scholarly journals Variation in the Protein Composition of Human Milk during Extended Lactation: A Narrative Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1124 ◽  
Author(s):  
Sergio Verd ◽  
Gemma Ginovart ◽  
Javier Calvo ◽  
Jaume Ponce-Taylor ◽  
Antoni Gaya
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Protein Content ◽  
Milk Protein ◽  
Mammalian Species ◽  
Protein Composition ◽  
Developed Countries ◽  
First Year ◽  
Second Year ◽  
First Year Of Life

The aim of this review is to evaluate changes in protein parameters in the second year postpartum. There is considerable agreement among authors about the declining trend of human milk protein concentrations, but most research on protein content in breast milk focuses on the first year of life and comes from developed countries. Whereas this is the case for exclusive breastfeeding or for breastfeeding into the first year of life, the opposite applies to weaning or extended breastfeeding. This review is predominantly based on observational epidemiological evidence and on comparative research linking breast milk composition with cutting down on breastfeeding. Studies dating back several decades have shown an increase in the proportion of immunoglobulins, lactoferrin, and serum albumin during weaning. According to the limited data available, it seems likely that the regulation of milk protein composition during involution can be ascribed to alterations in tight junctions. In studies on humans and other mammalian species, offspring suckle more from mothers that produce more dilute milk and the increase in milk protein concentration is positively correlated to a decrease in suckling frequency during weaning. High milk protein contents were first reported in nonindustrial communities where breastfeeding is sustained the longest, but recent papers from urbanized communities have taken credit for rediscovering the increase in protein content of human milk that becomes evident with prolonged breastfeeding. This review presents an overview of the changes in breast milk protein parameters in the second year postpartum to enable milk banks’ practitioners to make informed nutritional decisions on preterm infants.

scholarly journals Effect of milk protein content in Toddler formula on later BMI and obesity risk: protocol of the multicentre randomised controlled Toddler Milk Intervention (ToMI) trial

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e048290
Author(s):  
Veit Grote ◽  
Vanessa Jaeger ◽  
Joaquin Escribano ◽  
Marta Zaragoza ◽  
Mariona Gispert ◽  
...  
Keyword(s):  
Weight Gain ◽  
Protein Content ◽  
Milk Protein ◽  
First Year ◽  
Obesity Risk ◽  
Milk Protein Content ◽  
Second Year Of Life ◽  
Second Year ◽  
First Year Of Life

IntroductionReduction of milk protein content in infant formula provided during the first year of life has been shown to reduce early weight gain and obesity later in life. While rapid weight gain during the first 2 years of life is one of the strongest early predictors of obesity, the role of animal protein intake beyond the first year of life is unclear. The aim of this study is to examine the role of milk protein during the second year of life in healthy children on weight gain and obesity risk in preschool age.Methods and analysisThis randomised, double-blinded study enrolled 1618 children aged 11.5–13.5 months in Spain and Germany into two groups receiving isocaloric toddler milk with differing protein content during the second year of life. The experimental formula contains 1.5 g/100 kcal and the control formula 6.15 g/100 kcal protein and otherwise equal formula composition, except for modified fat content to achieve equal energy density. The primary endpoint is body mass index (BMI)-for-age z-score at the age of 24 months adjusted for BMI at 12 months of age. The children are followed until 6 years of age.Ethics and disseminationEthics approval was obtained from the ethical committees of the LMU University Hospital Munich, Germany (Nr. 555-15) and at Institut d’Investigació Sanitaria Pere Virgili, Reus, Spain (Ref. CEIm IISPV 013/2016). We aim at publishing results in peer-reviewed journals and sharing of results with study participants.Trial registration numberNCT02907502.

Hospital Maternal Care Is Disruptive

PEDIATRICS ◽  
1976 ◽  
Vol 57 (2) ◽  
pp. 294-295
Author(s):  
Justin D. Call
Keyword(s):  
Breast Milk ◽  
Breast Feeding ◽  
Maternal Care ◽  
Respiratory Infections ◽  
Mammalian Species ◽  
Smooth Transition ◽  
First Year ◽  
First Year Of Life

"Breast-Feeding: Second Thoughts" by Gerrard,1 sets forth epidemiologic and immunological data on human and other mammalian species showing that colostrum and breast milk actively protect the infant from enterocolitis and respiratory infections when breast-feeding is begun immediately after birth and continued through at least most of the first year of life. Gerrard hypothesizes that breast-feeding provides a smooth transition for the baby from being entirely dependent on the mother for nutritional and immunological requirements to being completely independent from her.

