scholarly journals Toxic effects of oxygen and of hydrogen peroxide on brain metabolism

1946 ◽  
Vol 40 (1) ◽  
pp. 139-144 ◽  
Author(s):  
P. J. G. Mann ◽  
J. H. Quastel
Keyword(s):  
Hydrogen Peroxide ◽  
Brain Metabolism ◽  
Toxic Effects

scholarly journals Factors Contributing to Hydrogen Peroxide Resistance in Streptococcus pneumoniae Include Pyruvate Oxidase (SpxB) and Avoidance of the Toxic Effects of the Fenton Reaction

2003 ◽  
Vol 185 (23) ◽  
pp. 6815-6825 ◽  
Author(s):  
Christopher D. Pericone ◽  
Sunny Park ◽  
James A. Imlay ◽  
Jeffrey N. Weiser
Keyword(s):  
Hydrogen Peroxide ◽  
Streptococcus Pneumoniae ◽  
Fenton Reaction ◽  
Bacterial Species ◽  
Atp Depletion ◽  
Host Cells ◽  
Toxic Effects ◽  
Aerobic Growth ◽  
Pyruvate Oxidase ◽  
Cytotoxic Effects

ABSTRACT Aerobic growth of Streptococcus pneumoniae results in production of amounts of hydrogen peroxide (H2O2) that may exceed 1 mM in the surrounding media. H2O2 production by S. pneumoniae has been shown to kill or inhibit the growth of other respiratory tract flora, as well as to have cytotoxic effects on host cells and tissue. The mechanisms allowing S. pneumoniae, a catalase-deficient species, to survive endogenously generated concentrations of H2O2 that are sufficient to kill other bacterial species is unknown. In the present study, pyruvate oxidase (SpxB), the enzyme responsible for endogenous H2O2 production, was required for survival during exposure to high levels (20 mM) of exogenously added H2O2. Pretreatment with H2O2 did not increase H2O2 resistance in the mutant, suggesting that SpxB activity itself is required, rather than an H2O2-inducible pathway. SpxB mutants synthesized 85% less acetyl-phosphate, a potential source of ATP. During H2O2 exposure, ATP levels decreased more rapidly in spxB mutants than in wild-type cells, suggesting that the increased killing of spxB mutants was due to more rapid ATP depletion. Together, these data support the hypothesis that S. pneumoniae SpxB contributes to an H2O2-resistant energy source that maintains viability during oxidative stress. Thus, SpxB is required for resistance to the toxic by-product of its own activity. Although H2O2-dependent hydroxyl radical production and the intracellular concentration of free iron were similar to that of Escherichia coli, killing by H2O2 was unaffected by iron chelators, suggesting that S. pneumoniae has a novel mechanism to avoid the toxic effects of the Fenton reaction.

Toxic effects of hydrogen peroxide on corneal endothelium

1982 ◽  
Vol 2 (7) ◽  
pp. 451-458 ◽  
Author(s):  
Michael V. Riley ◽  
Frank J. Giblin
Keyword(s):  
Hydrogen Peroxide ◽  
Corneal Endothelium ◽  
Toxic Effects

Different Toxic Effects of Hydrogen Peroxide, Nitric Oxide, and Superoxide on Human, Pig, and Rat Islets of Langerhans

2009 ◽  
Vol 103 (S 02) ◽  
pp. 133-135 ◽  
Author(s):  
T. Wacker ◽  
H. Jahr ◽  
S. Weinand ◽  
H. Brandhorst ◽  
D. Brandhorst ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Islets Of Langerhans ◽  
Toxic Effects ◽  
Rat Islets ◽  
Rat Islets Of Langerhans

Alpha-ketoglutarate attenuates toxic effects of sodium nitroprusside and hydrogen peroxide in Drosophila melanogaster

2015 ◽  
Vol 40 (2) ◽  
pp. 650-659 ◽  
Author(s):  
Maria M. Bayliak ◽  
Halyna V. Shmihel ◽  
Maria P. Lylyk ◽  
Oksana M. Vytvytska ◽  
Janet M. Storey ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drosophila Melanogaster ◽  
Sodium Nitroprusside ◽  
Toxic Effects
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