scholarly journals Zinc Burden Evokes Copper Deficiency in the Hypoalbuminemic Hemodialysis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 577 ◽  
Author(s):  
Keizo Nishime ◽  
Morihiro Kondo ◽  
Kazuhiro Saito ◽  
Hisashi Miyawaki ◽  
Takahiko Nakagawa
Keyword(s):  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Acetate ◽  
Healthy Subjects ◽  
Copper Deficiency ◽  
Zinc Concentration ◽  
Zinc Level ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Upper Limit

Background: Recent research has focused on the roles of trace minerals such as zinc and copper. In 2017, oral zinc acetate was approved to treat zinc deficiency, and the next year, the Japanese Society for Clinical Nutrition developed the guidelines for diagnosis and treatment for zinc deficiency. Accordingly, hemodialysis patients began receiving zinc acetate when zinc deficiency was diagnosed. However, studies regarding the values of zinc and copper in hemodialysis patients are extremely poor, thus it remains unclear if the guidelines for healthy subjects can be applied to hemodialysis patients. Methods: We conducted a descriptive study, in which 132 patients were subjected to simply examine serum zinc concentration and its association with copper levels in hemodialysis patients (N = 65) versus healthy individuals attending a routine check-up (control group; N = 67) in our hospital. Analyses were performed with BellCurve for Excel (Social Survey Research Information Co., Ltd. Tokyo, Japan). Results: The distribution of zinc level in the hemodialysis group was distinct from that in the control group (P < 0.001). The zinc level was correlated with serum albumin concentration. Zinc concentration was also negatively correlated with serum copper level in both groups. In the hemodialysis group, the upper limit of zinc to avoid copper deficiency was 109.7 μg/dL, and the safety upper limit was 78.3 μg/dL. Conclusions: Hemodialysis patients exhibited a lower level of zinc concentration compared to normal healthy subjects. Since albumin binds to zinc as a carrier, low zinc levels could be attributed to lower level of serum albumin. Importantly, zinc and copper levels were inversely correlated, thus administration of oral zinc acetate could increase a risk for copper deficiency. It might be better to check both zinc and copper values monthly after prescribing zinc acetate.

scholarly journals Serum Zinc Deficiency in Squamous Cell Carcinomas of Oral and Maxillofacial Region: A Risk Factor to its Development and Metastasis

2020 ◽  
Author(s):  
Zhenq Xu ◽  
Jianw Shang ◽  
Guoq Wang ◽  
Li Long ◽  
Ping Zhang
Keyword(s):  
Zinc Deficiency ◽  
Squamous Cell ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Maxillofacial Region ◽  
Chi Square ◽  
Lymphnode Metastasis ◽  
Chi Square Test ◽  
Oral And Maxillofacial Region

Abstract Objectives To explore whether serum Zinc deficiency (sZnd) is a promoter to the development and lymphonode metastasis of squamous cell carcinoma (SCC) of oral and maxillofacial region (OMF). Methods 610 patients with SCC were enrolled in the study group, the controls consisted of the same number of age-gender matched subjects without cancers, serum Zinc level was tested in both groups. Characteristics of SCCs were investigated. Different concentration of serum Zinc and prevalence of sZnd between the two groups were calculated using Chi-square test. The association between serum Zinc status and SCC with different T-stages and lymphonode metastasis was focused on research. Results The patients varied from 19 to 87 years with a mean age of 58.89±10.91 years. Oral cavity was the most commonly affected region. Males were involved predominantly with a ratio of 1.44:1 to females. The concentration of serum Zinc in malignancies was 12.57±2.53 μmol/L, 19.2% suffered from sZnd; in the control group were 14.65±2.25 μmol/L and 6.1%. Decreased serum Zinc and increased prevalence of sZnd in SCC were statistically significant to controls (p=0.000) . Increased incidence of sZnd and reduced level of serum Zinc correlated significantly to the the progression and lymphnode metastasis of SCC (p<0.01). Conclusions sZnd was a predisposing indicator to the tumorigenesis of SCC and also a promoter to its aggravation and lymphonode metastasis, which should be considered as a factor in devising the treatment plannings.

