Application of three-dimensional flower-like nanomaterials in the fabrication of sandwich-type electrochemical immunosensors

RSC Advances ◽  
2015 ◽  
Vol 5 (107) ◽  
pp. 88160-88165 ◽  
Author(s):  
Yulan Wang ◽  
Yan Li ◽  
Lihua Hu ◽  
Xiang Ren ◽  
Bin Du ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Three Dimensional ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Electrochemical Immunosensors ◽  
Sandwich Type

A novel and ultrasensitive sandwich-type electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA) in this work.

scholarly journals An Electrochemical Immunosensor for Sensitive Detection of the Tumor Marker Carcinoembryonic Antigen (CEA) Based on Three-Dimensional Porous Nanoplatinum/Graphene

Micromachines ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 660 ◽  
Author(s):  
Aihua Jing ◽  
Qiong Xu ◽  
Wenpo Feng ◽  
Gaofeng Liang
Keyword(s):  
Tumor Marker ◽  
Carcinoembryonic Antigen ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Platinum Metal ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Diagnosis Of Cancer ◽  
Wet Chemical ◽  
Secondary Antibodies

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal nanoparticles (3DPt/HGO) composites were prepared by a wet chemical method and modified on an electrode with enhanced conductivity, a large surface area, and good adsorption of immobilizing antibodies (Ab1). Horseradish peroxidase (HRP)-functionalized Au nanoparticles were fabricated to label the secondary antibodies (Ab2). The proposed immunosensor showed a good linear relationship in the range of 0.001–150 ng/mL for CEA and a detection limit of 0.0006 ng/mL. The immunosensor had high sensitivity, good stability and reproducibility, and has great application prospects for the clinical diagnosis of cancer.

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

scholarly journals Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1745 ◽  
Author(s):  
Alfredo Sánchez ◽  
Anabel Villalonga ◽  
Gonzalo Martínez-García ◽  
Concepción Parrado ◽  
Reynaldo Villalonga
Keyword(s):  
Pharmaceutical Analysis ◽  
State Of The Art ◽  
Three Dimensional ◽  
Electrochemical Immunosensor ◽  
High Impact ◽  
Branched Polymers ◽  
Electrochemical Immunosensors ◽  
Signal Production ◽  
Poly Propylene ◽  
Affinity Biosensors

Electrochemical immunosensors are antibody-based affinity biosensors with a high impact on clinical, environmental, food, and pharmaceutical analysis. In general, the analytical performance of these devices is critically determined by the materials and reagents used for their construction, signal production and amplification. Dendrimers are monodisperse and highly branched polymers with three-dimensional structures widely employed as “soft” nanomaterials in electrochemical immunosensor technology. This review provides an overview on the state-of-the-art in dendrimer-based electrochemical immunosensors, focusing on those using polyamidoamine and poly (propylene imine) dendrimers. Special emphasis is given to the most original methods recently reported for the construction of immunosensor architectures incorporating dendrimers, as well as to novel sensing approaches based on dendrimer-assisted signal enhancement strategies.

Quantitative detection of procalcitonin using an electrochemical immunosensor based on MoO3/Au@rGO nanocomposites

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 6968-6974 ◽  
Author(s):  
Jianqiao Liu ◽  
Li Quan ◽  
Xuelian Yu ◽  
Lin Wang
Keyword(s):  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Layer By Layer ◽  
Sandwich Type

In this work, a sandwich-type electrochemical immunosensor for the detection of procalcitonin (PCT) is constructed layer-by-layer with a novel label based on MoO3/Au@rGO nanocomposites.

A three-dimensional CoNi-MOF nanosheet array-based immunosensor for sensitive monitoring of human chorionic gonadotropin with core–shell ZnNi-MOF@Nile Blue nanotags

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 8097-8103
Author(s):  
Wenbo Lu ◽  
Zi-Ang Chen ◽  
Ming Wei ◽  
Xiaowei Cao ◽  
Xuping Sun
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Nile Blue ◽  
Three Dimensional ◽  
Electrochemical Immunosensor ◽  
Core Shell ◽  
Nanosheet Array ◽  
Sandwich Type

A sandwich-type electrochemical immunosensor for HCG detection based on a CoNi-MOF nanosheet-array and Nile Blue@ZnNi-MOF spheres is successfully exploited.

Sandwich-type electrochemical immunosensor for carcinoembryonic antigen detection based on the cooperation of a gold–vertical graphene electrode and gold@silica–methylene blue

2020 ◽  
Vol 8 (2) ◽  
pp. 298-307 ◽  
Author(s):  
Siyu Zheng ◽  
Mingji Li ◽  
Hongji Li ◽  
Cuiping Li ◽  
Penghai Li ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Carcinoembryonic Antigen ◽  
Electrochemical Immunosensor ◽  
Antigen Detection ◽  
Graphene Electrode ◽  
Sandwich Type

In this study, a sandwich-type electrochemical (EC) immunosensor was proposed to detect a carcinoembryonic antigen (CEA) based on Au–graphene and Au@SiO2–methylene blue (MB).

A label-free amperometric immunosensor for the detection of carcinoembryonic antigen based on novel magnetic carbon and gold nanocomposites

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 19961-19969 ◽  
Author(s):  
Faying Li ◽  
Liping Jiang ◽  
Jian Han ◽  
Qing Liu ◽  
Yunhui Dong ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Electrochemical Immunosensor ◽  
Quantitative Detection ◽  
Label Free ◽  
Amperometric Immunosensor ◽  
Magnetic Carbon ◽  
Gold Nanocomposites

In this work, a novel label-free electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA).

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