scholarly journals Risk-Association of CYP11A1 Polymorphisms and Breast Cancer Among Han Chinese Women in Southern China

2012 ◽  
Vol 13 (4) ◽  
pp. 4896-4905 ◽  
Author(s):  
Minying Sun ◽  
Xuexi Yang ◽  
Changsheng Ye ◽  
Weiwen Xu ◽  
Guangyu Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Southern China ◽  
Han Chinese ◽  
Risk Association

scholarly journals Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kai Wang ◽  
Guanying Wang ◽  
Shangke Huang ◽  
Anqi Luo ◽  
Xin Jing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Chinese Women ◽  
Han Chinese

scholarly journals Risk-Association of Five SNPs in TOX3/LOC643714 with Breast Cancer in Southern China

2014 ◽  
Vol 15 (2) ◽  
pp. 2130-2141 ◽  
Author(s):  
Xuanqiu He ◽  
Guangyu Yao ◽  
Fenxia Li ◽  
Ming Li ◽  
Xuexi Yang
Keyword(s):  
Breast Cancer ◽  
Southern China ◽  
Risk Association

A Cross-Sectional Study of Associations Between Nonsynonymous Mutations of the BARD1 Gene and Breast Cancer in Han Chinese Women

2013 ◽  
Vol 25 (4_suppl) ◽  
pp. 8S-14S ◽  
Author(s):  
Hui Liu ◽  
Hengwei Zhang ◽  
Xianfu Sun ◽  
Yaning He ◽  
Juntao Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals A case-control study on risk factors of breast cancer in Han Chinese women

Oncotarget ◽  
2017 ◽  
Vol 8 (57) ◽  
pp. 97217-97230 ◽  
Author(s):  
Li-Yuan Liu ◽  
Fei Wang ◽  
Shu-De Cui ◽  
Fu-Guo Tian ◽  
Zhi-Min Fan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Han Chinese ◽  
Control Study

scholarly journals Heterogeneity of Breast Cancer Associations with Common Genetic Variants inFGFR2according to the Intrinsic Subtypes in Southern Han Chinese Women

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Huiying Liang ◽  
Xuexi Yang ◽  
Lujia Chen ◽  
Hong Li ◽  
Anna Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Chinese Women ◽  
Intrinsic Subtype ◽  
Han Chinese ◽  
Dependent Manner ◽  
Intrinsic Subtypes ◽  
Luminal A ◽  
Luminal B ◽  
Common Genetic Variants

GWAS have identified variation in theFGFR2locus as risk factors for breast cancer. Validation studies, however, have shown inconsistent results by ethnics and pathological characteristics. To further explore this inconsistency and investigate the associations ofFGFR2variants with breast cancer according to intrinsic subtype (Luminal-A, Luminal-B, ER−&PR−&HER2+, and triple negative) among Southern Han Chinese women, we genotyped rs1078806, rs1219648, rs2420946, rs2981579, and rs2981582 polymorphisms in 609 patients and 882 controls. Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03–1.39), 1.24 (1.07–1.43), and 1.17 (1.01–1.36), respectively. In subtype specific analysis, above three SNPs were significantly associated with increased Luminal-A risk in a dose-dependent mannerPtrend<0.01; however, only rs2981579 was associated with Luminal-B, and none were linked to ER−&PR− subtypes (ER−&PR−&HER2+ and triple negative). Haplotype analyses also identified common haplotypes significantly associated with luminal-like subtypes (Luminal-A and Luminal-B), but not with ER−&PR− subtypes. Our results suggest that associations ofFGFR2SNPs with breast cancer were heterogeneous according to intrinsic subtype. Future studies stratifying patients by their intrinsic subtypes will provide new insights into the complex genetic mechanisms underlying breast cancer.

