scholarly journals Zinc supplementation in children with asthma exacerbation

2016 ◽  
Vol 8 (4) ◽  
Author(s):  
Sanguansak Rerksuppaphol ◽  
Lakkana Rerksuppaphol
Keyword(s):  
Zinc Deficiency ◽  
Asthma Exacerbation ◽  
Standard Treatment ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Asthma Severity ◽  
Zinc Level ◽  
Control Group ◽  
Assessment Measure ◽  
Children With Asthma

Zinc deficiency has demonstrated an association with the risk of asthma. This study aimed to evaluate the efficacy of zinc supplementation in reducing the severity of childhood asthma exacerbation. A number of 42 children with asthma exacerbation admitted to the hospital were randomized to receive either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo in adjuvant to the standard treatment. The pediatric respiratory assessment measure (PRAM) was used to measure the asthma severity. The primary outcome was a change in asthma severity from the baseline to the end of study. The study found that PRAM score in the zinc group showed a more rapid decrease compared to the control group at the 24-hour (2.2±1.3 vs. 1.2±1.3; P=0.015) and 48-hour (3.4±2.0 vs. 2.2±1.8; P=0.042) intervals. At admission, overall mean serum zinc level was 63.8 mg/dL and 57.1% of children had zinc deficiency with no difference in prevalence between groups. PRAM scores did not differ between children with low and normal zinc status. In conclusion, zinc supplementation as the adjuvant therapy to the standard treatment during asthma exacerbation resulted in rapid lessening of severity.

scholarly journals Serum Zinc Deficiency in Squamous Cell Carcinomas of Oral and Maxillofacial Region: A Risk Factor to its Development and Metastasis

2020 ◽  
Author(s):  
Zhenq Xu ◽  
Jianw Shang ◽  
Guoq Wang ◽  
Li Long ◽  
Ping Zhang
Keyword(s):  
Zinc Deficiency ◽  
Squamous Cell ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Maxillofacial Region ◽  
Chi Square ◽  
Lymphnode Metastasis ◽  
Chi Square Test ◽  
Oral And Maxillofacial Region

Abstract Objectives To explore whether serum Zinc deficiency (sZnd) is a promoter to the development and lymphonode metastasis of squamous cell carcinoma (SCC) of oral and maxillofacial region (OMF). Methods 610 patients with SCC were enrolled in the study group, the controls consisted of the same number of age-gender matched subjects without cancers, serum Zinc level was tested in both groups. Characteristics of SCCs were investigated. Different concentration of serum Zinc and prevalence of sZnd between the two groups were calculated using Chi-square test. The association between serum Zinc status and SCC with different T-stages and lymphonode metastasis was focused on research. Results The patients varied from 19 to 87 years with a mean age of 58.89±10.91 years. Oral cavity was the most commonly affected region. Males were involved predominantly with a ratio of 1.44:1 to females. The concentration of serum Zinc in malignancies was 12.57±2.53 μmol/L, 19.2% suffered from sZnd; in the control group were 14.65±2.25 μmol/L and 6.1%. Decreased serum Zinc and increased prevalence of sZnd in SCC were statistically significant to controls (p=0.000) . Increased incidence of sZnd and reduced level of serum Zinc correlated significantly to the the progression and lymphnode metastasis of SCC (p<0.01). Conclusions sZnd was a predisposing indicator to the tumorigenesis of SCC and also a promoter to its aggravation and lymphonode metastasis, which should be considered as a factor in devising the treatment plannings.

scholarly journals The Effect of Zinc Supplementation on Sleep Quality of ICU Nurses: A Double Blinded Randomized Controlled Trial

2017 ◽  
Vol 66 (4) ◽  
pp. 191-200 ◽  
Author(s):  
Afshin Gholipour Baradari ◽  
Abbas Alipour ◽  
Ali Mahdavi ◽  
Hassan Sharifi ◽  
Seyed Mahmood Nouraei ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Zinc Supplementation ◽  
Controlled Trial ◽  
Intervention Group ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Serum Zinc Level ◽  
Randomized Controlled

This study examined the effect of zinc supplementation on the sleep quality (SQ) of intensive care unit (ICU) nurses. In a double-blind, randomized controlled trial, 54 ICU nurses were randomly assigned to the intervention group ( n = 27) that received 220 mg zinc sulfate capsules every 72 hours for 1 month and the control group ( n = 26) that received placebo. Sleep quality of ICU nurses was measured by calculating the total quality sleep score using the Pittsburgh Sleep Quality Index (PSQI). The serum zinc level was a secondary outcome. All measurements were calculated at both baseline and 1 month after intervention. The total PSQI, subjective SQ, and sleep latency scores for the intervention group were significantly lower than the control group, which means that the SQ of ICU nurses in the intervention group improved from baseline. The serum zinc level of the intervention group at the end of the study was significantly higher than the control group, which means that zinc supplementation improved participants’ serum zinc level. Based on these findings, the researcher suggested that zinc supplementation could be associated with better SQ, subjective SQ, and sleep latency in this group of workers.

