scholarly journals Synthesis of Novel Spiro-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing

2021 ◽  
Vol 22 (12) ◽  
pp. 6251
Author(s):  
Yan-Cheng Liou ◽  
Yan-An Lin ◽  
Ke Wang ◽  
Juan-Cheng Yang ◽  
Yeong-Jiunn Jang ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Wound Healing ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Pharmacological Effects ◽  
One Pot ◽  
Reaction Method ◽  
X Ray ◽  
Wound Model ◽  
1H Nuclear Magnetic Resonance

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by 1H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

Properties of perylene reacted with AsF5

1995 ◽  
Vol 73 (11-12) ◽  
pp. 653-657 ◽  
Author(s):  
W. R. Datars ◽  
T. R. Chien ◽  
P. K. Ummat
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Far Infrared ◽  
X Ray Diffraction ◽  
Sample Weight ◽  
X Ray ◽  
Semiconducting Properties ◽  
Orthorhombic Cell ◽  
Free Material

Perylene (Per) was reacted with AsF5 dissolved in liquid SO2 to produce Per(AsF6)2. Far infrared absorption showed absorption by AsF6−. Nuclear magnetic resonance of 19F consisted of a quartet formed by indirect nuclear–nuclear coupling. The change of mass through the reaction indicated the formula Per(AsF6)2. Mass spectroscopy showed bonding between perylene and F and indicated no SO2 solvent in the sample. This solvent-free material does not conduct electrically. X-ray diffraction showed that the structure has an orthorhombic cell. Exposure to air changes the sample weight and colour, and results in conduction with semiconducting properties and reduced bonding between AsF6− and perylene.

Iodide ion receptors: shape-persistent macrocycles of syn/anti Configurations

2021 ◽  
Author(s):  
Guang-Wei Zhang ◽  
Jia-Yin XIANG ◽  
Tao-Tao Zhong ◽  
Xin-Ru ZHI ◽  
Chuang Gao ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Single Crystal ◽  
1H Nmr ◽  
X Ray ◽  
Macrocyclic Receptors ◽  
Iodide Ion ◽  
1H Nuclear Magnetic Resonance ◽  
Ion Receptors ◽  
Nuclear Magnetic

This article reports a pair of rigid iodide ion macrocyclic receptors of syn/anti configurations. Single crystal X-ray analysis confirms the structure of the syn-isomers, 1H Nuclear Magnetic Resonance (1H NMR)...

Anhydrous uranyl crown-ether complexes. 1H nuclear magnetic resonance and x-ray study

1979 ◽  
Vol 34 ◽  
pp. 87-90 ◽  
Author(s):  
Gerard Folcher ◽  
Pierrette Charpin ◽  
Rose-Marie Costes ◽  
Nelly Keller ◽  
George C.de Villardi
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Crown Ether ◽  
X Ray ◽  
1H Nuclear Magnetic Resonance ◽  
Crown Ether Complexes ◽  
Nuclear Magnetic
Sign in / Sign up

Export Citation Format

Share Document