scholarly journals Human Milk Glucocorticoid Levels Are Associated With Infant Adiposity and Head Circumference Over the First Year of Life

2020 ◽  
Vol 7 ◽  
Author(s):  
Shikha Pundir ◽  
Zoya Gridneva ◽  
Avinesh Pillai ◽  
Eric B. Thorstensen ◽  
Clare R. Wall ◽  
...  
2018 ◽  
Vol 41 (05) ◽  
pp. 544-549 ◽  
Author(s):  
Ladina Vonzun ◽  
Franziska Maria Winder ◽  
Martin Meuli ◽  
Ueli Moerlen ◽  
Luca Mazzone ◽  
...  

Abstract Purpose The aim of this study was to describe the sonographic evolution of fetal head circumference (HC) and width of the posterior horn of the lateral ventricle (Vp) after open fetal myelomeningocele (fMMC) repair and to assess whether pre- or postoperative measurements are helpful to predict the need for shunting during the first year of life. Patients & Methods All 30 children older than one year by January 2017 who previously had fMMC repair at the Zurich Center for Fetal Diagnosis and Therapy were included. Sonographic evolution of fetal HC and Vp before and after fMMC repair was assessed and compared between the non-shunted (N = 16) and the shunted group (N = 14). ROC curves were generated for the fetal HC Z-score and Vp in order to show their predictive accuracy for the need for shunting until 1 year of age. Results HC was not an independent factor for predicting shunting. However, the need for shunting was directly dependent on the preoperative Vp as well as the Vp before delivery. A Vp > 10 mm at evaluation for fMMC repair or > 15 mm before delivery identifies 100 % of the infants needing shunt placement at a false-positive rate of 44 % and 25 %, respectively. All fetuses with a Vp > 15 mm at first evaluation received a shunt. Conclusion Fetuses demonstrating a Vp of > 15 mm before in utero MMC repair are extremely likely to develop hydrocephalus requiring a shunt during the first year of life. This compelling piece of evidence must be appropriately integrated into prenatal counseling.


Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1124 ◽  
Author(s):  
Sergio Verd ◽  
Gemma Ginovart ◽  
Javier Calvo ◽  
Jaume Ponce-Taylor ◽  
Antoni Gaya

The aim of this review is to evaluate changes in protein parameters in the second year postpartum. There is considerable agreement among authors about the declining trend of human milk protein concentrations, but most research on protein content in breast milk focuses on the first year of life and comes from developed countries. Whereas this is the case for exclusive breastfeeding or for breastfeeding into the first year of life, the opposite applies to weaning or extended breastfeeding. This review is predominantly based on observational epidemiological evidence and on comparative research linking breast milk composition with cutting down on breastfeeding. Studies dating back several decades have shown an increase in the proportion of immunoglobulins, lactoferrin, and serum albumin during weaning. According to the limited data available, it seems likely that the regulation of milk protein composition during involution can be ascribed to alterations in tight junctions. In studies on humans and other mammalian species, offspring suckle more from mothers that produce more dilute milk and the increase in milk protein concentration is positively correlated to a decrease in suckling frequency during weaning. High milk protein contents were first reported in nonindustrial communities where breastfeeding is sustained the longest, but recent papers from urbanized communities have taken credit for rediscovering the increase in protein content of human milk that becomes evident with prolonged breastfeeding. This review presents an overview of the changes in breast milk protein parameters in the second year postpartum to enable milk banks’ practitioners to make informed nutritional decisions on preterm infants.


1993 ◽  
Vol 122 (3) ◽  
pp. 348-354 ◽  
Author(s):  
Francis Mimouni ◽  
Barbara Campaigne ◽  
Michael Neylan ◽  
Reginald C. Tsang

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1125 ◽  
Author(s):  
Zoya Gridneva ◽  
Sambavi Kugananthan ◽  
Alethea Rea ◽  
Ching Lai ◽  
Leigh Ward ◽  
...  

Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n = 20) was measured at 2, 5, 9, and/or 12 months postpartum with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers). 24-h milk intake and feeding frequency were measured along with whole milk adiponectin and skim and whole milk leptin (SML and WML) and CDI were calculated. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Adipokine concentrations did not associate with infant BC. Higher CDI of adiponectin were associated with lower infant fat-free mass (FFM; p = 0.005) and FFM index (FFMI; p = 0.009) and higher fat mass (FM; p < 0.001), FM index (FMI; p < 0.001), and %FM (p < 0.001). Higher CDI of SML were associated with higher infant FM (p < 0.001), FMI (p < 0.001), and %FM (p = 0.002). At 12 months, higher CDI of WML were associated with larger increases in infant adiposity (2–12 month: FM, p = 0.0006; %FM, p = 0.0004); higher CDI of SML were associated with a larger decrease in FFMI (5–12 months: p = 0.0004). Intakes of HM adipokines differentially influence development of infant BC in the first year of life, which is a critical window of infant programming and may potentially influence risk of later disease via modulation of BC.


2004 ◽  
Vol 56 (11) ◽  
pp. 892-894 ◽  
Author(s):  
E. Fuller Torrey ◽  
Dawn Dhavale ◽  
John P. Lawlor ◽  
Robert H. Yolken

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Caroline Dupont ◽  
Natalie Castellanos-Ryan ◽  
Jean R. Séguin ◽  
Gina Muckle ◽  
Marie-Noëlle Simard ◽  
...  

2017 ◽  
pp. 44-49
Author(s):  
A. A. Kozlovsky ◽  
V. A. Melnik ◽  
E. V. Kurashevich ◽  
A. A. Kozlovsky1 (Jr) ◽  
E. O. Lopatenko

Aim of research: to carry out comparative assessment of monthly gains of length, body mass, head circumference, and chest circumference in healthy full-term infants during their first year of life receiving different types of feeding. Material and methods of research. We have analyzed monthly gains of the basic parameters of physical development of 200 full-term infants by the results of the retrospective survey of histories of infant development performed at Branch No. 3 of state health institution «Gomel City Central Children`s Out-Patient Clinic». Results. We have revealed accelerated gains of body mass, head circumference, and chest circumference in the first quarter and some lag of these parameters in other periods (as compared to the parameters recommended by the WHO). At the same time, the gain of body length practically did not differ from the standard one. On the whole, the average gains of body mass and body length, head circumference, and chest circumference in most the infants by 12 months did not differ from the standard ones. Only the girls receiving artificial feeding noted an inadequate gain of body length in comparison with the standard one (22.34 and 25 см correspondingly; -10.6 %), and those who were receiving natural feeding detected a decrease of the average gain of chest circumference by 10.4 %. Conclusion. We have found uneven rates of gains of the basic parameters of physical development in contemporary infants during their first year of life which do not depend on the type of feeding.


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