scholarly journals Risk-Association of Five SNPs in TOX3/LOC643714 with Breast Cancer in Southern China

2014 ◽  
Vol 15 (2) ◽  
pp. 2130-2141 ◽  
Author(s):  
Xuanqiu He ◽  
Guangyu Yao ◽  
Fenxia Li ◽  
Ming Li ◽  
Xuexi Yang
Keyword(s):  
Breast Cancer ◽  
Southern China ◽  
Risk Association

scholarly journals Risk-Association of CYP11A1 Polymorphisms and Breast Cancer Among Han Chinese Women in Southern China

2012 ◽  
Vol 13 (4) ◽  
pp. 4896-4905 ◽  
Author(s):  
Minying Sun ◽  
Xuexi Yang ◽  
Changsheng Ye ◽  
Weiwen Xu ◽  
Guangyu Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Southern China ◽  
Han Chinese ◽  
Risk Association

scholarly journals Distribution, clinicopathologic features and survival of breast cancer subtypes in Southern China

2012 ◽  
Vol 103 (9) ◽  
pp. 1679-1687 ◽  
Author(s):  
Cong Xue ◽  
Xi Wang ◽  
Roujun Peng ◽  
Yanxia Shi ◽  
Tao Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Southern China ◽  
Breast Cancer Subtypes ◽  
Clinicopathologic Features ◽  
Cancer Subtypes

scholarly journals What is breast density?

2005 ◽  
Vol 8 (10) ◽  
Author(s):  
C. Byrne ◽  
S. Spernak
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Research ◽  
Breast Cancer Risk ◽  
Breast Density ◽  
Brca2 Mutation ◽  
Indirect Evidence ◽  
Epithelial Proliferation ◽  
Estrogen Exposure ◽  
Risk Association

Although having increased breast density is one of the strongest risk factors for breast cancer other than increased age and having a BRCA1 or BRCA2 mutation, it is still not clearly understood what that measure of risk is reflecting biologically. It has long been presumed based on indirect evidence that breast density is an indicator of cumulative hormone, particularly estrogen, exposure throughout one's life. However, there is growing evidence that the story may not be that simple. Recent studies suggest that stromal and epithelial proliferation and interaction, and the IGH-axis may all be involved in explaining the breast density and breast cancer risk association. Clearly for breast cancer research to advance it will be necessary to think beyond the presumed association that explains breast density only through estrogen pathways.

scholarly journals Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Fa-liang Wang ◽  
Xiao-li Zhang ◽  
Ming Yang ◽  
Jun Lin ◽  
Yong-fang Yue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Southern China ◽  
Meta Analysis ◽  
Northern China ◽  
Cancer Tissue ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Breast Fibroadenoma ◽  
Cancer Tissues

Abstract Background Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalence of MMTV-LV in women breast cancer tissue varies in different countries and its dependent factors remain inconclusive. Methods In the first part of the study, a case-control study was performed. 119 breast cancer samples (84 from Northern China and 35 from Southern China) and 50 breast fibroadenoma specimens were collected from Chinese women patients. MMTV-like env sequence and the homology to MMTV env gene were analysed by semi-nested polymerase chain reaction (PCR). We also explored the association of MMTV-LV prevalence with sample sources (Southern and Northern China) and patients’ clinicopathological characteristics. To investigate the dependent factors of the prevalence of MMTV-LV in breast cancer worldwide, a meta-analysis was conducted in the second part of the study. Results We found that the prevalence of MMTV-LV was much higher in breast cancer tissues (17.65%) than that in breast fibroadenoma specimens (4.00%) (P < 0.05). MMTV-LV prevalence in Chinese women breast cancer tissues was significantly different between Southern China (5.71%) and Northern China (22.62%) (P < 0.05). The prevalence of MMTV-LV also associates significantly with expression of HER2, but shows no significant correlation with other parameters. In the meta-analysis, we found that MMTV-LV prevalence in breast cancer tissue was dependent on the distribution of M. domesticus mouse (M. d), M. musculus mouse (M.m) and M.castaneus mouse (M.c) worldwide (P < 0.05). Conclusion The distribution of house mice may be a crucial environmental factor that explains the geographic differences in human breast cancer incidence. Our findings may provide a potential avenue of prevention, diagnosis and treatment for breast cancer.

Male Breast Cancer: A Population-Based Comparison with Female Breast Cancer in Hong Kong, Southern China: 1997–2006

2013 ◽  
Vol 21 (4) ◽  
pp. 1246-1253 ◽  
Author(s):  
Ava Kwong ◽  
◽  
Wai Wang Chau ◽  
Oscar W. K. Mang ◽  
Connie H. N. Wong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hong Kong ◽  
Male Breast Cancer ◽  
Southern China ◽  
Population Based ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Female Breast
Sign in / Sign up

Export Citation Format

Share Document