scholarly journals Acute toxic effects of hydrogen peroxide, used for salmon lice treatment, on the survival of polychaetes Capitella sp. and Ophryotrocha spp.

2018 ◽  
Vol 10 ◽  
pp. 363-368 ◽  
Author(s):  
J Fang ◽  
OB Samuelsen ◽  
Ø Strand ◽  
H Jansen
Keyword(s):  
Hydrogen Peroxide ◽  
Toxic Effects ◽  
Salmon Lice ◽  
Acute Toxic

Acute toxic effects of sodium selenate on the epiphyseal plate of the rat

1971 ◽  
Vol 7 (1) ◽  
pp. 318-330 ◽  
Author(s):  
Robert D. Campo ◽  
Robert J. Bielen
Keyword(s):  
Epiphyseal Plate ◽  
Toxic Effects ◽  
Sodium Selenate ◽  
Acute Toxic

scholarly journals UJI TOKSISITAS AKUT MINUMAN PROBIOTIK SIRSAK GUNUNG (Annona montana Macf.) DENGAN METODE BSLT (Brine Shrimp Lethality Test)

2020 ◽  
Vol 1 (5) ◽  
pp. 941-948
Author(s):  
Ambar Fidyasari ◽  
Sentot Joko Raharjo ◽  
Melani Setyowati
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Brine Shrimp ◽  
Experimental Methods ◽  
Test Method ◽  
Toxic Effects ◽  
Brine Shrimp Lethality ◽  
Lc50 Value ◽  
A Value ◽  
Acute Toxic

Soursop fruit (Annona montana Macf.) is one of the plants can be used as as traditional medicine. This plant contains terpenoid and acetogenin which can cause toxicity. The fruit has a flavor that is tasteless so the innovation becomes probiotic drinks. This drink has been proven as an antioxidant, antibacterial, antihyperuricemia and antidiarrheal. The aim of this study was to know about acute toxicity of probiotic drink of soursop juice using brine shrimp lethality test method which will be indicated by LC50 value. This study used experimental methods conducted in the Laboratory of Farmakoknosi. There are several variations in concentration in this study, namely 10000 ppm, 20000 ppm, 30000 ppm, 40000 ppm, 50000 ppm, 60000 ppm, 70000 ppm, 80000 ppm and replication was done 3 times with total number of test animals used was 270. The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm. LC50 values ​​indicate that the mountain soursop probiotic drink is not potentially toxic because it has a value of >1000 ppm.

scholarly journals Toxic effects of oxygen and of hydrogen peroxide on brain metabolism

1946 ◽  
Vol 40 (1) ◽  
pp. 139-144 ◽  
Author(s):  
P. J. G. Mann ◽  
J. H. Quastel
Keyword(s):  
Hydrogen Peroxide ◽  
Brain Metabolism ◽  
Toxic Effects

Acute toxic effects of a novel cyanobacterial toxin on the crustaceans Artemia salina and Daphnia pulex

1995 ◽  
Vol 133 (1) ◽  
pp. 61-69
Author(s):  
Marko Reinikainen ◽  
Jari Kiviranta ◽  
Veikko Ulvi ◽  
Marja-Leena Niku-Paavola
Keyword(s):  
Daphnia Pulex ◽  
Artemia Salina ◽  
Toxic Effects ◽  
Cyanobacterial Toxin ◽  
Acute Toxic

Acute toxic effects caused by the co-exposure of nanoparticles of ZnO and Cu in rainbow trout

2019 ◽  
Vol 687 ◽  
pp. 24-33 ◽  
Author(s):  
David Hernández-Moreno ◽  
Ana Valdehita ◽  
Estefanía Conde ◽  
Isabel Rucandio ◽  
José María Navas ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Toxic Effects ◽  
Acute Toxic

Effects of Acute and Subchronic Exposure of Topically Applied Fullerene Extracts on the Mouse Skin

1993 ◽  
Vol 9 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Mark A. Nelson ◽  
Frederick E. Domann ◽  
G. Tim Bowden ◽  
Stephen B. Hooser ◽  
Quintus Fernando ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Mouse Skin ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Toxic Effects ◽  
Exposure Level ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Acute Toxic

