scholarly journals Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

2020 ◽  
Vol 21 (18) ◽  
pp. 6621
Author(s):  
Filippo Pinelli ◽  
Fabio Pizzetti ◽  
Óscar Fullana Ortolà ◽  
Alessandro Marchetti ◽  
Arianna Rossetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
High Volume ◽  
Polymer Chains ◽  
Pluronic F127 ◽  
Synthesis Methods ◽  
Drug Delivery Vehicles ◽  
The Core ◽  
Delivery Vehicles ◽  
Novel Drug

In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Carbon Nanotubes as Drug Delivery Vehicles

2014 ◽  
Vol 222 ◽  
pp. 145-158 ◽  
Author(s):  
Shweta Arora ◽  
Vanish Kumar ◽  
Shriniwas Yadav ◽  
Sukhbir Singh ◽  
Deepika Bhatnagar ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Building Blocks ◽  
Water Soluble ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Toxicological Profile ◽  
Drug Doses ◽  
Delivery Vehicles ◽  
Novel Drug

Various biomedical applications of nanomaterials have been proposed in the last few years leading to the emergence of a new field in diagnostics and therapeutics. Most of these applications involve the administration of nanoparticles into patients. Carbon Nanotubes are enjoying increasing popularity as building blocks for novel drug delivery systems as well as for bioimaging and biosensing. The recent strategies to functionalize carbon nanotubes have resulted in the generation of biocompatible and water-soluble carbon nanotubes that are well suited for high treatment efficacy and minimum side effects for future cancer therapies with low drug doses. The toxicological profile of such carbon nanotube systems developed as nanomedicines will have to be determined prior to any clinical studies undertaken.

scholarly journals Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Xue Shen ◽  
Xiyang Liu ◽  
Tingting Li ◽  
Yin Chen ◽  
Yang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Cancer Diagnosis ◽  
Drug Loading ◽  
Essential Information ◽  
Drug Delivery Vehicles ◽  
Albumin Nanoparticles ◽  
Diagnosis And Therapy ◽  
Delivery Vehicles ◽  
Cancer Diagnosis And Therapy

Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution. Among the various organic or inorganic materials that used to prepare drug delivery vehicles for effective cancer treatment, serum albumin-based nanovehicles have been widely developed and investigated due to their prominent superiorities, including good biocompatibility, high stability, nontoxicity, non-immunogenicity, easy preparation, and functionalization, allowing them to be promising candidates for cancer diagnosis and therapy. This article reviews the recent advances on the applications of serum albumin-based nanovehicles in cancer diagnosis and therapy. We first introduce the essential information of bovine serum albumin (BSA) and human serum albumin (HSA), and discuss their drug loading strategies. We then discuss the different types of serum albumin-based nanovehicles including albumin nanoparticles, surface-functionalized albumin nanoparticles, and albumin nanocomplexes. Moreover, after briefly discussing the application of serum albumin-based nanovehicles used as the nanoprobes in cancer diagnosis, we also describe the serum albumin-based nanovehicle-assisted cancer theranostics, involving gas therapy, chemodynamic therapy (CDT), phototherapy (PTT/PDT), sonodynamic therapy (SDT), and other therapies as well as cancer imaging. Numerous studies cited in our review show that serum albumin-based nanovehicles possess a great potential in cancer diagnostic and therapeutic applications.

scholarly journals Utilization of Nanomaterials in Target Oriented Drug Delivery Vehicles

2021 ◽  
Vol 13 (1) ◽  
pp. 299-316
Author(s):  
T. K. Mandal ◽  
V. Patait
Keyword(s):  
Drug Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Current Status ◽  
Future Perspectives ◽  
Delivery Vehicle ◽  
Treatment Target ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Novel Drug ◽  
Cancerous Cells

The present investigation deals with the fundamentals of nanorobots, its fabrication, and possible utilization in a different target-oriented drug delivery vehicles. Details of various types of nanorobots and their specific applications are studied in this research. The use of nanorobots in cancer treatment, target-oriented drug delivery, medical imaging, and in new health sensing devices has also been studied. The mechanism of action of nanorobots for the treatment of cancerous cells as well as the formulation and working functions of some recently studied nanorobots are investigated in this work. This paper reviews the research in finding the suitable nanorobotic materials, different fabrication processes of nanorobots, and the current status of application of nanorobots in biomedical, especially in the treatment of cancers. Superparamagnetic iron oxide nanoparticles (SPIONs) have been observed to be used as novel drug delivery vehicle materials. The future perspectives of nanorobots for the utilization in drug delivery are also addressed herewith.

scholarly journals The state-of-play and future of platinum drugs

2015 ◽  
Vol 22 (4) ◽  
pp. R219-R233 ◽  
Author(s):  
Michael G Apps ◽  
Eugene H Y Choi ◽  
Nial J Wheate
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
50Th Anniversary ◽  
Platinum Drugs ◽  
Research Focus ◽  
Preclinical Development ◽  
Drug Delivery Vehicles ◽  
Enhanced Permeability And Retention ◽  
Delivery Vehicles ◽  
Proteins And Peptides

The year 2015 marks the 50th anniversary since the discovery of the anticancer potential of cisplatin and it remains just as useful now as it did back then, especially for the treatment of some endocrine-related cancers like ovarian and testicular carcinomas. Since its discovery, five other platin drugs have received approval in various countries. While several new platin drugs are in preclinical development, in the last decade only two new platin drugs have entered clinical trials, LA-12 and dicycloplatin, reflecting a shift in research focus from new drug design to improved formulations of already approved platin drugs. These formulations include their encapsulation with macrocycles to slow and prevent their degradation by proteins and peptides; their attachment to nanoparticles to passively target solid tumours through the enhanced permeability and retention effect and their coordination to important nutrients, proteins, antibodies and aptamers for active tumour targeting. These formulation methods have all shown potential but none have yet yielded a new marketable medicine containing a platin drug. The reasons for this are problems of consistent drug loading, controlling the location and timing of drug release and the inherent toxicity of some of the drug delivery vehicles. In addition to drug delivery, functional genomics is now playing an increasing role in predicting patients' responses to platin chemotherapy and their likelihood of experiencing severe side effects.

Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

2016 ◽  
Vol 69 (2) ◽  
pp. 204 ◽  
Author(s):  
Soheila Kashanian ◽  
Elham Rostami ◽  
Frances J. Harding ◽  
Steven J. P. McInnes ◽  
Sameer Al-Bataineh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Release Kinetics ◽  
Drug Loading ◽  
Controlled Delivery ◽  
Sustained Drug Release ◽  
Drug Delivery Vehicles ◽  
Zero Order Release ◽  
Delivery Vehicles

Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50 % and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.

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