scholarly journals A zinc acetate hydrate preparation increased serum albumin levels and improved parameters related to renal anemia in hemodialysis patients with zinc deficiency

2020 ◽  
Vol 53 (5) ◽  
pp. 243-249
Author(s):  
Atsushi Fukui
Keyword(s):  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Acetate ◽  
Hemodialysis Patients ◽  
Renal Anemia ◽  
Acetate Hydrate

scholarly journals Zinc Burden Evokes Copper Deficiency in the Hypoalbuminemic Hemodialysis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 577 ◽  
Author(s):  
Keizo Nishime ◽  
Morihiro Kondo ◽  
Kazuhiro Saito ◽  
Hisashi Miyawaki ◽  
Takahiko Nakagawa
Keyword(s):  
Serum Albumin ◽  
Zinc Deficiency ◽  
Zinc Acetate ◽  
Healthy Subjects ◽  
Copper Deficiency ◽  
Zinc Concentration ◽  
Zinc Level ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Upper Limit

Background: Recent research has focused on the roles of trace minerals such as zinc and copper. In 2017, oral zinc acetate was approved to treat zinc deficiency, and the next year, the Japanese Society for Clinical Nutrition developed the guidelines for diagnosis and treatment for zinc deficiency. Accordingly, hemodialysis patients began receiving zinc acetate when zinc deficiency was diagnosed. However, studies regarding the values of zinc and copper in hemodialysis patients are extremely poor, thus it remains unclear if the guidelines for healthy subjects can be applied to hemodialysis patients. Methods: We conducted a descriptive study, in which 132 patients were subjected to simply examine serum zinc concentration and its association with copper levels in hemodialysis patients (N = 65) versus healthy individuals attending a routine check-up (control group; N = 67) in our hospital. Analyses were performed with BellCurve for Excel (Social Survey Research Information Co., Ltd. Tokyo, Japan). Results: The distribution of zinc level in the hemodialysis group was distinct from that in the control group (P < 0.001). The zinc level was correlated with serum albumin concentration. Zinc concentration was also negatively correlated with serum copper level in both groups. In the hemodialysis group, the upper limit of zinc to avoid copper deficiency was 109.7 μg/dL, and the safety upper limit was 78.3 μg/dL. Conclusions: Hemodialysis patients exhibited a lower level of zinc concentration compared to normal healthy subjects. Since albumin binds to zinc as a carrier, low zinc levels could be attributed to lower level of serum albumin. Importantly, zinc and copper levels were inversely correlated, thus administration of oral zinc acetate could increase a risk for copper deficiency. It might be better to check both zinc and copper values monthly after prescribing zinc acetate.

Evaluation of treatment with zinc acetate hydrate in patients with liver cirrhosis complicated by zinc deficiency

2020 ◽  
Vol 50 (4) ◽  
pp. 488-501
Author(s):  
Itaru Ozeki ◽  
Tomoaki Nakajima ◽  
Hirokazu Suii ◽  
Ryoji Tatsumi ◽  
Masakatsu Yamaguchi ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Zinc Deficiency ◽  
Zinc Acetate ◽  
Acetate Hydrate

scholarly journals P619 Efficacy of zinc acetate hydrate administration for zinc deficiency in patients with inflammatory bowel disease: a multi-centre retrospective study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S514-S515
Author(s):  
K Sakurai ◽  
T Katsurada ◽  
S Otagiri ◽  
K Yamanashi ◽  
K Nagashima ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Zinc Deficiency ◽  
Bowel Disease ◽  
Zinc Acetate ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Serum Zinc Concentration ◽  
Inflammatory Bowel ◽  
Acetate Hydrate ◽  
Observation Period

