scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

scholarly journals Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 130 ◽  
Author(s):  
Yahui He ◽  
Shaomei Zeng ◽  
A. M. Abd El-Aty ◽  
Ahmet Hacımüftüoğlu ◽  
Woldemariam Kalekristos Yohannes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Isotherm Models ◽  
Template Molecule ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Potential Applications

Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.

Molecularly imprinted polymers for the detection of viruses: challenges and opportunities

The Analyst ◽  
2021 ◽  
Author(s):  
Ghazaleh Jamalipour Soufi ◽  
Siavash Iravani ◽  
Rajender S Varma
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Structure Determination ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Cell Culturing ◽  
Challenges And Opportunities

Molecularly imprinted polymers (MIPs) have numerous applications in sensing field, the detection/recognition of virus, the structure determination of proteins, drug delivery, artificial/biomimetic antibodies, drug discovery, and cell culturing. There are...

pH/temperature-sensitive hydrogel-based molecularly imprinted polymers (hydroMIPs) for drug delivery by frontal polymerization

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 94038-94047 ◽  
Author(s):  
Xiao-Lin Wang ◽  
Hong-Fei Yao ◽  
Xiu-Yuan Li ◽  
Xu Wang ◽  
Yan-Ping Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Frontal Polymerization ◽  
Temperature Sensitive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Temperature Sensitive Hydrogel ◽  
First Time

Frontal polymerization was successfully utilized, for the first time, to obtain pH/temperature-sensitive hydrogel-based molecularly imprinted polymers (hydroMIPs).

scholarly journals Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Xue Shen ◽  
Xiyang Liu ◽  
Tingting Li ◽  
Yin Chen ◽  
Yang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Cancer Diagnosis ◽  
Drug Loading ◽  
Essential Information ◽  
Drug Delivery Vehicles ◽  
Albumin Nanoparticles ◽  
Diagnosis And Therapy ◽  
Delivery Vehicles ◽  
Cancer Diagnosis And Therapy

Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution. Among the various organic or inorganic materials that used to prepare drug delivery vehicles for effective cancer treatment, serum albumin-based nanovehicles have been widely developed and investigated due to their prominent superiorities, including good biocompatibility, high stability, nontoxicity, non-immunogenicity, easy preparation, and functionalization, allowing them to be promising candidates for cancer diagnosis and therapy. This article reviews the recent advances on the applications of serum albumin-based nanovehicles in cancer diagnosis and therapy. We first introduce the essential information of bovine serum albumin (BSA) and human serum albumin (HSA), and discuss their drug loading strategies. We then discuss the different types of serum albumin-based nanovehicles including albumin nanoparticles, surface-functionalized albumin nanoparticles, and albumin nanocomplexes. Moreover, after briefly discussing the application of serum albumin-based nanovehicles used as the nanoprobes in cancer diagnosis, we also describe the serum albumin-based nanovehicle-assisted cancer theranostics, involving gas therapy, chemodynamic therapy (CDT), phototherapy (PTT/PDT), sonodynamic therapy (SDT), and other therapies as well as cancer imaging. Numerous studies cited in our review show that serum albumin-based nanovehicles possess a great potential in cancer diagnostic and therapeutic applications.

scholarly journals Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

Polymers ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 1689-1715 ◽  
Author(s):  
Wei Chen ◽  
Yue Ma ◽  
Jianmin Pan ◽  
Zihui Meng ◽  
Guoqing Pan ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Synthesis of fluorescent drug molecules for competitive binding assay based on molecularly imprinted polymers

RSC Advances ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 6779-6784 ◽  
Author(s):  
Muyasier Wubulikasimu ◽  
Turghun Muhammad ◽  
Mukhtar Imerhasan ◽  
Nurmemet Hudaberdi ◽  
Wenwu Yang ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Assay ◽  
Competitive Binding ◽  
Natural Antibody ◽  
Competitive Binding Assay ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Molecules ◽  
Immunosorbent Assays

Drug molecules (metronidazole, zidovudine and lamivudine) were successfully labelled with a fluorescent reagent and used to develop fluorescent biomimetic immunosorbent assays using molecularly imprinted polymers in the place of natural antibody.

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