scholarly journals Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Koji Okamoto ◽  
...  
Keyword(s):  
Older Adults ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. Methods A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. Results At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = − 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. Conclusions Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

scholarly journals Improved Swallowing Function after Zinc Supplementation in the Elderly

2020 ◽  
Author(s):  
Yumika Seki ◽  
Kota Ishizawa ◽  
Tetsuya Akaishi ◽  
Michiaki Abe ◽  
Okamoto Koji ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
The Elderly ◽  
Zinc Level ◽  
Swallowing Function ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In elderly patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before.Methods: A total of 52 elderly subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured.Results: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = -0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the elderly who had comorbid dysphagia and zinc deficiency.Conclusions: Zinc deficiency is associated with compromised swallowing function in elderly patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in elderly patients with zinc deficiency.

scholarly journals Serum Zinc deficiency in squamous cell carcinomas of oral and maxillofacial region: a risk factor to its development and metastasis

2020 ◽  
Author(s):  
Zhenq Xu ◽  
Jianw Shang ◽  
Guoq Wang ◽  
Li Long ◽  
Ping Zhang
Keyword(s):  
Zinc Deficiency ◽  
Squamous Cell ◽  
Serum Zinc ◽  
Reference Interval ◽  
Zinc Level ◽  
Control Group ◽  
Maxillofacial Region ◽  
Chi Square ◽  
Lymphnode Metastasis ◽  
Oral And Maxillofacial Region

Abstract Background To explore whether serum Zinc deficiency (sZnd) is a promoter to the development and lymphonode metastasis of squamous cell carcinoma (SCC) of oral and maxillofacial region (OMF). Methods 610 patients with SCC were enrolled in the study group, the controls consisted of the same number of age-gender matched subjects without cancers, serum Zinc level (sZn) was tested in both groups and anyone whose sZn belowed reference interval was detected as having sZnd. Characteristics of SCCs were investigated. Different concentration of serum Zinc and prevalence of sZnd between the two groups were calculated using Chi-square test. The association between serum Zinc status and SCC with different T-stages and lymphonode metastasis was focused on research. Results The patients varied from 19 to 87 years with a mean age of 58.89±10.91 years. Oral cavity was the most commonly affected region. Males were involved predominantly with a ratio of 1.44:1 to females. The concentration of sZn in malignancies was 12.57±2.53 μmol/L, 17.87% suffered from sZnd; in the control group were 14.65±2.25 μmol/L and 4.75%. Decreased sZn and increased prevalence of sZnd in SCC were statistically significant to controls (p=0.000) . Increased incidence of sZnd and reduced level of sZn correlated significantly to the the progression and lymphnode metastasis of SCC (p<0.01).Conclusions sZnd was a possible predisposing indicator to the tumorigenesis of SCC and also a promoter to its aggravation and lymphonode metastasis, which should be considered as a factor in devising the treatment plannings.

scholarly journals Evaluation of serum zinc level and IL-18 mRNA expression in children with pneumonia

2021 ◽  
Vol 67 (3) ◽  
pp. 168-171
Author(s):  
Shixiong Yang ◽  
Jin Shi
Keyword(s):  
Mrna Expression ◽  
Zinc Deficiency ◽  
Internal Control ◽  
Serum Zinc ◽  
Rna Isolation ◽  
Zinc Level ◽  
Control Group ◽  
Healthy Children ◽  
Serum Zinc Level ◽  
Zinc Levels

Pneumonia is currently one of the leading causes of death in children. Increased susceptibility to pneumonia may be due to their decreased immunity. One of the reasons for the decrease in immunity is zinc deficiency. In children with pneumonia, on the other hand, some cytokines are secreted, resulting in inflammation that spreads, persists, and makes treatment difficult for specialists. In this study, we investigated the serum zinc level in children with pneumonia and healthy children. Also, we tried to find its relationship with IL-18 mRNA expression as an inflammatory cytokine. For this purpose, serum zinc levels and IL-18 mRNA expression were evaluated in 120 children aged 3-60 months with pneumonia and 120 healthy children. After taking 2ml of blood from children and measuring serum zinc level, the level of the IL-18 mRNA was measured by real-time PCR. Total RNA was extracted by bioZOL™-G RNA Isolation Reagent kit. The primary cDNA was amplified by the extracted RNA, and in the next step, 2µl of cDNA were amplified by specific primers to measure IL-18 mRNA. The Beta-actin gene was also used as internal control and housekeeping gene. Results showed that the level of zinc in the patient group was 412.625±28.87?M and in the control group was 514.40±49.67?M. This difference was statistically significant (P=0.0053). Also, the expression of the IL-18 gene was increased in children with pneumonia, significantly (P=0.0015). Therefore, from the results, it can be deduced that children with zinc deficiency were at higher risk for a lung infection. Inflammatory cytokines such as IL-18 also were increased in these children. Hence, it can be concluded that zinc levels can reduce the expression of IL-18 mRNA and play an important role in the prevention and treatment of children with pneumonia.

