scholarly journals In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae

Materials ◽  
2011 ◽  
Vol 4 (12) ◽  
pp. 2197-2218 ◽  
Author(s):  
Berit Ullmann ◽  
Janin Reifenrath ◽  
Dina Dziuba ◽  
Jan-Marten Seitz ◽  
Dirk Bormann ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Degradation Behavior ◽  
In Vivo Degradation

scholarly journals In-Vivo Degradation Behavior and Osseointegration of 3D Powder-Printed Calcium Magnesium Phosphate Cement Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 946
Author(s):  
Katharina Kowalewicz ◽  
Elke Vorndran ◽  
Franziska Feichtner ◽  
Anja-Christina Waselau ◽  
Manuel Brueckner ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bone Substitutes ◽  
Magnesium Phosphate ◽  
Degradation Behavior ◽  
Micro Computed Tomography ◽  
Calcium Magnesium ◽  
Interest In Research ◽  
In Vivo Degradation ◽  
Volume Decrease

Calcium magnesium phosphate cements (CMPCs) are promising bone substitutes and experience great interest in research. Therefore, in-vivo degradation behavior, osseointegration and biocompatibility of three-dimensional (3D) powder-printed CMPC scaffolds were investigated in the present study. The materials Mg225 (Ca0.75Mg2.25(PO4)2) and Mg225d (Mg225 treated with diammonium hydrogen phosphate (DAHP)) were implanted as cylindrical scaffolds (h = 5 mm, Ø = 3.8 mm) in both lateral femoral condyles in rabbits and compared with tricalcium phosphate (TCP). Treatment with DAHP results in the precipitation of struvite, thus reducing pore size and overall porosity and increasing pressure stability. Over 6 weeks, the scaffolds were evaluated clinically, radiologically, with Micro-Computed Tomography (µCT) and histological examinations. All scaffolds showed excellent biocompatibility. X-ray and in-vivo µCT examinations showed a volume decrease and increasing osseointegration over time. Structure loss and volume decrease were most evident in Mg225. Histologically, all scaffolds degraded centripetally and were completely traversed by new bone, in which the remaining scaffold material was embedded. While after 6 weeks, Mg225d and TCP were still visible as a network, only individual particles of Mg225 were present. Based on these results, Mg225 and Mg225d appear to be promising bone substitutes for various loading situations that should be investigated further.

In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg–Zn–Ca alloy for bone implant application

2011 ◽  
Vol 88 (1) ◽  
pp. 254-259 ◽  
Author(s):  
Huanxin Wang ◽  
Shaokang Guan ◽  
Yisheng Wang ◽  
Hongjian Liu ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Bone Implant ◽  
In Vivo Degradation

Comparison of the In Vivo Degradation Progress of Solid Magnesium Alloy Cylinders and Screw-Shaped Magnesium Alloy Cylinders in a Rabbit Model

2010 ◽  
Vol 638-642 ◽  
pp. 742-747 ◽  
Author(s):  
Nina von der Höh ◽  
Dirk Bormann ◽  
Arne Lucas ◽  
Fritz Thorey ◽  
Andrea Meyer-Lindenberg
Keyword(s):  
Magnesium Alloy ◽  
Pitting Corrosion ◽  
Femoral Condyle ◽  
Rabbit Model ◽  
Degradation Behavior ◽  
Gas Generation ◽  
Cross Sectional ◽  
Bone Implant ◽  
Computed Tomograph

Resorbable magnesium alloy implants for osteosynthetic surgery would be advantageous to common implants of titanium or surgical steel as a second surgery for implant removal would become unnecessary. To influence the degradation progress, surface modifications are sensible. As plates and screws were used to stabilize fractures, the degradation behavior of threaded cylinders is of particular interest. Therefore each eight solid MgCa0.8 alloy cylinders (3 x 5 mm) with smooth and sandblasted surface, respectively, and eight screw-shaped, threaded MgCa0.8 cylinders (thread pitch 1.25 mm, length 5 mm) were inserted into the medial femoral condyle of adult New Zealand White rabbits. Implantation periods were three and six months, within which the animals were examined daily. To evaluate a possible gas generation radiographs were taken weekly. After euthanasia the bone-implant-compound was scanned in a µ-computed tomograph (µCT80, ScancoMedical). All implants were well tolerated. Smooth implants degraded slowly. The cross sectional area did not reduce obviously after three months implantation duration and only mildly after six months. Sandblasted implants showed the fastest degradation progress after both implantation periods with the most obvious generation of gas. Threaded cylinders revealed pitting corrosion at the thread pitches. They degrade faster than smooth implants but slower than sandblasted cylinders. In summary, surface modification influences the degradation behavior of resorbable magnesium alloy implants. Contrary to common materials, smooth surfaces seem to be favorable. Thread pitches of screw-shaped implants show pitting corrosion. To what extend this result affects future applications of resorbable screws has to be examined in further investigations.

