scholarly journals A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy

2019 ◽  
Vol 27 (4) ◽  
pp. 560-570 ◽  
Author(s):  
M.K.J. Jaggard ◽  
C.L. Boulangé ◽  
P. Akhbari ◽  
U. Vaghela ◽  
R. Bhattacharya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Small Molecule ◽  
Mass Spectroscopy ◽  
Nuclear Magnetic

Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance

1990 ◽  
Vol 36 (2) ◽  
pp. 225-229 ◽  
Author(s):  
K R Copeland ◽  
R W Yatscoff ◽  
R M McKenna
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Proton Nuclear Magnetic Resonance ◽  
Therapeutic Monitoring ◽  
Potency Ratio ◽  
Transplant Patients ◽  
In Vitro Systems ◽  
Nuclear Magnetic

Abstract Eight cyclosporine (CsA) metabolites were isolated from the urine of renal-transplant patients by high-pressure liquid chromatography. Structure and purity of the metabolites were assessed by fast atomic bombardment/mass spectroscopy, by proton nuclear magnetic resonance (NMR), and, when the quantity of metabolites permitted, by 13C-NMR. The immunosuppressive activities (I) of the metabolites were tested in three separate in vitro systems: primary and secondary mixed lymphocyte reactions as well as by a mitogen-stimulated system. The I, as measured by comparing the concentration of each metabolite required for 50% inhibition of incorporation of [3H] thymidine, varied among the assay systems, as did the ranking of I among the test systems. In general, the I of most metabolites in all assay systems were less than 10% of that for CsA. Metabolites with single modifications exhibited the greatest I; e.g., that of M-17 was congruent to 16% of that of CsA (potency ratio 0.16) in a secondary mixed lymphocyte reaction. The significance of these findings in relation to therapeutic monitoring of CsA is discussed.

Metabolomics and protozoan parasites

2013 ◽  
Vol 58 (2) ◽  
Author(s):  
Timothy Paget ◽  
Nicolas Haroune ◽  
Sushmita Bagchi ◽  
Edward Jarroll
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Liquid Chromatography ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
State Of The Art ◽  
The State ◽  
Protozoan Parasites ◽  
Gas And Liquid Chromatography ◽  
Nuclear Magnetic

AbstractIn this review, we examine the state-of-the-art technologies (gas and liquid chromatography, mass spectroscopy and nuclear magnetic resonance, etc.) in the well-established area of metabolomics especially as they relate to protozoan parasites.

Polyprenols of Listeria monocytogenes

1973 ◽  
Vol 51 (6) ◽  
pp. 939-941 ◽  
Author(s):  
A. Vilim ◽  
M. C. Woods ◽  
K. K. Carroll
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Listeria Monocytogenes ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Nuclear Magnetic

Listeria monocytogenes was found to contain polyprenols in a concentration of 215 mg/kg of lyophilized bacteria. They consisted mainly of undecaprenol with a small amount of decaprenol. Characterization by infrared, nuclear magnetic resonance, and mass spectroscopy indicated that the undecaprenol had the same structure as that isolated from other bacteria.

Friedel–Crafts rearrangements. III. Deuterium tracer studies of the mechanism of cyclialkylation of phenylalkyl chlorides

1968 ◽  
Vol 46 (21) ◽  
pp. 3315-3323 ◽  
Author(s):  
L. R. C. Barclay ◽  
E. C. Sanford
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Sodium Salt ◽  
Reaction Mechanisms ◽  
Malonic Ester ◽  
Primary Alcohols ◽  
Tracer Studies ◽  
Nuclear Magnetic

A series of dideuterated primary phenylalkyl chlorides 1-chloro-3-phenylpropane-2,2-d2 (4), 1-chloro-3-phenylpropane-1,1-d2 (9), 1-chloro-4-phenylbutane-2,2-d2 (8), 1-chloro-5-phenylpentane-4,4-d2 (5), 1-chloro-5-phenylpentane-3,3-d2 (6), and 1-chloro-5-phenylpentane-2,2-d2 (7) were synthesized by alkylations of malonic ester with phenylalkyl chlorides. Deuterium was introduced by exchange of the sodium salt of the alkylated malonic ester with D2O, followed by hydrolysis and decarboxylation. The resulting acids were reduced by hydride to primary alcohols and these were converted to the dideuterated primary chlorides by decomposition of the intermediate chlorosulfite esters. Nuclear magnetic resonance (n.m.r.) spectra confirmed the position of the deuterium in the chlorides. Friedel–Crafts cyclialkylation of the deuterated phenylpentyl chlorides yielded labelled 1-methyltetralins in which the label was located by n.m.r. and mass spectroscopy. The results demonstrated that rearrangement precedes cyclialkylation of 1-chloro-5-phenylpentane. Extensive deuterium scrambling between C-1, C-2, and C-3 accompanied the cyclialkylation of 5 but not that of 8. Reaction mechanisms are suggested to account for these results.

Lignin. XVI. Synthesis, Nuclear Magnetic Resonance, and Mass Spectroscopy of Several Monomeric and Dimeric Lignin-like Sulfonates

1973 ◽  
Vol 6 (1) ◽  
pp. 114-128 ◽  
Author(s):  
Wolfgang G. Glasser ◽  
Josef S. Gratzl ◽  
Juanita J. Collins ◽  
Kaj Forss ◽  
Joseph L. McCarthy
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Nuclear Magnetic
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