scholarly journals An Electrochemical Immunosensor for Sensitive Detection of the Tumor Marker Carcinoembryonic Antigen (CEA) Based on Three-Dimensional Porous Nanoplatinum/Graphene

Micromachines ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 660 ◽  
Author(s):  
Aihua Jing ◽  
Qiong Xu ◽  
Wenpo Feng ◽  
Gaofeng Liang
Keyword(s):  
Tumor Marker ◽  
Carcinoembryonic Antigen ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Platinum Metal ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Diagnosis Of Cancer ◽  
Wet Chemical ◽  
Secondary Antibodies

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal nanoparticles (3DPt/HGO) composites were prepared by a wet chemical method and modified on an electrode with enhanced conductivity, a large surface area, and good adsorption of immobilizing antibodies (Ab1). Horseradish peroxidase (HRP)-functionalized Au nanoparticles were fabricated to label the secondary antibodies (Ab2). The proposed immunosensor showed a good linear relationship in the range of 0.001–150 ng/mL for CEA and a detection limit of 0.0006 ng/mL. The immunosensor had high sensitivity, good stability and reproducibility, and has great application prospects for the clinical diagnosis of cancer.

Application of three-dimensional flower-like nanomaterials in the fabrication of sandwich-type electrochemical immunosensors

RSC Advances ◽  
2015 ◽  
Vol 5 (107) ◽  
pp. 88160-88165 ◽  
Author(s):  
Yulan Wang ◽  
Yan Li ◽  
Lihua Hu ◽  
Xiang Ren ◽  
Bin Du ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Three Dimensional ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Electrochemical Immunosensors ◽  
Sandwich Type

A novel and ultrasensitive sandwich-type electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA) in this work.

A label-free amperometric immunosensor for the detection of carcinoembryonic antigen based on novel magnetic carbon and gold nanocomposites

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 19961-19969 ◽  
Author(s):  
Faying Li ◽  
Liping Jiang ◽  
Jian Han ◽  
Qing Liu ◽  
Yunhui Dong ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Label Free ◽  
Amperometric Immunosensor ◽  
Magnetic Carbon ◽  
Gold Nanocomposites

In this work, a novel label-free electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA).

Electrochemical Immunosensor for Carcinoembryonic Antigen Detection Based on Mo–Mn3O4/MWCNTs/Chits Nanocomposite Modified ITO Electrode

NANO ◽  
2015 ◽  
Vol 10 (08) ◽  
pp. 1550111 ◽  
Author(s):  
Wen-Ting Li ◽  
Yu Wang ◽  
Fen-Fang Deng ◽  
Li-Li Liu ◽  
Hai-Jun Nan ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Indium Tin Oxide ◽  
Incubation Temperature ◽  
Sol Gel ◽  
High Sensitivity ◽  
Electrochemical Immunosensor ◽  
Ito Electrode ◽  
Potential Applications ◽  
Recognition Systems

A novel electrochemical immunosensor for determination of carcinoembryonic antigen (CEA) in human serum was fabricated by depositing Mo–Mn3O4/MWCNTs/Chits nanocomposite onto an indium-tin oxide (ITO) electrode. Mo-doped Mn3O4 (MMO) was synthesized by sol–gel method and the presence of molybdenum improved its electrochemical properties. The MMO/MWCNTs/Chits nanocomposite could accelerate the electron transfer rate and enlarge the surface area to capture a large number of Carcinoembryonic Antigen (CEA). The factors influencing the performance of the immunosensor were investigated, such as incubation time, incubation temperature and pH. Under optimal conditions, the electrochemical immunosensor could detect CEA in a linear range from 0.1[Formula: see text]ng[Formula: see text][Formula: see text][Formula: see text]mL[Formula: see text] to 125[Formula: see text]ng[Formula: see text][Formula: see text][Formula: see text]mL[Formula: see text] with a detection limit of 4.9[Formula: see text]pg[Formula: see text][Formula: see text][Formula: see text]mL[Formula: see text] ([Formula: see text][Formula: see text]). In addition, it exhibited high sensitivity and acceptable stability on a promising immobilization platform for signal amplification, which could be extended to other labeled recognition systems. This electrochemical immunosensor may provide potential applications for the clinical diagnosis.

A novel electrochemical immunosensor based on CoS2 for early screening of tumor marker carcinoembryonic antigen

2020 ◽  
Vol 44 (8) ◽  
pp. 3524-3532 ◽  
Author(s):  
Chulei Zhao ◽  
Chaoyun Ma ◽  
Mei Wu ◽  
Wenjun Li ◽  
Yiju Song ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Carcinoembryonic Antigen ◽  
Signal Amplification ◽  
Electrochemical Immunosensor ◽  
Biometric Recognition ◽  
Early Screening

In this work, PANI–HRP nanoparticles integrate biometric recognition and signal amplification functions in one body, which can be converted to each other without consuming the material itself.

Determination of carcinoembryonic antigen as a tumor marker using a novel graphene-based label-free electrochemical immunosensor

2021 ◽  
Vol 613 ◽  
pp. 114017
Author(s):  
Maryam Jozghorbani ◽  
Mojtaba Fathi ◽  
Sayed Habib Kazemi ◽  
Navid Alinejadian
Keyword(s):  
Tumor Marker ◽  
Carcinoembryonic Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free

Efficient chemosensors for toxic pollutants based on photoluminescent Zn(II) and Cd(II) metal-organic networks

2021 ◽  
Author(s):  
Luis David Rosales-Vazquez ◽  
Alejandro Dorazco-González ◽  
Victor Sanchez-Mendieta
Keyword(s):  
Optical Sensors ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Environmental Research ◽  
Toxic Pollutants ◽  
Sensitivity And Selectivity ◽  
Metal Organic ◽  
Analytical Tools ◽  
Organic Networks

Optical sensors with high sensitivity and selectivity, as important analytical tools for chemical and environmental research, can be accomplished by straightforward synthesis of luminescent one-, two- and three-dimensional Zn(II) and...

Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay

2021 ◽  
Vol 13 (15) ◽  
pp. 1823-1831
Author(s):  
Xiaomei Wang ◽  
Li Ma ◽  
Shijiao Sun ◽  
Tingwei Liu ◽  
Hao Zhou ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
High Sensitivity ◽  
Quantitative Detection ◽  
Detection Time ◽  
Highly Sensitive ◽  
Sandwich Method

We have developed a SERS magnetic immunoassay method based on the principle of sandwich method for rapid and quantitative detection of IL-6. The developed SERS method has the advantages of high sensitivity and detection time is only 15 min.

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