scholarly journals P619 Efficacy of zinc acetate hydrate administration for zinc deficiency in patients with inflammatory bowel disease: a multi-centre retrospective study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S514-S515
Author(s):  
K Sakurai ◽  
T Katsurada ◽  
S Otagiri ◽  
K Yamanashi ◽  
K Nagashima ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Zinc Deficiency ◽  
Bowel Disease ◽  
Zinc Acetate ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Serum Zinc Concentration ◽  
Inflammatory Bowel ◽  
Acetate Hydrate ◽  
Observation Period

Abstract Background Zinc deficiency is common in patients with inflammatory bowel disease (IBD), and the frequency is about 42.1% in Crohn’s disease (CD) and 38.5% in ulcerative colitis (UC). Patients with IBD with serum zinc deficiency are more likely to have adverse disease-specific outcomes. However, there are few studies about the effect of administering zinc preparations in IBD patients with zinc deficiency. The purpose of this study was to investigate the efficacy of zinc acetate hydrate (Nobelzin®︎) preparation for patients with IBD with zinc deficiency. Methods 56 IBD patients who were treated with Nobelzin®︎ for zinc deficiency from March 2017 to November 2019 were analyzed. We conducted a multicenter retrospective observational study to investigate changes in serum zinc concentration or changes in disease activity before and after administration and their contributing factors. Results Among 56 cases, 4 cases were excluded due to self-interruption of internal use, and 52 cases (39 cases of CD, 13 cases of UC) were included. The median observation period was 27.5 (13–47) weeks, the median serum zinc concentration before administration was 58.5 (50.8–65.3) μg/dl, and the average of starting dose of Nobelzin®︎ was 67.8±31.1 mg/day. Nobelzin®︎ administration normalised serum zinc concentration(Zn ≥80 μg/dl) in 94.2 % (49/52) of patients. The median administration period required for normalisation of serum zinc concentration was 5 (3–8) weeks. In the group of CD patients who achieved zinc normalisation, the median CDAI score significantly improved after the normalisation from 171.5 to 129.5 (p &lt; 0.001). Similarly, the partial Mayo score in the same group of UC significantly improved after the normalisation (p = 0.035). There were 77.6 % patients who did not have additional treatment without Nobelzin®︎ administration until zinc was normalised. In CD patients of this group, the median CDAI score significantly improved after the normalisation from 152 to 120 (p = 0.029). All 3 cases in which zinc normalisation was not achieved within the observation period were CD cases, and they had a history of multiple surgeries, changes in biologics, or a long medical history. In one patient, side effects of Nobelzin®︎ administration were observed and these were abdominal discomfort and nausea. During the observation period, serum copper concentration was measured in 27 patients after administration of Nobelzin®︎, and one patient presented with copper deficiency. Conclusion Our findings show that administration of zinc acetate hydrate preparations may be effective in improving zinc deficiency and contribute to improve disease activity in IBD patients with zinc deficiency.

Zinc deficiency is an independent risk factor for prehypertension in healthy subjects

2019 ◽  
pp. 1-6 ◽  
Author(s):  
Sara C. Nevárez-López ◽  
Luis E. Simental-Mendía ◽  
Fernando Guerrero-Romero ◽  
Jorge A. Burciaga-Nava
Keyword(s):  
Blood Pressure ◽  
Zinc Deficiency ◽  
Healthy Subjects ◽  
Serum Zinc ◽  
Control Group ◽  
Case Group ◽  
Zinc Levels ◽  
And Control ◽  
Control Study ◽  
Apparently Healthy

Abstract. Objective: To assess whether zinc deficiency is associated with prehypertension (preHTN) in apparently healthy subjects. Design: Apparently healthy women and men, aged 20 to 60 years were enrolled into a case-control study. Individuals with and without preHTN were allocated into the case and control groups, respectively. Hypertension, liver disease, renal disease, smoking, pregnancy, diabetes, malignancy, hypernatremia, hypomagnesemia, medical treatment, and use of supplements containing zinc were exclusion criteria. PreHTN was defined by systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) of 120–139 mmHg and/or of 80–89 mmHg, respectively, and the zinc deficiency by serum zinc levels < 74 μg/dL in men and < 70 μg/dL in women. Results: In total, 142 subjects (90 women and 52 men) were enrolled and allocated in the case (n = 71) and control (n = 71) groups. In the overall population, the frequency of zinc deficiency was 11.1%; individuals in the case group showed significant higher frequency of zinc deficiency as compared with the control group (16.9% vs 5.5%, p = 0.04). The logistic regression analysis showed a significant association between zinc deficiency and preHTN (OR = 4.61; 95% CI: 1.24–17.12, p = 0.02). Conclusion: Our results suggest that zinc deficiency is associated with the presence of preHTN in apparently healthy subjects.

