In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model

Author(s):  
Tobias Schilling ◽  
Gudrun Brandes ◽  
Igor Tudorache ◽  
Serghei Cebotari ◽  
Andres Hilfiker ◽  
...  
Brachytherapy ◽  
2011 ◽  
Vol 10 ◽  
pp. S98 ◽  
Author(s):  
Fu-jun Zhang ◽  
Chuan-xing Li ◽  
Guang-feng Duan ◽  
Dong Chen ◽  
Jian-jun Han

Materials ◽  
2011 ◽  
Vol 4 (12) ◽  
pp. 2197-2218 ◽  
Author(s):  
Berit Ullmann ◽  
Janin Reifenrath ◽  
Dina Dziuba ◽  
Jan-Marten Seitz ◽  
Dirk Bormann ◽  
...  

2013 ◽  
Vol 33 (7) ◽  
pp. 3881-3888 ◽  
Author(s):  
Xiao Lin ◽  
Lili Tan ◽  
Qiang Wang ◽  
Guangdao Zhang ◽  
Bingchun Zhang ◽  
...  

Author(s):  
Berit Ullmann ◽  
Janin Reifenrath ◽  
Jan-Marten Seitz ◽  
Dirk Bormann ◽  
Andrea Meyer-Lindenberg

2013 ◽  
Vol 9 (10) ◽  
pp. 8548-8560 ◽  
Author(s):  
Dina Dziuba ◽  
Andrea Meyer-Lindenberg ◽  
Jan Marten Seitz ◽  
Hazibullah Waizy ◽  
Nina Angrisani ◽  
...  

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.


Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 946
Author(s):  
Katharina Kowalewicz ◽  
Elke Vorndran ◽  
Franziska Feichtner ◽  
Anja-Christina Waselau ◽  
Manuel Brueckner ◽  
...  

Calcium magnesium phosphate cements (CMPCs) are promising bone substitutes and experience great interest in research. Therefore, in-vivo degradation behavior, osseointegration and biocompatibility of three-dimensional (3D) powder-printed CMPC scaffolds were investigated in the present study. The materials Mg225 (Ca0.75Mg2.25(PO4)2) and Mg225d (Mg225 treated with diammonium hydrogen phosphate (DAHP)) were implanted as cylindrical scaffolds (h = 5 mm, Ø = 3.8 mm) in both lateral femoral condyles in rabbits and compared with tricalcium phosphate (TCP). Treatment with DAHP results in the precipitation of struvite, thus reducing pore size and overall porosity and increasing pressure stability. Over 6 weeks, the scaffolds were evaluated clinically, radiologically, with Micro-Computed Tomography (µCT) and histological examinations. All scaffolds showed excellent biocompatibility. X-ray and in-vivo µCT examinations showed a volume decrease and increasing osseointegration over time. Structure loss and volume decrease were most evident in Mg225. Histologically, all scaffolds degraded centripetally and were completely traversed by new bone, in which the remaining scaffold material was embedded. While after 6 weeks, Mg225d and TCP were still visible as a network, only individual particles of Mg225 were present. Based on these results, Mg225 and Mg225d appear to be promising bone substitutes for various loading situations that should be investigated further.


2021 ◽  
Vol 27 ◽  
pp. 102369
Author(s):  
Shijun Lu ◽  
Xiaochen Tang ◽  
Qingqing Lu ◽  
Jiwei Huang ◽  
Xinran You ◽  
...  

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