The recent discovery that fullerenes (C60) can be produced in macroscopic quantities has sparked much interest in the chemistry of this unusual molecule. Concerns have also arose about the potential carcinogenic effects of this molecule. We have addressed the potential acute and subchronic toxic effects of fullerenes applied in benzene on the mouse skin. The acute toxic effects measured in this study included epidermal DNA synthesis and the induction of ornithine decarboxylase activity in the epidermis. At the topical dose of fullerenes used in these studies (i.e., 200 ug), we found no effect on either DNA synthesis or ornithine decarboxylase activity over a 72 hour time course after treatment. The subchronic effects of the fullerenes as a mouse skin tumor promoter was assessed by repeatedly applying the chemical to the skin after initiation with the polycyclic aromatic hydrocarbon, 7,12-dimethlybenz-anthracene (DMBA). Repeated administration of the fullerenes for up to 24 weeks post-initiation did not result in either benign or malignant skin tumor formation, whereas promotion with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the formation of benign skin tumors. Our data indicate that fullerenes applied in benzene at a likely industrial exposure level do not cause acute toxic effects on the mouse skin epidermis.

scholarly journals Factors Contributing to Hydrogen Peroxide Resistance in Streptococcus pneumoniae Include Pyruvate Oxidase (SpxB) and Avoidance of the Toxic Effects of the Fenton Reaction

2003 ◽  
Vol 185 (23) ◽  
pp. 6815-6825 ◽  
Author(s):  
Christopher D. Pericone ◽  
Sunny Park ◽  
James A. Imlay ◽  
Jeffrey N. Weiser
Keyword(s):  
Hydrogen Peroxide ◽  
Streptococcus Pneumoniae ◽  
Fenton Reaction ◽  
Bacterial Species ◽  
Atp Depletion ◽  
Host Cells ◽  
Toxic Effects ◽  
Aerobic Growth ◽  
Pyruvate Oxidase ◽  
Cytotoxic Effects

ABSTRACT Aerobic growth of Streptococcus pneumoniae results in production of amounts of hydrogen peroxide (H2O2) that may exceed 1 mM in the surrounding media. H2O2 production by S. pneumoniae has been shown to kill or inhibit the growth of other respiratory tract flora, as well as to have cytotoxic effects on host cells and tissue. The mechanisms allowing S. pneumoniae, a catalase-deficient species, to survive endogenously generated concentrations of H2O2 that are sufficient to kill other bacterial species is unknown. In the present study, pyruvate oxidase (SpxB), the enzyme responsible for endogenous H2O2 production, was required for survival during exposure to high levels (20 mM) of exogenously added H2O2. Pretreatment with H2O2 did not increase H2O2 resistance in the mutant, suggesting that SpxB activity itself is required, rather than an H2O2-inducible pathway. SpxB mutants synthesized 85% less acetyl-phosphate, a potential source of ATP. During H2O2 exposure, ATP levels decreased more rapidly in spxB mutants than in wild-type cells, suggesting that the increased killing of spxB mutants was due to more rapid ATP depletion. Together, these data support the hypothesis that S. pneumoniae SpxB contributes to an H2O2-resistant energy source that maintains viability during oxidative stress. Thus, SpxB is required for resistance to the toxic by-product of its own activity. Although H2O2-dependent hydroxyl radical production and the intracellular concentration of free iron were similar to that of Escherichia coli, killing by H2O2 was unaffected by iron chelators, suggesting that S. pneumoniae has a novel mechanism to avoid the toxic effects of the Fenton reaction.

Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects

2019 ◽  
Vol 107 ◽  
pp. 104407 ◽  
Author(s):  
Jocelene Filippin Cossetin ◽  
Evelyne da Silva Brum ◽  
Rosana Casoti ◽  
Camila Camponogara ◽  
Rafaela Castro Dornelles ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Toxic Effects ◽  
Anti Inflammatory ◽  
Acute Toxic
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