Percentile values of serum zinc concentration and prevalence of its deficiency in Iranian children and adolescents: the CASPIAN-V study

2020 ◽  
Vol 33 (4) ◽  
pp. 525-531
Author(s):  
Bahar Azemati ◽  
Maliheh Khoramdad ◽  
Mostafa Qorbani ◽  
Hadith Rastad ◽  
Gita Shafiee ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Zinc Level ◽  
Specific Reference ◽  
P Value ◽  
Residential Areas ◽  
Serum Zinc Concentration ◽  
Iranian Children

AbstractBackgroundTo determine the prevalence of serum zinc deficiency and provide the age- and sex-specific percentile values of serum zinc in children and adolescents.MethodsWe used the gathered data through the CASPIAN-V study, a national survey conducted on 3500 students aged 7–18 years from 30 provinces of Iran. In this study, 1370 blood samples were selected randomly, and serum zinc concentration was measured using a Hitachi automated analyzer. Zinc deficiency was defined as a serum zinc level of less than 75 μg/dL. Age-sex specific reference percentile values were developed for serum zinc concentration.ResultsThe mean age of participants was 12.4 ± 3.0 years; 49.3% were girls and 73% were urban inhabitants. Mean (standard deviation [SD]) of serum zinc concentration was 107.23 (25.81) μg/dL with a significant sex difference; 109.03 ± 26.12 μg/dL for males compared to 105.41 ± 25.3 μg/dL for females (p = 0.009). The prevalence of subclinical zinc deficiency was 4.9% (95% confidence intervals [CI]: 3.0, 6.9) in children and adolescents. Both zinc deficient and sufficient groups were similar in terms of age, sex and residential areas (all p-value > 0.05). Overall, the 5th and 95th percentile values for serum zinc were 68.28 and 151.87 μg/dL, respectively. The value of all percentiles consistently decreased with age. The 10–99th percentile values for serum zinc were greater in boys than girls at all ages.ConclusionsNearly 5% of subjects had zinc deficiency. Age-sex specific percentile values were established for Iranian children and adolescents.

scholarly journals Anadara granosa substitution in feed to improve the zinc, protein of the feed, serum albumin, and body weight of malnourished rats

Food Research ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 132-139
Author(s):  
M. Solang ◽  
M. Adriani
Keyword(s):  
Body Weight ◽  
Serum Albumin ◽  
Protein Level ◽  
Zinc Level ◽  
Albumin Level ◽  
Control Group ◽  
Control Group Design ◽  
Protein Levels ◽  
Zinc Levels ◽  
Anadara Granosa

The objective of this paper was to evaluate zinc and protein feed levels of Anadara granosa flour substitution and its effect of feed on serum albumin and body weight of a malnourished rat (Rattus norvegicus). This study comprised two stages: 1) analysis of protein and zinc level of the feed, and 2) feed test on rat using separate sample pre–test and post-test control group design. The malnourished rat was treated with dried rice; the dried rice was substituted with 12.5%, 25%, and 50% of Anadara granosa flour. Further, at room temperature, the flour can be kept for six months. This study revealed that the Anadara granosa-substituted feed had zinc levels between 0.999 ppm - 2.296 ppm and protein levels of 14.81% - 26.39%. On the other hand, the non-substituted feed had 0.791 ppm of zinc, and the protein level was 8.46%. Provision of the feed substituted with Anadara granosa flour increased the albumin serum level (p = 0.000) and the bodyweight of malnourished rats significantly (p = 0.002). This study revealed that substitution of Anadara granosa flour in feed could improve the zinc and protein level of the feed, which in turn improved the growth of malnourished rats (as the albumin level and the bodyweight also improved).

