrageenan assays in rats, respectively. Animals received local pretreatment with S. aromaticum oil or R. officinalis ethanolic extract (0.1–100 μg/paw) alone or combined in a 1 : 1 rate. Concentration-response curves were built to compare pharmacological responses after an individual administration of S. aromaticum, R. officinalis, or their combination. The pharmacological interaction was investigated by an isobolographic study using the EC50 of each component in a fixed 1 : 1 ratio. S. aromaticum and R. officinalis administered alone showed significant and concentration-dependent antinociceptive and anti-inflammatory effects, but R. officinalis was more potent than S. aromaticum in both the antinociceptive and anti-inflammatory effects (EC50 = 7.96 ± 0.6 μg/paw vs. EC50 = 41.6 ± 1.7 μg/paw; EC50 = 1.97 ± 0.3 μg/paw vs. EC50 = 26.9 ± 2.5 μg/paw, respectively). The isobolographic analysis of the combination of these species in a 1 : 1 ratio showed a synergistic interaction between S. aromaticum and R. officinalis since Zmix (experimental value) was lower than Zadd (theoretical value) for both the antinociceptive effect (Zmix = 0.45 ± 0.1 < Zadd = 24.8 ± 1.3) and the anti-inflammatory effect (Zmix = 5.2 ± 0.6 < Zadd = 14.4 ± 2.2), suggesting a potentiation for both pharmacological effects. These results prove evidence of the efficacy of mixture herb-herb used in folk medicine for pain therapy. It also emphasizes the requirement of pharmacological studies to explore the efficacy and safety of herb interactions.

scholarly journals Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1739 ◽  
Author(s):  
Alessandro Allegra ◽  
Alessandro Tonacci ◽  
Giovanni Pioggia ◽  
Caterina Musolino ◽  
Sebastiano Gangemi
Keyword(s):  
Molecular Mechanisms ◽  
Clinical Effectiveness ◽  
Rosmarinus Officinalis ◽  
New Drugs ◽  
Neoplastic Diseases ◽  
Natural Substances ◽  
Anticancer Effects ◽  
Collateral Effects ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Alternative treatments for neoplastic diseases with new drugs are necessary because the clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural substances of plant origin have been demonstrated to be successful in the prevention and treatment of numerous tumors. Rosmarinus officinalis L. is a herb that is cultivated in diverse areas of the world. There is increasing attention being directed towards the pharmaceutical capacities of rosemary, utilized for its anti-inflammatory, anti-infective or anticancer action. The antitumor effect of rosemary has been related to diverse mechanisms, such as the antioxidant effect, antiangiogenic properties, epigenetic actions, regulation of the immune response and anti-inflammatory response, modification of specific metabolic pathways, and increased expression of onco-suppressor genes. In this review, we aim to report the results of preclinical studies dealing with the anticancer effects of rosemary, the molecular mechanisms related to these actions, and the interactions between rosemary and anticancer drugs. The prospect of utilizing rosemary as an agent in the treatment of different neoplastic diseases is discussed. However, although the use of rosemary in the therapy of neoplasms constitutes a fascinating field of study, large and controlled studies must be conducted to definitively clarify the real impact of this substance in clinical practice.

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