The Use of Cow's Milk in Infancy

PEDIATRICS ◽  
1993 ◽  
Vol 91 (2) ◽  
pp. 515-515
Author(s):  
WM. LANE M. ROBSON ◽  
ALEXANDER K. C. LEUNG
Keyword(s):  
Breast Milk ◽  
Milk Protein ◽  
Cow’S Milk ◽  
First Year ◽  
Infant Formulas ◽  
Cow's Milk ◽  
American Academy Of Pediatrics ◽  
Cow’S Milk Protein ◽  
First Year Of Life ◽  
Diabetes Mellitus 2

To the Editor.— In June 1992, the Committee on Nutrition of the American Academy of Pediatrics recommended that if breast-feeding is not possible then an infant formula is the appropriate alternative, and that cow's milk is not suitable as an alternative to breast milk for the first year of life.1 We agree with this recommendation and with the rationale included in the June 1992 statement. In lieu of the recent evidence that cow's milk protein may be implicated in the pathogenesis of diabetes mellitus,2 we believe that the Committee on Nutrition should clarify whether cow's milk is ever appropriate for children and whether or not infant formulas that are based on cow's milk protein are appropriate alternatives to breast milk.

scholarly journals The use of biological fabaceae resources of the cretaceous south of Russia in breeding on the example of the species Melilotus albus medik

2021 ◽  
Vol 39 ◽  
pp. 02007
Author(s):  
V.M. Kosolapov ◽  
V.I. Cherniavskih ◽  
E.V. Dumacheva ◽  
L.M. Tseiko
Keyword(s):  
Protein Content ◽  
Genetic Material ◽  
Fiber Content ◽  
High Yield ◽  
First Year ◽  
Biological Traits ◽  
Wild Populations ◽  
Standard Level ◽  
Second Year ◽  
First Year Of Life

The morpho-biological traits of the breeding sample POD 17/13, created on the basis of genetic material of wild populations of M. albus of the Cretaceous south of the Central Russian Upland, were evaluated in comparison with the well-known zoned variety “Obskoy gigant”. The purpose of breeding work is to obtain a combination in one genotype of high yield traits of feed mass and leaf coverage; high protein content and low fiber content while maintaining seed productivity at the standard level. Three sets of field experiment were carried out: in 2016, 2017 and 2018. The setting years were the first years of life for the biennial M. albus crop. Individuals of the POD 17/13 breeding sample tend to increase the length of the growing season: by an average of 3.7 days in the first year of life, and by 7.3 days in the second year. According to the seed yield, the breeding sample M. albus POD 17/13 is at the standard level. In terms of protein content, the POD 17/13 variety significantly exceeds the standard in the first year of life by 6.8…9.2%, in the second - by 15.1…19.2%. At the same time, its herbage is more tender, since the fiber content in the aboveground mass is lower than that of the standard – in the first year of life – by 2.1…7.1%, in the second year of life - 6.9…9.9%. Thus, the POD 17/13 variety sample, created on the basis of the source material of wild populations of M. albus, is promising for obtaining a new variety based on it.

Gastric electrical activity in normal neonates during the first year of life. Effect of lactation with breast milk and formula

2001 ◽  
Vol 120 (5) ◽  
pp. A209-A209
Author(s):  
G RIEZZO ◽  
R CASTELLANA ◽  
T DEBELLIS ◽  
F LAFORGIA ◽  
F INDRIO ◽  
...  
Keyword(s):  
Breast Milk ◽  
Electrical Activity ◽  
First Year ◽  
Gastric Electrical Activity ◽  
First Year Of Life ◽  
Normal Neonates

An inevitable crisis? From first to second year in counsellor training

2020 ◽  
Vol 5 (1) ◽  
pp. 74-89
Author(s):  
Hugh Crago
Keyword(s):  
Right Hemisphere ◽  
Training Programme ◽  
First Year ◽  
Training Experience ◽  
Counsellor Training ◽  
Student Dropout ◽  
Second Year ◽  
Neurological Research ◽  
First Year Of Life ◽  
And Control

In a seminal 1973 paper, Robert Clark described the very different “cultures” of the first and second year students in a four year clinical psychology PhD programme. The author applies Clark’s template to his own experiences as trainee or trainer in five different counsellor education programmes, one in the US and four in Australia. Each of the programmes, to varying degrees, demonstrates key features of the pattern identified by Clark, where the first year is “therapeutic” and other-oriented, the second is “professional” and self-focused. The author concludes that all the surveyed programmes exhibited some level of “second year crisis”, in which a significant number of students felt abandoned, dissatisfied, or rebellious. The author extends and refines Clark’s developmental analogy (first year = childhood; second year = adolescence) to reflect recent neurological research, in particular, the shift from a right hemisphere-dominant first year of life, prioritising affiliative needs, to a left hemisphere-dominant second year, prioritising autonomy and control. This shift is paralleled later by a more gradual move from a protective, supportive childhood to necessary, but sometimes conflictual, individuation in adolescence. The first two years of a counsellor training programme broadly echo this process, a process exacerbated by the second year internship/placement, in which students must “leave home” and adjust to unfamiliar, potentially less nurturing, authority figures. Finally, the author suggests introducing more rigorous “academic holding” into the first year, and greater attention to “therapeutic holding” of dissident students in the second, hopefully decreasing student dropout, and achieving a better balanced training experience.

scholarly journals Effect of breast milk of diabetic mothers on bodyweight of the offspring in the first year of life

2004 ◽  
Vol 58 (10) ◽  
pp. 1429-1431 ◽  
Author(s):  
A Kerssen ◽  
I M Evers ◽  
H W de Valk ◽  
G H A Visser
Keyword(s):  
Breast Milk ◽  
First Year ◽  
First Year Of Life ◽  
Diabetic Mothers

Human Breast Milk Contains Bovine lgG. Relationship to Infant Colic?