scholarly journals Acute Diarrhea in Exclusively Breast Fed Infants in relation to Zinc Level

2021 ◽  
Vol 15 (5) ◽  
pp. 1431-1435
Keyword(s):  
Zinc Deficiency ◽  
Acute Diarrhea ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Control Group ◽  
Control Group ◽  
Serum Zinc Level ◽  
Healthy Control ◽  
The Mean ◽  
Breast Fed

Background: Zinc deficiency is associated with alteration in gastrointestinal tract structure, function, and impaired immune function. Aim: To analyze the effects of zinc deficiency on the occurrence of acute diarrhea in exclusively breast-fed infants. Methods: In a case-control study, including a total of 72 exclusively breast-fed infants aged ≤ 6 months, 34 of them with acute diarrhea were in the study group and 38 infants as the healthy control group. Demographic characteristics of all infants and their parents were studied. Serum Zinc level was measured for all participants. Results: Zinc level had significant (p-value =0.000) differences between infants with acute diarrhea and the healthy control group. The mean serum zinc value ± SEM in children with acute diarrhea was 63.11 ± 1.7 which was significantly (p = 0.000) different from the mean serum zinc value ± SEM (78.6 ± 1.6) in healthy infants. A cut-off value 60.6μg/dl of total serum zinc level was significantly (p = 0.000) associated with a sensitivity of 100 % with the occurrence of acute diarrhea among exclusively breast-fed infants. Conclusions: Low serum zinc level is associated with the occurrence of acute diarrhea in exclusively breast-fed infants. A cutoff serum zinc value of 60.6 μg/dl has 100% sensitivity with the occurrence of acute diarrhea among breast-fed infants. Keywords: Zinc deficiency, diarrhea, infants, breastfeeding.

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

2020 ◽  
Vol 11 (1) ◽  
pp. e9-e9
Author(s):  
Zahra Lotfi ◽  
Abbas Ali Zeraati ◽  
Elaheh Dashti ◽  
Tina Zeraati ◽  
Maryam Arghiany ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Bacterial Infections ◽  
Critical Role ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Individuals ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
The Mean

Introduction: Systemic bacterial infections are a common cause of mortality and morbidity in hemodialysis patients. Zinc has a critical role in several immune system functions. Patients who have enough amounts of zinc are able to better face infections caused by various pathogens in comparison to those with zinc insufficiency Objective We sought to assess the role of zinc deficiency in dialysis-associated bacterial infections. Patients and Methods: Eighty-Three adult patients with end-stage renal disease (ESRD) on hemodialysis including 43 patients with bacterial infectious complications and 40 non-infected patients as well as 41 healthy individuals were enrolled. Clinical data, laboratory values including serum zinc level and imaging findings were collected. SPSS was utilized to analyze the data with a significance cutoff set at P < 0.05. Results: Out of 124 participants, 80 (64.51%) were males and 44 (35.49%) were females. The mean age of infected hemodialysis group, non-infected hemodialysis group, and healthy controls were 50.8 ± 16.25, 49.1 ± 18.1, and 56.3 ± 18.2 years, respectively. Catheter site infection (37.3%) and urinary tract infection (30.2%) were the most common infections. The mean serum zinc concentration was significantly lower in the infected patients, compared to non-infected patients and healthy individuals (P < 0.001). Conclusion: The ESRD patients on hemodialysis have lower serum zinc levels which are associated with increased risk of bacterial infection. The role of screening for zinc deficiency and use of supplemental zinc in these patients need to be studied.

scholarly journals Evaluation of oral functions of the stomatognathic system according to the levels of asthma severity

2012 ◽  
Vol 24 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Mariana San Jorge de Castro ◽  
Adyléia Aparecida Dalbo Contrera Toro ◽  
Eulália Sakano ◽  
José Dirceu Ribeiro
Keyword(s):  
Persistent Asthma ◽  
Asthma Severity ◽  
Control Group ◽  
Healthy Children ◽  
Structural Part ◽  
Assessment Protocol ◽  
Group I ◽  
Study Results ◽  
Children With Asthma ◽  
Asthma Group

PURPOSE: To compare the orofacial functions (chewing, swallowing and speech) in children with asthma and healthy children. METHODS: A cross sectional study including 54 children of both genders with ages between 7 and 10 years was conducted. Twenty-seven of these subjects composed the experimental group, and were subdivided into two severity levels of asthma: Group I - mild intermittent and persistent asthma; Group II - persistent moderate to severe asthma. Twenty-seven healthy children were included in the control group (Group III). Speech-language pathology evaluation used the adapted Orofacial Myofunctional Assessment Protocol. Adaptation consisted in the exclusion of the structural part of the test, since this was not the aim of the study. The structural part was excluded because it was not the aim of this study. RESULTS: It was found alterations in oral functions, with significant differences between the three groups. These alterations showed no correlation with asthma severity, since the highest rate of alterations was found in Group I (mild asthma). CONCLUSION: Regardless of the severity level, children with asthma have altered patterns of chewing, swallowing and speech.

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