scholarly journals Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1379
Author(s):  
Gutiérrez-Román Ana Silvia ◽  
Trejo-Tapia Gabriela ◽  
Herrera-Ruiz Maribel ◽  
Monterrosas-Brisson Nayeli ◽  
Trejo-Espino José Luis ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Effective Dose ◽  
Mass Spectroscopy ◽  
Topical Application ◽  
Histological Analysis ◽  
Ear Edema ◽  
Aerial Parts ◽  
Inflammatory Parameter ◽  
Edema Model

In this study, we isolated from the aerial parts of Baccharis conferta Kunth (i) a new neoclerodane, denominated “bacchofertone”; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12-O-tetradecanoylforbol-13-acetate mice. Dichloromethane extract (BcD) exhibited 78.5 ± 0.72% inhibition of edema, followed by the BcD2 and BcD3 fractions of 71.4% and 82.9% respectively, at a dose of 1 mg/ear. Kingidiol and cirsimaritin were the most potent compounds identified, with a median effective dose of 0.12 and 0.16 mg/ear, respectively. A histological analysis showed that the topical application of TPA promoted intense cell infiltration, and this inflammatory parameter was reduced with the topical application of isolated compounds.

scholarly journals A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy

2019 ◽  
Vol 27 (4) ◽  
pp. 560-570 ◽  
Author(s):  
M.K.J. Jaggard ◽  
C.L. Boulangé ◽  
P. Akhbari ◽  
U. Vaghela ◽  
R. Bhattacharya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Small Molecule ◽  
Mass Spectroscopy ◽  
Nuclear Magnetic

Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance

1990 ◽  
Vol 36 (2) ◽  
pp. 225-229 ◽  
Author(s):  
K R Copeland ◽  
R W Yatscoff ◽  
R M McKenna
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Proton Nuclear Magnetic Resonance ◽  
Therapeutic Monitoring ◽  
Potency Ratio ◽  
Transplant Patients ◽  
In Vitro Systems ◽  
Nuclear Magnetic

Abstract Eight cyclosporine (CsA) metabolites were isolated from the urine of renal-transplant patients by high-pressure liquid chromatography. Structure and purity of the metabolites were assessed by fast atomic bombardment/mass spectroscopy, by proton nuclear magnetic resonance (NMR), and, when the quantity of metabolites permitted, by 13C-NMR. The immunosuppressive activities (I) of the metabolites were tested in three separate in vitro systems: primary and secondary mixed lymphocyte reactions as well as by a mitogen-stimulated system. The I, as measured by comparing the concentration of each metabolite required for 50% inhibition of incorporation of [3H] thymidine, varied among the assay systems, as did the ranking of I among the test systems. In general, the I of most metabolites in all assay systems were less than 10% of that for CsA. Metabolites with single modifications exhibited the greatest I; e.g., that of M-17 was congruent to 16% of that of CsA (potency ratio 0.16) in a secondary mixed lymphocyte reaction. The significance of these findings in relation to therapeutic monitoring of CsA is discussed.

scholarly journals Applications D'Intelligence Artificielle Dans La Chimie Organique. XVII. Nouveaux Programmes Du Projet SISTEMAT

1994 ◽  
Vol 12 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Vincente de Paulo Emerenciano ◽  
Gilberto do V. Rodrigues ◽  
Patricia A. T. Macari ◽  
Sandra A. Vesti ◽  
Joao H. G. Borges ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Natural Products ◽  
Magnetic Resonance ◽  
Data Base ◽  
Mass Spectroscopy ◽  
Nmr Spectra ◽  
Heuristic Rules ◽  
Structure Generation ◽  
Natural Products Chemistry ◽  
C Nmr

This work describes the new improvements of the SISlEMAT project, one system for structural elucidation mainly in the field of Natural Products Chemistry. Some examples of the resolution of problems using13C Nuclear Magnetic Resonance and Mass Spectroscopy are given. Programs to discover new heuristic rules for structure generation are discussed. The data base contains about 100013C NMR spectra.

scholarly journals Synthesis of Novel Spiro-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing

2021 ◽  
Vol 22 (12) ◽  
pp. 6251
Author(s):  
Yan-Cheng Liou ◽  
Yan-An Lin ◽  
Ke Wang ◽  
Juan-Cheng Yang ◽  
Yeong-Jiunn Jang ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Wound Healing ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Pharmacological Effects ◽  
One Pot ◽  
Reaction Method ◽  
X Ray ◽  
Wound Model ◽  
1H Nuclear Magnetic Resonance

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by 1H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

Metabolomics and protozoan parasites

2013 ◽  
Vol 58 (2) ◽  
Author(s):  
Timothy Paget ◽  
Nicolas Haroune ◽  
Sushmita Bagchi ◽  
Edward Jarroll
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Liquid Chromatography ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
State Of The Art ◽  
The State ◽  
Protozoan Parasites ◽  
Gas And Liquid Chromatography ◽  
Nuclear Magnetic

AbstractIn this review, we examine the state-of-the-art technologies (gas and liquid chromatography, mass spectroscopy and nuclear magnetic resonance, etc.) in the well-established area of metabolomics especially as they relate to protozoan parasites.

Polyprenols of Listeria monocytogenes

1973 ◽  
Vol 51 (6) ◽  
pp. 939-941 ◽  
Author(s):  
A. Vilim ◽  
M. C. Woods ◽  
K. K. Carroll
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Listeria Monocytogenes ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Nuclear Magnetic

Listeria monocytogenes was found to contain polyprenols in a concentration of 215 mg/kg of lyophilized bacteria. They consisted mainly of undecaprenol with a small amount of decaprenol. Characterization by infrared, nuclear magnetic resonance, and mass spectroscopy indicated that the undecaprenol had the same structure as that isolated from other bacteria.

scholarly journals Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 332 ◽  
Author(s):  
Zhongbin Cheng ◽  
Yuanli Li ◽  
Wan Liu ◽  
Lijun Liu ◽  
Jie Liu ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Deep Sea ◽  
Aspergillus Terreus ◽  
Positive Control ◽  
Inhibitory Effects ◽  
Etoac Extract ◽  
Ring Compounds ◽  
Ic50 Values

Three new butenolide derivatives, namely aspernolides N–P (1–3), together with six known analogues (4–9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1–3 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compound 1 represents the rare example of Aspergillus-derived butenolide derivatives featured by a monosubstituted benzene ring. Compounds 6–9 exhibited remarkable inhibitory effects against α-glucosidase with IC50 values of 3.87, 1.37, 6.98, and 8.06 μM, respectively, being much more active than the positive control acarbose (190.2 μM).

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