PEDIATRICS ◽  
1991 ◽  
Vol 87 (4) ◽  
pp. 439-444
Author(s):  
Patrick S. Clyne ◽  
Anthony Kulczycki
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cow's Milk ◽  
Milk Samples ◽  
Infant Colic ◽  
Β Lactoglobulin

Previous studies have suggested that an unidentified cow's milk protein, other than β-lactoglobulin and casein, might play a pathogenetic role in infant colic. Therefore, a radioimmunoassay was used to analyze human breast milk and infant formula samples for the presence of bovine IgG. Milk samples from 88 of the 97 mothers tested contained greater than 0.1 µg/mL of bovine IgG. In a study group of 59 mothers with infants in the colic-prone 2- to 17-week age group, the 29 mothers of colicky infants had higher levels of bovine IgG in their breast milk (median 0.42 µg/mL) than the 30 mothers of noncolicky infants (median 0.32 µg/mL) (P < .02). The highest concentrations of bovine IgG observed in human milk were 8.5 and 8.2 µg/mL. Most cow's milk-based infant formulas contained 0.6 to 6.4 µg/mL of bovine IgG, a concentration comparable with levels found in many human milk samples. The results suggest that appreciable quantities of bovine IgG are commonly present in human milk, that significantly higher levels are present in milk from mothers of colicky infants, and that bovine IgG may possibly be involved in the pathogenesis of infant colic.

scholarly journals Safety of potential breast milk exposure to IFN-β or glatiramer acetate

2020 ◽  
Vol 7 (4) ◽  
pp. e757
Author(s):  
Andrea Ines Ciplea ◽  
Annette Langer-Gould ◽  
Anna Stahl ◽  
Sandra Thiel ◽  
Annette Queisser-Wahrendorf ◽  
...  
Keyword(s):  
Breast Milk ◽  
Glatiramer Acetate ◽  
Growth Curves ◽  
Antibiotic Use ◽  
Physical Growth ◽  
First Year ◽  
Motor Delay ◽  
Infant Outcomes ◽  
First Year Of Life

ObjectiveTo determine whether potential breast milk exposure to interferon-beta (IFN-β) or glatiramer acetate (GA) is safe for the infant.MethodsWe identified 74 infants born to 69 women with MS who breastfed under IFN-β (n = 39), GA (n = 34), or both (n = 1). Women had been enrolled into the German Multiple Sclerosis and Pregnancy Registry during pregnancy. Data were obtained from standardized, telephone-administered questionnaires completed by the mother during pregnancy and at 1, 3, 6, and 12 months postpartum and the infant's take-home medical record.ResultsThe median duration of exposed breastfeeding was 8.5 months (wide interquartile range: 4.9–12.7 months). Physical growth curves during the first year of life were consistent with national, sex-specific growth curves. Median body measurements were consistent with national medians. Most children (n = 71, 96%) had normal motor and language development. Gross motor delay was reported in 3 children, of whom 1 remained delayed at last follow-up (3.9 years old) and 2 were normal by 0.9 and 4.1 years old. The proportion of children hospitalized at least once (girls n = 2, 7%, and boys n = 6, 14%) and the proportion of children with at least one episode of systemic antibiotic use during the first year of life (girls n = 7, 23%, and boys n = 8, 18%) are consistent with national averages.ConclusionPotential breast milk exposure to IFN-β or GA did not increase the risk of common adverse infant outcomes in the first year of life. Taken together with the benefits of breastfeeding and low biological plausibility of risk, women with MS who wish to resume IFN-β or GA postpartum can be encouraged to breastfeed.

scholarly journals Human Milk Glucocorticoid Levels Are Associated With Infant Adiposity and Head Circumference Over the First Year of Life

2020 ◽  
Vol 7 ◽  
Author(s):  
Shikha Pundir ◽  
Zoya Gridneva ◽  
Avinesh Pillai ◽  
Eric B. Thorstensen ◽  
Clare R. Wall ◽  
...  
Keyword(s):  
Human Milk ◽  
Head Circumference ◽  
First Year ◽  
First Year Of Life
Sign in / Sign up

Export Citation Format

Share Document