scholarly journals Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Nutrients ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 731 ◽  
Author(s):  
Jessy Moore ◽  
Michael Yousef ◽  
Evangelia Tsiani
Keyword(s):  
Rosmarinus Officinalis ◽  
Rosemary Extract ◽  
Anticancer Effects ◽  
Rosmarinus Officinalis L

scholarly journals Effect of Rosemary (Rosmarinus officinalis L.) Supplementation on Probiotic Yoghurt: Physicochemical Properties, Microbial Content, and Sensory Attributes

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2393
Author(s):  
Haider I. Ali ◽  
Mithun Dey ◽  
Azalldeen Kazal Alzubaidi ◽  
Sadiq Jaafir Aziz Alneamah ◽  
Ammar B. Altemimi ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Bifidobacterium Longum ◽  
Sensory Attributes ◽  
Rosmarinus Officinalis ◽  
Sensory Properties ◽  
Lactobacillus Delbrueckii ◽  
Rosemary Extract ◽  
Total Phenolic ◽  
Study Results ◽  
Rosmarinus Officinalis L

Rosemary (Rosmarinus officinalis L.) is a natural aromatic plant that belongs to the family of Lamiaceae. The rosemary plant has been utilized to preserve food due to its ability to prevent oxidation and microbial contamination. This study aimed to investigate the effect of fortifying yoghurt with rosemary extracts and probiotic bacteria (LAB) (Bifidobacterium longum ATCC15707 and two lactic acid bacteria, Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus) on its chemical composition, total phenolic compounds, antioxidant capacity, and sensory properties. The study results revealed significant differences in the total solids, protein, and ash content when rosemary concentration increased beyond 2%. However, there were no significant differences among the treatments in acidity and pH value. The sensory evaluation results indicated that the addition of aqueous extract of rosemary affected the sensory properties of yoghurt (flavour, body and texture, appearance, and overall grade), wherein an increasing concentration of rosemary extract increased score of flavour, body and texture, appearance, and overall grade. On the other hand, rosemary extract did not affect the sensory properties and chemical composition. To sum up, it can be stated that rosemary was used in the preparation of yoghurt with increased health benefits, acceptable sensory attributes, and the production of synbiotic yogurt.

scholarly journals The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Fawzi Mohammad Al Sheyab ◽  
Nizar Abuharfeil ◽  
Lina Salloum ◽  
Rehan Bani Hani ◽  
Dalal Saleh Awad
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coconut Oil ◽  
Normal Diet ◽  
Rosmarinus Officinalis ◽  
Immunoglobulin M ◽  
Rosemary Extract ◽  
Control Group ◽  
Immunomodulatory Activity ◽  
Rosmarinus Officinalis L

The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(- 68.57%), low density lipoprotein (LDL) (- 56.34%), and triglycerides (TG) (- 182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

Attenuation of allergen‐mediated mast cell activation by rosemary extract ( Rosmarinus officinalis L.)

2020 ◽  
Vol 107 (5) ◽  
pp. 843-857
Author(s):  
Michael Yousef ◽  
Robert W.E. Crozier ◽  
Natalie J. Hicks ◽  
Colton J.F. Watson ◽  
Tylar Boyd ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Rosmarinus Officinalis ◽  
Mast Cell Activation ◽  
Rosemary Extract ◽  
Rosmarinus Officinalis L

scholarly journals Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1739 ◽  
Author(s):  
Alessandro Allegra ◽  
Alessandro Tonacci ◽  
Giovanni Pioggia ◽  
Caterina Musolino ◽  
Sebastiano Gangemi
Keyword(s):  
Molecular Mechanisms ◽  
Clinical Effectiveness ◽  
Rosmarinus Officinalis ◽  
New Drugs ◽  
Neoplastic Diseases ◽  
Natural Substances ◽  
Anticancer Effects ◽  
Collateral Effects ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Alternative treatments for neoplastic diseases with new drugs are necessary because the clinical effectiveness of chemotherapy is often reduced by collateral effects. Several natural substances of plant origin have been demonstrated to be successful in the prevention and treatment of numerous tumors. Rosmarinus officinalis L. is a herb that is cultivated in diverse areas of the world. There is increasing attention being directed towards the pharmaceutical capacities of rosemary, utilized for its anti-inflammatory, anti-infective or anticancer action. The antitumor effect of rosemary has been related to diverse mechanisms, such as the antioxidant effect, antiangiogenic properties, epigenetic actions, regulation of the immune response and anti-inflammatory response, modification of specific metabolic pathways, and increased expression of onco-suppressor genes. In this review, we aim to report the results of preclinical studies dealing with the anticancer effects of rosemary, the molecular mechanisms related to these actions, and the interactions between rosemary and anticancer drugs. The prospect of utilizing rosemary as an agent in the treatment of different neoplastic diseases is discussed. However, although the use of rosemary in the therapy of neoplasms constitutes a fascinating field of study, large and controlled studies must be conducted to definitively clarify the real impact of this substance in clinical practice.

scholarly journals Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice

2016 ◽  
Vol 21 (4) ◽  
pp. NP85-NP90 ◽  
Author(s):  
Mosayeb Noori Ahmad Abadi ◽  
Mohsen Mortazavi ◽  
Navid Kalani ◽  
Hadi Zare Marzouni ◽  
Wesam Kooti ◽  
...  
Keyword(s):  
Side Effects ◽  
Statistical Tests ◽  
Rosmarinus Officinalis ◽  
Rosemary Extract ◽  
Control Group ◽  
Standard Drug ◽  
Hydroalcoholic Extract ◽  
Plus Maze ◽  
Significant Difference ◽  
Rosmarinus Officinalis L