scholarly journals Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

2016 ◽  
Vol Volume 10 ◽  
pp. 2359-2367 ◽  
Author(s):  
Zhi-Jun Dai ◽  
Zheng Wang ◽  
Xi-Jing Wang ◽  
Tian-Bo Jin ◽  
Zhi-Ming Dai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Han Chinese ◽  
Distinct Role

scholarly journals Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women

2015 ◽  
Vol 16 (2) ◽  
pp. 4121-4135 ◽  
Author(s):  
Min-Ying Sun ◽  
Hong-Yan Du ◽  
An-Na Zhu ◽  
Hui-Ying Liang ◽  
Gorka de Garibay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphisms ◽  
Chinese Women ◽  
Han Chinese

scholarly journals Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Fa-liang Wang ◽  
Xiao-li Zhang ◽  
Ming Yang ◽  
Jun Lin ◽  
Yong-fang Yue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Southern China ◽  
Meta Analysis ◽  
Northern China ◽  
Cancer Tissue ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Breast Fibroadenoma ◽  
Cancer Tissues

Abstract Background Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalence of MMTV-LV in women breast cancer tissue varies in different countries and its dependent factors remain inconclusive. Methods In the first part of the study, a case-control study was performed. 119 breast cancer samples (84 from Northern China and 35 from Southern China) and 50 breast fibroadenoma specimens were collected from Chinese women patients. MMTV-like env sequence and the homology to MMTV env gene were analysed by semi-nested polymerase chain reaction (PCR). We also explored the association of MMTV-LV prevalence with sample sources (Southern and Northern China) and patients’ clinicopathological characteristics. To investigate the dependent factors of the prevalence of MMTV-LV in breast cancer worldwide, a meta-analysis was conducted in the second part of the study. Results We found that the prevalence of MMTV-LV was much higher in breast cancer tissues (17.65%) than that in breast fibroadenoma specimens (4.00%) (P < 0.05). MMTV-LV prevalence in Chinese women breast cancer tissues was significantly different between Southern China (5.71%) and Northern China (22.62%) (P < 0.05). The prevalence of MMTV-LV also associates significantly with expression of HER2, but shows no significant correlation with other parameters. In the meta-analysis, we found that MMTV-LV prevalence in breast cancer tissue was dependent on the distribution of M. domesticus mouse (M. d), M. musculus mouse (M.m) and M.castaneus mouse (M.c) worldwide (P < 0.05). Conclusion The distribution of house mice may be a crucial environmental factor that explains the geographic differences in human breast cancer incidence. Our findings may provide a potential avenue of prevention, diagnosis and treatment for breast cancer.

scholarly journals Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer

Hereditas ◽  
2019 ◽  
Vol 157 (1) ◽  
Author(s):  
Yu Wu ◽  
Huanhuan Zhang ◽  
Xiaoling Weng ◽  
Honglian Wang ◽  
Qinghua Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Gene Mutations ◽  
Pathogenic Mutation ◽  
Han Chinese ◽  
Clinicopathological Parameters ◽  
Healthy Controls ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Increased Risk

Abstract Background Breast cancer is a one of the malignant carcinomas partially caused by genetic risk factors. Germline BRCA1 gene mutations are reportedly associated with breast cancers. Identification of BRCA1 mutations greatly improves the preventive strategies and management of breast cancer. The aim of our study was to investigate the frequency of the deleterious BRCA1: p.Ile1845fs variant in breast carcinomas, as well as the correlation between p.Ile1845fs variant with clinicopathological parameters and clinical outcomes. Results A total of 23,481 clinically high-risk patients with breast cancer and 6489 healthy controls were recruited for p.Ile1845fs variant sequencing (either sanger or next generation sequencing). We identified 94 breast cancer patients (0.40%, 94/23481) as well as 11 healthy controls (0.17%, 11/6489) carried p.Ile1845fs variant. BRCA1: p.Ile1845fs variant showed a higher frequency in patients with TNBC molecular typing (20.21%, 19/94) and family history (37.23%, 35/94) compared with non-carriers (P = 3.62E-6 and 0.034, respectively). According to our data, we advanced the frequency of p.Ile1845fs variant and we confirmed that BRCA1: p.Ile1845fs variant was associated with increased risk of breast cancer (OR = 2.36, 95%CI = 1.26–4.89, P = 0.004). Conclusions BRCA1: p.Ile1845fs variant was a frequently pathogenic mutation in breast cancer in Han Chinese women and our data may be helpful for diagnosis and therapy of breast cancer.

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