In Vivo Degradation Behavior of Photo-Cross-Linkedstar-Poly(ε-caprolactone-co-d,l-lactide) Elastomers

2006 ◽  
Vol 7 (1) ◽  
pp. 365-372 ◽  
Author(s):  
Brian G. Amsden ◽  
M. Yat Tse ◽  
Norma D. Turner ◽  
Darryl K. Knight ◽  
Stephen C. Pang
Keyword(s):  
Degradation Behavior ◽  
In Vivo Degradation

scholarly journals In-Vivo Degradation Behavior and Osseointegration of 3D Powder-Printed Calcium Magnesium Phosphate Cement Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 946
Author(s):  
Katharina Kowalewicz ◽  
Elke Vorndran ◽  
Franziska Feichtner ◽  
Anja-Christina Waselau ◽  
Manuel Brueckner ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bone Substitutes ◽  
Magnesium Phosphate ◽  
Degradation Behavior ◽  
Micro Computed Tomography ◽  
Calcium Magnesium ◽  
Interest In Research ◽  
In Vivo Degradation ◽  
Volume Decrease

Calcium magnesium phosphate cements (CMPCs) are promising bone substitutes and experience great interest in research. Therefore, in-vivo degradation behavior, osseointegration and biocompatibility of three-dimensional (3D) powder-printed CMPC scaffolds were investigated in the present study. The materials Mg225 (Ca0.75Mg2.25(PO4)2) and Mg225d (Mg225 treated with diammonium hydrogen phosphate (DAHP)) were implanted as cylindrical scaffolds (h = 5 mm, Ø = 3.8 mm) in both lateral femoral condyles in rabbits and compared with tricalcium phosphate (TCP). Treatment with DAHP results in the precipitation of struvite, thus reducing pore size and overall porosity and increasing pressure stability. Over 6 weeks, the scaffolds were evaluated clinically, radiologically, with Micro-Computed Tomography (µCT) and histological examinations. All scaffolds showed excellent biocompatibility. X-ray and in-vivo µCT examinations showed a volume decrease and increasing osseointegration over time. Structure loss and volume decrease were most evident in Mg225. Histologically, all scaffolds degraded centripetally and were completely traversed by new bone, in which the remaining scaffold material was embedded. While after 6 weeks, Mg225d and TCP were still visible as a network, only individual particles of Mg225 were present. Based on these results, Mg225 and Mg225d appear to be promising bone substitutes for various loading situations that should be investigated further.

In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg–Zn–Ca alloy for bone implant application

2011 ◽  
Vol 88 (1) ◽  
pp. 254-259 ◽  
Author(s):  
Huanxin Wang ◽  
Shaokang Guan ◽  
Yisheng Wang ◽  
Hongjian Liu ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Bone Implant ◽  
In Vivo Degradation

Comparison between three in vitro methods to measure magnesium degradation and their suitability for predicting in vivo degradation

2018 ◽  
Vol 41 (11) ◽  
pp. 772-778 ◽  
Author(s):  
Sara R Knigge ◽  
Birgit Glasmacher
Keyword(s):  
Continuous Flow ◽  
Initial Phase ◽  
Ph Value ◽  
Degradation Products ◽  
Static Condition ◽  
Degradation Behavior ◽  
Implant Material ◽  
Static Conditions ◽  
In Vivo Degradation

A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation. Two commonly used experimental protocols were examined: static conditions and a fluid changing method. For static testing, the samples stayed in fluid. For the fluid changing method, the fluid was changed after 2 and 5 days of immersion. In addition, a new method with continuous fluid flow was established. After an initial phase, the results confirm that for all three methods, the degradation behavior differs strongly. The static condition results in a very slow degradation rate. The fluid change method leads to a similar behavior like the static condition except that the degradation was speeded up after the fluid changes. The continuous degradation is linear for a long period after the initial phase. In comparison with in vivo degradation behavior, the degradation process in continuous flow shows the best fitting. The accumulation of degradation products, especially the increasing pH value, has a strong inhibiting effect. This cannot be observed in vivo so that a constant experimental environment realizable by continuous flow is more suitable for magnesium-based implant material testing.

In vivo degradation behavior of PDC multiblock copolymers containing poly(para-dioxanone) hard segments and crystallizable poly(epsilon-caprolactone) switching segments

2009 ◽  
Vol 1190 ◽  
Author(s):  
Bernhard Hiebl ◽  
Karl Kratz ◽  
Rosemarie Fuhrmann ◽  
Friedrich Jung ◽  
Andres Lendlein ◽  
...  
Keyword(s):  
Enzymatic Degradation ◽  
Degradation Products ◽  
In Vivo Studies ◽  
Multiblock Copolymers ◽  
Degradation Behavior ◽  
Hard Segments ◽  
In Vivo Degradation ◽  
Good Agreement

AbstractThe degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(epsilon-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(epsilon-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1 – 3 micron.

scholarly journals In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae

Materials ◽  
2011 ◽  
Vol 4 (12) ◽  
pp. 2197-2218 ◽  
Author(s):  
Berit Ullmann ◽  
Janin Reifenrath ◽  
Dina Dziuba ◽  
Jan-Marten Seitz ◽  
Dirk Bormann ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Degradation Behavior ◽  
In Vivo Degradation

Does artificial aging correctly predict the long-term in-vivo degradation behavior in zirconia hip prostheses?

2020 ◽  
Vol 31 (2) ◽  
pp. 107-117
Author(s):  
Toshiyuki Tateiwa ◽  
Yasuhito Takahashi ◽  
Giuseppe Pezzotti ◽  
Takaaki Shishido ◽  
Toshinori Masaoka ◽  
...  
Keyword(s):  
Artificial Aging ◽  
Degradation Behavior ◽  
Hip Prostheses ◽  
In Vivo Degradation

scholarly journals In vitro and in vivo degradation behavior of Mg–2Sr–Ca and Mg–2Sr–Zn alloys

2020 ◽  
Vol 5 (2) ◽  
pp. 275-285 ◽  
Author(s):  
Kai Chen ◽  
Xinhui Xie ◽  
Hongyan Tang ◽  
Hui Sun ◽  
Ling Qin ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
In Vivo Degradation ◽  
Zn Alloys
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