scholarly journals West Nile Virus and Usutu Virus Co-Circulation in Europe: Epidemiology and Implications

2019 ◽  
Vol 7 (7) ◽  
pp. 184 ◽  
Author(s):  
Zannoli ◽  
Sambri
Keyword(s):  
West Nile Virus ◽  
Human Health ◽  
Clinical Manifestations ◽  
Geographic Range ◽  
Vector Species ◽  
West Nile ◽  
Usutu Virus ◽  
Human Infections

West Nile virus (WNV) and Usutu virus (USUV) are neurotropic mosquito-borne flaviviruses that may infect humans. Although WNV is much more widespread and plays a much larger role in human health, the two viruses are characterized by similar envelope antigens, clinical manifestations, and present overlapping in terms of geographic range of transmission, host, and vector species. This review highlights some of the most relevant aspects of WNV and USUV human infections in Europe, and the possible implications of their co-circulation.

scholarly journals Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells

Viruses ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 882 ◽  
Author(s):  
Silvia Riccetti ◽  
Alessandro Sinigaglia ◽  
Giovanna Desole ◽  
Norbert Nowotny ◽  
Marta Trevisan ◽  
...  
Keyword(s):  
Stem Cells ◽  
West Nile Virus ◽  
Neural Stem Cells ◽  
Clinical Manifestations ◽  
Fetal Brain ◽  
Adult Brain ◽  
Interferon Response ◽  
Type I ◽  
West Nile ◽  
Usutu Virus

West Nile virus (WNV) and Usutu virus (USUV) are genetically related neurotropic mosquito-borne flaviviruses, which frequently co-circulate in nature. Despite USUV seeming to be less pathogenic for humans than WNV, the clinical manifestations induced by these two viruses often overlap and may evolve to produce severe neurological complications. The aim of this study was to investigate the effects of WNV and USUV infection on human induced pluripotent stem cell-derived neural stem cells (hNSCs), as a model of the neural progenitor cells in the developing fetal brain and in adult brain. Zika virus (ZIKV), a flavivirus with known tropism for NSCs, was used as the positive control. Infection of hNSCs and viral production, effects on cell viability, apoptosis, and innate antiviral responses were compared among viruses. WNV displayed the highest replication efficiency and cytopathic effects in hNSCs, followed by USUV and then ZIKV. In these cells, both WNV and USUV induced the overexpression of innate antiviral response genes at significantly higher levels than ZIKV. Expression of interferon type I, interleukin-1β and caspase-3 was significantly more elevated in WNV- than USUV-infected hNSCs, in agreement with the higher neuropathogenicity of WNV and the ability to inhibit the interferon response pathway.

scholarly journals Widespread Circulation of Flaviviruses in Horses and Birds in Northeastern Spain (Catalonia) between 2010 and 2019

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2404
Author(s):  
Sebastian Napp ◽  
Francisco Llorente ◽  
Cécile Beck ◽  
Eduard Jose-Cunilleras ◽  
Mercè Soler ◽  
...  
Keyword(s):  
West Nile Virus ◽  
One Health ◽  
Diagnostic Techniques ◽  
Serum Samples ◽  
West Nile ◽  
Usutu Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Human Infections ◽  
Microneutralization Test

The surveillance for West Nile virus (WNV) in Catalonia (northeastern Spain) has consistently detected flaviviruses not identified as WNV. With the aim of characterizing the flaviviruses circulating in Catalonia, serum samples from birds and horses collected between 2010 and 2019 and positive by panflavivirus competition ELISA (cELISA) were analyzed by microneutralization test (MNT) against different flaviviruses. A third of the samples tested were inconclusive by MNT, highlighting the limitations of current diagnostic techniques. Our results evidenced the widespread circulation of flaviviruses, in particular WNV, but also Usutu virus (USUV), and suggest that chicken and horses could serve as sentinels for both viruses. In several regions, WNV and USUV overlapped, but no significant geographical aggregation was observed. Bagaza virus (BAGV) was not detected in birds, while positivity to tick-borne encephalitis virus (TBEV) was sporadically detected in horses although no endemic foci were observed. So far, no human infections by WNV, USUV, or TBEV have been reported in Catalonia. However, these zoonotic flaviviruses need to be kept under surveillance, ideally within a One Health framework.

scholarly journals Co‐Infections: Simultaneous Detections of West Nile Virus and Usutu Virus in Birds from Germany

2021 ◽  
Author(s):  
Pauline Dianne Santos ◽  
Friederike Michel ◽  
Claudia Wylezich ◽  
Dirk Höper ◽  
Markus Keller ◽  
...  
Keyword(s):  
West Nile Virus ◽  
West Nile ◽  
Usutu Virus

scholarly journals Screening of Mosquitoes for West Nile Virus and Usutu Virus in Croatia, 2015–2020