In Vivo Degradation Behavior of Photo-Cross-Linkedstar-Poly(ε-caprolactone-co-d,l-lactide) Elastomers

2006 ◽  
Vol 7 (1) ◽  
pp. 365-372 ◽  
Author(s):  
Brian G. Amsden ◽  
M. Yat Tse ◽  
Norma D. Turner ◽  
Darryl K. Knight ◽  
Stephen C. Pang
Keyword(s):  
Degradation Behavior ◽  
In Vivo Degradation

Comparison between three in vitro methods to measure magnesium degradation and their suitability for predicting in vivo degradation

2018 ◽  
Vol 41 (11) ◽  
pp. 772-778 ◽  
Author(s):  
Sara R Knigge ◽  
Birgit Glasmacher
Keyword(s):  
Continuous Flow ◽  
Initial Phase ◽  
Ph Value ◽  
Degradation Products ◽  
Static Condition ◽  
Degradation Behavior ◽  
Implant Material ◽  
Static Conditions ◽  
In Vivo Degradation

A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation. Two commonly used experimental protocols were examined: static conditions and a fluid changing method. For static testing, the samples stayed in fluid. For the fluid changing method, the fluid was changed after 2 and 5 days of immersion. In addition, a new method with continuous fluid flow was established. After an initial phase, the results confirm that for all three methods, the degradation behavior differs strongly. The static condition results in a very slow degradation rate. The fluid change method leads to a similar behavior like the static condition except that the degradation was speeded up after the fluid changes. The continuous degradation is linear for a long period after the initial phase. In comparison with in vivo degradation behavior, the degradation process in continuous flow shows the best fitting. The accumulation of degradation products, especially the increasing pH value, has a strong inhibiting effect. This cannot be observed in vivo so that a constant experimental environment realizable by continuous flow is more suitable for magnesium-based implant material testing.

scholarly journals Osteogenesis and degradation behavior of magnesium alloy plate in vivo

2021 ◽  
Vol 19 ◽  
pp. 205873922110340
Author(s):  
Yongping Wang ◽  
Wenqiang Liang ◽  
Xiaorong Liu ◽  
Qiangqiang Li ◽  
Yadong Xie ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Magnesium Alloy ◽  
Control Group ◽  
Degradation Behavior ◽  
Alloy Plate ◽  
Plate Group ◽  
Titanium Alloy Plate ◽  
And Control ◽  
Experimental Group

Introduction: The magnesium alloy was fabricated into orthopedic plates, and used to repair tibial fractures of New Zealand white rabbits. The osteogenesis and degradation behavior of magnesium alloy plates were investigated in vivo. Methods: 38 rabbits were randomly divided into an experimental group using the magnesium alloy plate and control group using a titanium alloy plate. Tibial fractures in the experimental group and control group were fixed with magnesium alloy plates and titanium alloy plates, respectively. An X-ray of the fracture site was taken at 1, 2, 4, 8, and 16 weeks after surgery. The formation of callus and expression of bone morphogenetic protein (BMP-2) in each group were examined at 4, 8, and 16 weeks postoperatively. The degradation behavior of the magnesium alloy plate was observed using a scanning electron microscope with an energy dispersive spectroscopy system. Results: The results of X-ray showed that the fracture healed gradually and there was significant callus around the plate in the magnesium alloy plate group than that in the titanium alloy plate groups. The formation of callus and the expression of BMP-2 in the magnesium alloy plate group were more significant than that in the titanium plate group. The degradation behavior of the magnesium alloy plates deepened in vivo with the implantation time. Conclusion: The results demonstrated that the magnesium alloy plate implanted into the rabbit tibia could promote the formation of callus and result in osteogenesis in vivo. Meanwhile, the magnesium alloy plate was absorbed gradually in vivo.

On the In Vivo Degradation Performance of Stranded 125I Seeds Connected With AZ31B Magnesium Alloy

Brachytherapy ◽  
2011 ◽  
Vol 10 ◽  
pp. S98 ◽  
Author(s):  
Fu-jun Zhang ◽  
Chuan-xing Li ◽  
Guang-feng Duan ◽  
Dong Chen ◽  
Jian-jun Han
Keyword(s):  
Magnesium Alloy ◽  
Az31b Magnesium Alloy ◽  
125I Seeds ◽  
In Vivo Degradation

In vivo degradation behavior of PDC multiblock copolymers containing poly(para-dioxanone) hard segments and crystallizable poly(epsilon-caprolactone) switching segments

2009 ◽  
Vol 1190 ◽  
Author(s):  
Bernhard Hiebl ◽  
Karl Kratz ◽  
Rosemarie Fuhrmann ◽  
Friedrich Jung ◽  
Andres Lendlein ◽  
...  
Keyword(s):  
Enzymatic Degradation ◽  
Degradation Products ◽  
In Vivo Studies ◽  
Multiblock Copolymers ◽  
Degradation Behavior ◽  
Hard Segments ◽  
In Vivo Degradation ◽  
Good Agreement

AbstractThe degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(epsilon-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(epsilon-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1 – 3 micron.

In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model

2013 ◽  
Vol 58 (5) ◽  
Author(s):  
Tobias Schilling ◽  
Gudrun Brandes ◽  
Igor Tudorache ◽  
Serghei Cebotari ◽  
Andres Hilfiker ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Swine Model ◽  
Temporary Stabilization ◽  
In Vivo Degradation
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