scholarly journals Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women

2015 ◽  
Vol 16 (2) ◽  
pp. 4121-4135 ◽  
Author(s):  
Min-Ying Sun ◽  
Hong-Yan Du ◽  
An-Na Zhu ◽  
Hui-Ying Liang ◽  
Gorka de Garibay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphisms ◽  
Chinese Women ◽  
Han Chinese

Abstract 891: Association of genetic polymorphisms of SIPA1 with breast cancer risk and survival among Chinese women

2010 ◽  
Author(s):  
Shimian Qu ◽  
Hui Cai ◽  
Jirong Long ◽  
Qiuyin Cai ◽  
Regina Courtney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Chinese Women

scholarly journals Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kai Wang ◽  
Guanying Wang ◽  
Shangke Huang ◽  
Anqi Luo ◽  
Xin Jing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Chinese Women ◽  
Han Chinese

A Cross-Sectional Study of Associations Between Nonsynonymous Mutations of the BARD1 Gene and Breast Cancer in Han Chinese Women

2013 ◽  
Vol 25 (4_suppl) ◽  
pp. 8S-14S ◽  
Author(s):  
Hui Liu ◽  
Hengwei Zhang ◽  
Xianfu Sun ◽  
Yaning He ◽  
Juntao Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals A case-control study on risk factors of breast cancer in Han Chinese women

Oncotarget ◽  
2017 ◽  
Vol 8 (57) ◽  
pp. 97217-97230 ◽  
Author(s):  
Li-Yuan Liu ◽  
Fei Wang ◽  
Shu-De Cui ◽  
Fu-Guo Tian ◽  
Zhi-Min Fan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Han Chinese ◽  
Control Study

scholarly journals TCF21 genetic polymorphisms and breast cancer risk in Chinese women

Oncotarget ◽  
2016 ◽  
Vol 7 (34) ◽  
pp. 55757-55764 ◽  
Author(s):  
Xueren Gao ◽  
Jiaojiao Yang ◽  
Mingxi Wang ◽  
Jianqiong Zhang
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Chinese Women

scholarly journals Heterogeneity of Breast Cancer Associations with Common Genetic Variants inFGFR2according to the Intrinsic Subtypes in Southern Han Chinese Women

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Huiying Liang ◽  
Xuexi Yang ◽  
Lujia Chen ◽  
Hong Li ◽  
Anna Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Chinese Women ◽  
Intrinsic Subtype ◽  
Han Chinese ◽  
Dependent Manner ◽  
Intrinsic Subtypes ◽  
Luminal A ◽  
Luminal B ◽  
Common Genetic Variants

GWAS have identified variation in theFGFR2locus as risk factors for breast cancer. Validation studies, however, have shown inconsistent results by ethnics and pathological characteristics. To further explore this inconsistency and investigate the associations ofFGFR2variants with breast cancer according to intrinsic subtype (Luminal-A, Luminal-B, ER−&PR−&HER2+, and triple negative) among Southern Han Chinese women, we genotyped rs1078806, rs1219648, rs2420946, rs2981579, and rs2981582 polymorphisms in 609 patients and 882 controls. Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03–1.39), 1.24 (1.07–1.43), and 1.17 (1.01–1.36), respectively. In subtype specific analysis, above three SNPs were significantly associated with increased Luminal-A risk in a dose-dependent mannerPtrend<0.01; however, only rs2981579 was associated with Luminal-B, and none were linked to ER−&PR− subtypes (ER−&PR−&HER2+ and triple negative). Haplotype analyses also identified common haplotypes significantly associated with luminal-like subtypes (Luminal-A and Luminal-B), but not with ER−&PR− subtypes. Our results suggest that associations ofFGFR2SNPs with breast cancer were heterogeneous according to intrinsic subtype. Future studies stratifying patients by their intrinsic subtypes will provide new insights into the complex genetic mechanisms underlying breast cancer.

scholarly journals Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

2016 ◽  
Vol Volume 10 ◽  
pp. 2359-2367 ◽  
Author(s):  
Zhi-Jun Dai ◽  
Zheng Wang ◽  
Xi-Jing Wang ◽  
Tian-Bo Jin ◽  
Zhi-Ming Dai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Han Chinese ◽  
Distinct Role
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