In today’s stressful world, psychopathy (especially anxiety) is receiving increased importance. Most of the drugs used to treat this disease have several side effects. Medicinal plants derived from natural products have fewer side effects and can be used in the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of Rosmarinus officinalis L. on anxiety in mice. In this experimental study, 50 male mice were randomly divided into 5 groups. To evaluate anxiety, the Elevated Plus Maze test was performed. The control group received normal saline, the positive control group received diazepam (1 mg/kg) as intraperitoneal injection, and the experimental groups received doses of 100, 200, and 400 mg/kg body weight of rosemary extract. The data were analyzed using SPSS 15 and ANOVA statistical tests. The results show that rosemary extract dose-dependently increases the mice spending time and the entries number of mice in plus maze open arms (indicating less stress). This effect at a dose of 400 mg/kg was similar to diazepam, which, in comparison to the control group, was statistically significant ( P < .01), while the evaluation of locomotor activity in treated groups, compared with the control groups, showed no significant difference ( P > .05). On the other hand, the rosemary extract, similar to the standard drug diazepam, showed an anti-anxiety effect. This effect is probably due to the presence of flavonoids in this plant and their antioxidant property.

scholarly journals Inhibition of allergen‐mediated mast cell activation by rosemary extract ( Rosmarinus officinalis L.)

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Michael Yousef ◽  
Natalie J. Hicks ◽  
Tylar Boyd ◽  
Evangelia Tsiani ◽  
Adam J. MacNeil
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Rosmarinus Officinalis ◽  
Mast Cell Activation ◽  
Rosemary Extract ◽  
Rosmarinus Officinalis L

scholarly journals Total protein level reduction of odontopathogens biofilms by Rosmarinus officinalis L. (rosemary) extract: an analysis on Candida albicans and Streptococcus mutans

2019 ◽  
Vol 22 (2) ◽  
pp. 260-266
Author(s):  
Jonatas Rafael De Oliveira ◽  
Gabriela de Fátima Santana-Melo ◽  
Samira Esteves Afonso Camargo ◽  
Luana Marotta Reis De Vasconcellos ◽  
Luciane Dias De Oliveira
Keyword(s):  
Candida Albicans ◽  
Streptococcus Mutans ◽  
Total Protein ◽  
Protein Level ◽  
Protein Composition ◽  
Rosmarinus Officinalis ◽  
Protein Quantification ◽  
Rosemary Extract ◽  
Total Protein Level ◽  
Rosmarinus Officinalis L

Objective: The resistance of fungi and bacteria to the available antimicrobials has increased and the development of alternative products to control them has become a very requirement. The use of plant products could be a viable option due to the efficacy, viability, and availability they present. Thereby, this study evaluated the effect of R. officinalis L. extract on C. albicans and S. mutans biofilms, by the total protein level analysis presented by the microorganisms. Material and Methods: For this purpose, monomicrobial biofilms were formed for 48 h and exposed to the R. officinalis L. extract for 5 min. Then, total protein quantification was performed by Lowry method. Results: The analysis showed significant total protein reduction of the biofilms after exposure to the plant extract, with 39 ± 11%, for C. albicans, and 32 ± 11%, for S. mutans. Conclusion: R. officinalis L. extract decreased the total protein level in both biofilms. Thus, C. albicans and S. mutans protein composition could be a target for action of antimicrobial agents.KeywordsBiofilms; Candida albicans; Proteins; Rosmarinus officinalis; Streptococcus mutans.

scholarly journals The Green Synthesis of MgO Nano-Flowers Using Rosmarinus officinalis L. (Rosemary) and the Antibacterial Activities against Xanthomonas oryzae pv. oryzae

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yasmine Abdallah ◽  
Solabomi Olaitan Ogunyemi ◽  
Amro Abdelazez ◽  
Muchen Zhang ◽  
Xianxian Hong ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Rosmarinus Officinalis ◽  
Xanthomonas Oryzae ◽  
Rosemary Extract ◽  
Cell Integrity ◽  
Bacterial Cell Death ◽  
Blight Disease ◽  
Rosmarinus Officinalis L

Recently, the use of herbs in the agriculture and food industry has increased significantly. In particular, Rosmarinus officinalis L. extracts have been reported to have strong antibacterial properties, which depend on their chemical composition. The present study displayed a biological method for synthesis of magnesium oxide (MgO) nano-flowers. The nano-flowers are developed without using any catalyst agent. Aqueous Rosemary extract was used to synthesize MgO nano-flowers (MgONFs) in stirring conditions and temperature at 70°C for 4 h. The mixture solution was checked by UV-Vis spectrum to confirm the presence of nanoparticles. The MgO nano-flowers powder was further characterized in this study by the X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. In addition, bacteriological tests indicated that MgO nano-flowers significantly inhibited bacterial growth, biofilm formation, and motility of Xanthomonas oryzae pv. oryzae, which is the causal agent of bacterial blight disease in rice. The electronic microscopic observation showed that bacterial cell death may be mainly due to destroy of cell integrity, resulting in leakage of intracellular content. As recommended, the use of Rosemary extract is an effective and green way to produce the MgO nano-flowers, which can be widely used in agricultural fields to suppress bacterial infection.

Sign in / Sign up

Export Citation Format

Share Document