Effects of different levels of zinc and phosphorus on the growth of subterranean clover (Trifolium subterraneum L.)

1963 ◽  
Vol 14 (2) ◽  
pp. 180 ◽  
Author(s):  
CR Millikan
Keyword(s):  
Root Growth ◽  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Subterranean Clover ◽  
Normal Growth ◽  
Trifolium Subterraneum ◽  
Zinc Level ◽  
Wide Range ◽  
Phosphate Treatment ◽  
High Phosphate

Four water culture experiments are described in which the effects of the addition of all combinations of graduated amounts of phosphorus and zinc on the growth of subterranean clover were studied.In the first experiment, the variety Dwalganup was used, and in the other experiments the varieties Clare and Edenhope. Varietal differences in the symptoms of zinc deficiency are described. Phosphorus toxicity symptoms occurred in the variety Clare but not in Edenhope. The effects of increases in zinc or phosphorus level, or both, on growth of top + root (T + R) and on percentage top are described. A highly significant variety x phosphorus interaction effect on T + R was recorded at adequate zinc levels, which indicated that the phosphorus requirement of Edenhope was considerably greater than that of Clare. By contrast, tolerance to high levels of zinc in the substrate was greater in Clare than in Edenhope. In the presence of added phosphate, the initial T + R response to small, but still insufficient, additions of zinc to the substrate occurred in root growth more than in top growth, whereas when a level of zinc adequate for normal growth was supplied, top growth of the plants benefited more than root growth. Highly significant zinc x phosphorus interaction effects on T + R occurred. No relationship existed between zinc concentration and the occurrence of zinc deficiency symptoms. The critical zinc level was not a point of narrow range, but included a wide range of values, depending on the age of the plants and the phosphate level. The depression in T + R induced by high phosphate when the zinc level was insufficient was not due to a decrease in zinc concentration resulting from the high phosphate treatment, but such plants gave a high value for the phosphorus/zinc ratio. The results suggest that zinc is essential to phosphate utilization by the plant. Evidence of redistribution of phosphorus from tops to roots, and of decreases in the total amount of phosphorus in phosphorus-deficient plants, was obtained in one experiment between days 27 and 60.

scholarly journals Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Koji Okamoto ◽  
...  
Keyword(s):  
Older Adults ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. Methods A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. Results At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = − 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. Conclusions Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

scholarly journals Zinc supplementation in children with asthma exacerbation

2016 ◽  
Vol 8 (4) ◽  
Author(s):  
Sanguansak Rerksuppaphol ◽  
Lakkana Rerksuppaphol
Keyword(s):  
Zinc Deficiency ◽  
Asthma Exacerbation ◽  
Standard Treatment ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Asthma Severity ◽  
Zinc Level ◽  
Control Group ◽  
Assessment Measure ◽  
Children With Asthma

Zinc deficiency has demonstrated an association with the risk of asthma. This study aimed to evaluate the efficacy of zinc supplementation in reducing the severity of childhood asthma exacerbation. A number of 42 children with asthma exacerbation admitted to the hospital were randomized to receive either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo in adjuvant to the standard treatment. The pediatric respiratory assessment measure (PRAM) was used to measure the asthma severity. The primary outcome was a change in asthma severity from the baseline to the end of study. The study found that PRAM score in the zinc group showed a more rapid decrease compared to the control group at the 24-hour (2.2±1.3 vs. 1.2±1.3; P=0.015) and 48-hour (3.4±2.0 vs. 2.2±1.8; P=0.042) intervals. At admission, overall mean serum zinc level was 63.8 mg/dL and 57.1% of children had zinc deficiency with no difference in prevalence between groups. PRAM scores did not differ between children with low and normal zinc status. In conclusion, zinc supplementation as the adjuvant therapy to the standard treatment during asthma exacerbation resulted in rapid lessening of severity.

scholarly journals Improved Swallowing Function after Zinc Supplementation in the Elderly

2020 ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Okamoto Koji ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
The Elderly ◽  
Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In elderly patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before.Methods: A total of 52 elderly subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured.Results: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = -0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the elderly who had comorbid dysphagia and zinc deficiency.Conclusions: Zinc deficiency is associated with compromised swallowing function in elderly patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in elderly patients with zinc deficiency.

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