Abstract Background Zinc deficiency is common in patients with inflammatory bowel disease (IBD), and the frequency is about 42.1% in Crohn’s disease (CD) and 38.5% in ulcerative colitis (UC). Patients with IBD with serum zinc deficiency are more likely to have adverse disease-specific outcomes. However, there are few studies about the effect of administering zinc preparations in IBD patients with zinc deficiency. The purpose of this study was to investigate the efficacy of zinc acetate hydrate (Nobelzin®︎) preparation for patients with IBD with zinc deficiency. Methods 56 IBD patients who were treated with Nobelzin®︎ for zinc deficiency from March 2017 to November 2019 were analyzed. We conducted a multicenter retrospective observational study to investigate changes in serum zinc concentration or changes in disease activity before and after administration and their contributing factors. Results Among 56 cases, 4 cases were excluded due to self-interruption of internal use, and 52 cases (39 cases of CD, 13 cases of UC) were included. The median observation period was 27.5 (13–47) weeks, the median serum zinc concentration before administration was 58.5 (50.8–65.3) μg/dl, and the average of starting dose of Nobelzin®︎ was 67.8±31.1 mg/day. Nobelzin®︎ administration normalised serum zinc concentration(Zn ≥80 μg/dl) in 94.2 % (49/52) of patients. The median administration period required for normalisation of serum zinc concentration was 5 (3–8) weeks. In the group of CD patients who achieved zinc normalisation, the median CDAI score significantly improved after the normalisation from 171.5 to 129.5 (p &lt; 0.001). Similarly, the partial Mayo score in the same group of UC significantly improved after the normalisation (p = 0.035). There were 77.6 % patients who did not have additional treatment without Nobelzin®︎ administration until zinc was normalised. In CD patients of this group, the median CDAI score significantly improved after the normalisation from 152 to 120 (p = 0.029). All 3 cases in which zinc normalisation was not achieved within the observation period were CD cases, and they had a history of multiple surgeries, changes in biologics, or a long medical history. In one patient, side effects of Nobelzin®︎ administration were observed and these were abdominal discomfort and nausea. During the observation period, serum copper concentration was measured in 27 patients after administration of Nobelzin®︎, and one patient presented with copper deficiency. Conclusion Our findings show that administration of zinc acetate hydrate preparations may be effective in improving zinc deficiency and contribute to improve disease activity in IBD patients with zinc deficiency.

SP373THE EFFECT OF SUPPLEMENTATION WITH ZINC ACETATE HYDRATE FOR HYPOZINCEMIA ON RENAL ANEMIA

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Eiichi Sato ◽  
Manaka Degawa ◽  
Takao Ono ◽  
Hongmei Lu ◽  
Daisuke Matsumura ◽  
...  
Keyword(s):  
Zinc Acetate ◽  
Renal Anemia ◽  
Acetate Hydrate

scholarly journals Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients

2004 ◽  
Vol 66 (2) ◽  
pp. 841-848 ◽  
Author(s):  
Makoto Anraku ◽  
Kenichiro Kitamura ◽  
Ayumi Shinohara ◽  
Masataka Adachi ◽  
Ayaka Suenaga ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Intravenous Iron ◽  
Hemodialysis Patients ◽  
Iron Administration

scholarly journals Cytokine gene polymorphisms in hemodialysis patients: Association with comorbidity, functionality, and serum albumin

2004 ◽  
Vol 65 (4) ◽  
pp. 1449-1460 ◽  
Author(s):  
Vaidyanathapuram S. Balakrishnan ◽  
Daqing Guo ◽  
Madhumathi Rao ◽  
Bertrand L. Jaber ◽  
Hocine Tighiouart ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Gene Polymorphisms ◽  
Hemodialysis Patients ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

scholarly journals Efficacy of levocarnitine for renal anemia in hemodialysis patients

2014 ◽  
Vol 47 (2) ◽  
pp. 119-127
Author(s):  
Terumi Higuchi ◽  
Yumiko Ishikawa ◽  
Toshio Yamazaki ◽  
Mari Mizuno ◽  
Erina Okawa ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Renal Anemia
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