scholarly journals Simulation Analysis of Improving Microfluidic Heterogeneous Immunoassay Using Induced Charge Electroosmosis on a Floating Gate

Micromachines ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 212 ◽  
Author(s):  
Qingming Hu ◽  
Yukun Ren ◽  
Weiyu Liu ◽  
Ye Tao ◽  
Hongyuan Jiang
Keyword(s):  
Simulation Analysis ◽  
Floating Gate ◽  
Induced Charge ◽  
Heterogeneous Immunoassay

Radiation Induced Charge Loss Mechanisms Across the Dielectrics of Floating Gate Flash Memories

2019 ◽  
Vol 6 (3) ◽  
pp. 807-843
Author(s):  
Giorgio Cellere ◽  
Andrea Cester ◽  
Alessandro Paccagnella
Keyword(s):  
Floating Gate ◽  
Flash Memories ◽  
Charge Loss ◽  
Radiation Induced ◽  
Induced Charge ◽  
Loss Mechanisms

scholarly journals A Numerical Investigation of Enhancing Microfluidic Heterogeneous Immunoassay on Bipolar Electrodes Driven by Induced-Charge Electroosmosis in Rotating Electric Fields

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 739
Author(s):  
Zhenyou Ge ◽  
Hui Yan ◽  
Weiyu Liu ◽  
Chunlei Song ◽  
Rui Xue ◽  
...  
Keyword(s):  
Electric Fields ◽  
Dimensional Space ◽  
Microfluidic Channel ◽  
Convective Transport ◽  
Base Flow ◽  
Working Fluid ◽  
Binding Reaction ◽  
Induced Charge ◽  
Heterogeneous Immunoassay ◽  
Floating Electrode

A unique approach is proposed to boost on-chip immuno-sensors, for instance, immunoassays, wherein an antibody immobilized on the walls of a microfluidic channel binds specifically to an antigen suspended freely within a working fluid. The performance of these sensors can be limited in both susceptibility and response speed by the slow diffusive mass transfer of the analyte to the binding surface. Under appropriate conditions, the binding reaction of these heterogeneous immuno-assays may be enhanced by electroconvective stirring driven by external AC electric fields to accelerate the translating motion of antigens towards immobilized antibodies. To be specific, the phenomenon of induced-charge electroosmosis in a rotating electric field (ROT-ICEO) is fully utilized to stir analyte in the vicinity of the functionalized surface of an ideally polarizable floating electrode in all directions inside a tri-dimensional space. ROT-ICEO appears as a consequence of the action of a circularly-polarized traveling wave signal on its own induced rotary Debye screening charge within a bipolar induced double layer formed on the central floating electrode, and thereby the pertinent electrokinetic streamlines exhibit a radially converging pattern that greatly facilitates the convective transport of receptor towards the ligand. Numerical simulations indicate that ROT-ICEO can enhance the antigen–antibody binding reaction more effectively than convectional nonlinear electroosmosis driven by standing wave AC signals. The effectiveness of ROT-ICEO micro-stirring is strongly dependent on the Damkohler number as well as the Peclet number if the antigens are carried by a continuous base flow. Our results provide a promising way for achieving a highly efficient heterogeneous immunoassay in modern micro-total-analytical systems.

scholarly journals Numerical modeling of radiation-induced charge loss in CMOS floating gate cells

Elektron ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 100-104
Author(s):  
Lucas Sambuco Salomone ◽  
Mariano Garcia-Inza ◽  
Sebastián Carbonetto ◽  
Adrián Faigón
Keyword(s):  
Numerical Modeling ◽  
Floating Gate ◽  
Charge Loss ◽  
Radiation Induced ◽  
Induced Charge

Mediante un modelo numérico desarrollado recientemente y basado en principios físicos, se estudia la respuesta a la radiación de celdas de compuerta flotante programadas/borradas. El rol que juega la captura de carga en los óxidos en el desplazamiento total de la tensión umbral con la dosis es debidamente evaluado a través de la variación de la tasa de captura de los huecos generados por radiación. Se considera un modelo analítico simplificado y se discuten sus limitaciones.

Computer simulation study about the dependence of amorphous silicon photonic waveguides efficiency on the material quality

2020 ◽  
Vol 90 (3) ◽  
pp. 30502
Author(s):  
Alessandro Fantoni ◽  
João Costa ◽  
Paulo Lourenço ◽  
Manuela Vieira
Keyword(s):  
Amorphous Silicon ◽  
High Throughput Screening ◽  
Simulation Analysis ◽  
Low Cost ◽  
Deposition Process ◽  
Large Area ◽  
Sidewall Roughness ◽  
Sensing Applications ◽  
Fabrication Defects ◽  
The Impact

Amorphous silicon PECVD photonic integrated devices are promising candidates for low cost sensing applications. This manuscript reports a simulation analysis about the impact on the overall efficiency caused by the lithography imperfections in the deposition process. The tolerance to the fabrication defects of a photonic sensor based on surface plasmonic resonance is analysed. The simulations are performed with FDTD and BPM algorithms. The device is a plasmonic interferometer composed by an a-Si:H waveguide covered by a thin gold layer. The sensing analysis is performed by equally splitting the input light into two arms, allowing the sensor to be calibrated by its reference arm. Two different 1 × 2 power splitter configurations are presented: a directional coupler and a multimode interference splitter. The waveguide sidewall roughness is considered as the major negative effect caused by deposition imperfections. The simulation results show that plasmonic effects can be excited in the interferometric waveguide structure, allowing a sensing device with enough sensitivity to support the functioning of a bio sensor for high throughput screening. In addition, the good tolerance to the waveguide wall roughness, points out the PECVD deposition technique as reliable method for the overall sensor system to be produced in a low-cost system. The large area deposition of photonics structures, allowed by the PECVD method, can be explored to design a multiplexed system for analysis of multiple biomarkers to further increase the tolerance to fabrication defects.

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