2021 ◽  
Vol 6 (2) ◽  
pp. 45
Author(s):  
Ana Klobucar ◽  
Vladimir Savic ◽  
Marcela Curman Posavec ◽  
Suncica Petrinic ◽  
Urska Kuhar ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Culex Pipiens ◽  
Rt Pcr ◽  
West Nile ◽  
Usutu Virus ◽  
Culex Pipiens Complex ◽  
Mammalian Origin ◽  
Mosquito Pool ◽  
The City ◽  
Generation Sequencing

In the period from 2015 to 2020, an entomological survey for the presence of West Nile virus (WNV) and Usutu virus (USUV) in mosquitoes was performed in northwestern Croatia. A total of 20,363 mosquitoes were sampled in the City of Zagreb and Međimurje county, grouped in 899 pools and tested by real-time RT-PCR for WNV and USUV RNA. All pools were negative for WNV while one pool each from 2016 (Aedes albopictus), 2017 (Culex pipiens complex), 2018 (Cx. pipiens complex), and 2019 (Cx. pipiens complex), respectively, was positive for USUV. The 2018 and 2019 positive pools shared 99.31% nucleotide homology within the USUV NS5 gene and both clustered within USUV Europe 2 lineage. The next-generation sequencing of one mosquito pool (Cx. pipiens complex) collected in 2018 in Zagreb confirmed the presence of USUV and revealed several dsDNA and ssRNA viruses of insect, bacterial and mammalian origin.

Surveillance on antibodies against West Nile virus, Usutu virus, tick-borne encephalitis virus and Tribeč virus in wild birds in Drienovská wetland, Slovakia

Biologia ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 813-820 ◽  
Author(s):  
Tomáš Csank ◽  
Ľuboš Korytár ◽  
Terézia Pošiváková ◽  
Tamás Bakonyi ◽  
Juraj Pistl ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Wild Birds ◽  
Encephalitis Virus ◽  
West Nile ◽  
Usutu Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Increase in human West Nile and Usutu virus infections, Austria, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Stephan W. Aberle ◽  
Jolanta Kolodziejek ◽  
Christof Jungbauer ◽  
Karin Stiasny ◽  
Judith H. Aberle ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Blood Donation ◽  
Virus Infections ◽  
West Nile Fever ◽  
West Nile ◽  
Usutu Virus ◽  
Neuroinvasive Disease ◽  
Human West Nile Virus ◽  
Imported Cases

Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, six infections detected by blood donation screening and six imported cases. In addition, 18 cases of human Usutu virus infections (all blood donors) were recorded. This is the highest number of annual infections recorded in Austria since the introduction of both viruses.

scholarly journals Co-Circulation of West Nile and Usutu Flaviviruses in Mosquitoes in Slovakia, 2018

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 639 ◽  
Author(s):  
Viktória Čabanová ◽  
Silvie Šikutová ◽  
Petra Straková ◽  
Oldřich Šebesta ◽  
Bronislava Vichová ◽  
...  
Keyword(s):  
European Union ◽  
West Nile Virus ◽  
The European Union ◽  
West Nile ◽  
Usutu Virus ◽  
Pathogenic Viruses ◽  
Lineage 2 ◽  
First Time

Monitoring West Nile virus (WNV) and Usutu virus (USUV) activity now has the highest priority among mosquito-borne pathogenic viruses circulating in the European Union. This study documents a first time detection and the co-circulation of WNV lineage-2 (with the minimal prevalence of 0.46%) and USUV clade Europe 2 (with the minimal prevalence of 0.25%) in mosquitoes from the same habitat of south-western Slovakia and underlines necessity to perform rigorous surveillance in birds, mosquitoes, horses and humans in that country.

Detection of Usutu Virus Within a West Nile Virus Surveillance Program in Northern Italy

2011 ◽  
Vol 11 (5) ◽  
pp. 551-557 ◽  
Author(s):  
Marco Tamba ◽  
Paolo Bonilauri ◽  
Romeo Bellini ◽  
Mattia Calzolari ◽  
Alessandro Albieri ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Northern Italy ◽  
Surveillance Program ◽  
West Nile ◽  
Usutu Virus ◽  
Virus Surveillance

scholarly journals Protection of a Single Dose West Nile Virus Recombinant Subviral Particle Vaccine against Lineage 1 or 2 Strains and Analysis of the Cross-Reactivity with Usutu Virus

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108056 ◽  
Author(s):  
Teresa Merino-Ramos ◽  
Ana-Belén Blázquez ◽  
Estela Escribano-Romero ◽  
Rodrigo Cañas-Arranz ◽  
Francisco Sobrino ◽  
...  
Keyword(s):  
Single Dose ◽  
West Nile Virus ◽  
Cross Reactivity ◽  
West Nile ◽  
Usutu Virus ◽  
Virus Recombinant ◽  
The Cross ◽  
Subviral Particle

scholarly journals Co-circulation of Usutu virus and West Nile virus in a reed bed ecosystem

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Ivo Rudolf ◽  
Tamás Bakonyi ◽  
Oldřich Šebesta ◽  
Jan Mendel ◽  
Juraj Peško ◽  
...  
Keyword(s):  
West Nile Virus ◽  
West Nile ◽  
Usutu Virus ◽  
Reed Bed
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