scholarly journals Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

2015 ◽  
Vol 17 (1) ◽  
pp. 16 ◽  
Author(s):  
Sabita Saldanha ◽  
Kendra Royston ◽  
Neha Udayakumar ◽  
Trygve Tollefsbol
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Epigenetic Regulation ◽  
Epidermal Stem Cell

CD271 promotes STZ-induced diabetic wound healing and regulates epidermal stem cell survival in the presence of the pTrkA receptor

2019 ◽  
Vol 379 (1) ◽  
pp. 181-193
Author(s):  
Min Zhang ◽  
Rui Zhang ◽  
Xiaohong Li ◽  
Yongqian Cao ◽  
Kaifeng Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Survival ◽  
Diabetic Wound ◽  
Epidermal Stem Cell ◽  
Stem Cell Survival ◽  
Diabetic Wound Healing

scholarly journals Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation

2021 ◽  
Vol 22 (15) ◽  
pp. 7813
Author(s):  
Lindsay Kraus ◽  
Chris Bryan ◽  
Marcus Wagner ◽  
Tabito Kino ◽  
Melissa Gunchenko ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dna Damage ◽  
Stem Cell ◽  
Histone Modification ◽  
Epigenetic Regulation ◽  
Critical Role ◽  
Proliferative Potential ◽  
Therapeutic Effects ◽  
Histone 3

Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and mortality worldwide. Multiple stem cell types have been safely transferred into failing human hearts, but the overall clinical cardiovascular benefits have been modest. Therefore, there is a dire need to understand the basic biology of stem cells to enhance therapeutic effects. Bmi1 is part of the polycomb repressive complex 1 (PRC1) that is involved in different processes including proliferation, survival and differentiation of stem cells. We isolated cortical bones stem cells (CBSCs) from bone stroma, and they express significantly high levels of Bmi1 compared to mesenchymal stem cells (MSCs) and cardiac-derived stem cells (CDCs). Using lentiviral transduction, Bmi1 was knocked down in the CBSCs to determine the effect of loss of Bmi1 on proliferation and survival potential with or without Bmi1 in CBSCs. Our data show that with the loss of Bmi1, there is a decrease in CBSC ability to proliferate and survive during stress. This loss of functionality is attributed to changes in histone modification, specifically histone 3 lysine 27 (H3K27). Without the proper epigenetic regulation, due to the loss of the polycomb protein in CBSCs, there is a significant decrease in cell cycle proteins, including Cyclin B, E2F, and WEE as well as an increase in DNA damage genes, including ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR). In conclusion, in the absence of Bmi1, CBSCs lose their proliferative potential, have increased DNA damage and apoptosis, and more cell cycle arrest due to changes in epigenetic modifications. Consequently, Bmi1 plays a critical role in stem cell proliferation and survival through cell cycle regulation, specifically in the CBSCs. This regulation is associated with the histone modification and regulation of Bmi1, therefore indicating a novel mechanism of Bmi1 and the epigenetic regulation of stem cells.

scholarly journals Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. VOLUME 283 (2008) PAGES 27644-27652

2009 ◽  
Vol 284 (13) ◽  
pp. 8995
Author(s):  
Xuekun Li ◽  
Basam Z. Barkho ◽  
Jinfeng Bao ◽  
Yuping Luo ◽  
Richard D. Smrt ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Epigenetic Regulation ◽  
Neural Stem Progenitor Cells ◽  
Cell Mitogen

scholarly journals Epigenetic regulation of cellular functions in wound healing

2021 ◽  
Author(s):  
Irena Pastar ◽  
Jelena Marjanovic ◽  
Rivka C. Stone ◽  
Vivien Chen ◽  
Jamie L. Burgess ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epigenetic Regulation ◽  
Cellular Functions
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