scholarly journals Reticulocyte Volume Distribution Width Coefficient of Variation

2020 ◽  
Author(s):  
Keyword(s):  
Coefficient Of Variation ◽  
Volume Distribution ◽  
Distribution Width ◽  
Width Coefficient

scholarly journals Impacts of Mycoplasma loads and lung lesions on immune and hematological statuses of pigs in an eight-breed cross heterogeneous population

2020 ◽  
Vol 98 (8) ◽  
Author(s):  
Qing Zhang ◽  
Jing Li ◽  
Tao Huang ◽  
Yifeng Zhang ◽  
Wenwu Xu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Neutrophil Count ◽  
Lymphocyte Count ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Volume Distribution ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Lung Lesions

Abstract Developments of pulmonary diseases, often accompanied by infections of bacteria, severely affect the meat production and welfare of pigs. This study investigated 307 pigs at age of 240 d from an eight-breed cross reared under standardized housing conditions for associations among the extent of lung lesions, bacteria load inferred from 16S rRNA sequencing of bronchoalveolar lavage fluid, as well as 57 immune cells and 25 hematological traits. We showed that the pigs under study suffered substantial and varied lung lesions, and the Mycoplasma is the most associated bacteria genera. At a false discovery rate of 0.05 (FDR < 0.05), the severity of lung lesions were significantly associated with greater CD8+ to CD3+ cell ratio, neutrophil-to-lymphocyte ratio (NLR), and standard deviation of red blood cell volume distribution width (RDW-SD), and lower CD4−CD8−/CD3+, CD3+CD4−CD8−/PBMCs (peripheral blood mononuclear cells) and CD14−CD16−/PBMCs cell ratios, mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage, reflecting an status of inflammation, immune suppression, and hypoxia of the pigs accompanying the progression of the lung lesions. The Mycoplasma abundance showed positive correlations with neutrophil count, neutrophil count percentage, NLR, monocyte count, coefficient of variation in red blood cell volume distribution width , and RDW-SD, and negative correlations with mean corpuscular hemoglobin concentration, lymphocyte count, and lymphocyte count percentage; these correlations are largely consistent with those of lung lesions, supporting the comorbidity of lung lesions and Mycoplasma infection. We also observed nonlinear associations that sharp increases in neutrophil count and neutrophil count percentage occurred only when Mycoplasma abundance raised above the population-average level. The results provide helpful insights into the changes of host immune status in response to Mycoplasma relevant lung diseases in pigs.

scholarly journals Clinical importance of preoperative red-cell volume distribution width as a prognostic marker in patients undergoing radical surgery for pancreatic cancer

Surgery Today ◽  
2021 ◽  
Author(s):  
Chao Dang ◽  
Min Wang ◽  
Tingting Qin ◽  
Renyi Qin
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Nutritional Status ◽  
Cell Volume ◽  
Radical Surgery ◽  
Volume Distribution ◽  
Red Cell ◽  
Roc Curve Analysis ◽  
Distribution Width ◽  
Red Cell Volume

Abstract Background and purpose A new noninvasive biomarker is being sought to predict the prognosis of patients with pancreatic cancer. Red-cell volume distribution width (RDW), a descriptive parameter for erythrocyte variation, has been shown to have prognostic value for some tumor types. Our purpose was to assess the RDW value to predict the prognosis of patients with pancreatic cancer. Methods The subjects of this retrospective study were 792 patients who underwent radical surgery for pancreatic cancer, divided into high-RDW and low-RDW groups based on receiver operating characteristic (ROC) curve analysis (15.6%). The controlling nutritional status (CONUT) score was used to assess preoperative nutritional status. Statistical analysis was conducted to investigate the differences between the high and low RDW groups, and to explore the possibility of the RDW being used as prognostic predictor for patients with pancreatic cancer. Results The immune-nutritional status was worse in the high-RDW group than in the low-RDW group. The high-RDW group patients also had a poorer prognosis. Risk factor analysis showed that the RDW could be an independent risk factor for pancreatic cancer. Conclusions The RDW is associated with immune-nutritional status in pancreatic cancer patients and can be used as an independent prognostic factor for their postoperative survival.

scholarly journals Effect of Pegbovigrastim on Hematological Profile of Simmental Dairy Cows during the Transition Period

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 841 ◽  
Author(s):  
Francesca Trimboli ◽  
Valeria Maria Morittu ◽  
Antonio Di Loria ◽  
Andrea Minuti ◽  
Antonella Anna Spina ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Blood Cells ◽  
Transition Period ◽  
Lower Percentage ◽  
Control Group ◽  
Volume Distribution ◽  
Polymorphonuclear Cells ◽  
Distribution Width ◽  
Hematological Profile ◽  
First Time

Pegbovigrastim is a long-acting analog of recombinant bovine granulocyte colony-stimulating factor, that promotes and increases the count and functionality of polymorphonuclear cells in dairy cows. The present study aimed to explore, for the first time in Simmental cows, the clinical and hematological effect of pegbovigrastim during the transition period (TP). Cows were randomly assigned into two groups: treated group (PEG; n = 16) received pegbovigrastim at approximately 7 days before expected parturition and within 6 h after calving, and control group (CTR; n = 16) received saline solution. Blood samples were obtained at −7, 0, 1, 3, 7, 14, 21, and 30 days relative to calving. PEG group showed white blood cells (WBC) count consistently higher compared with CTR group (p < 0.001) until to 3 weeks after calving. Neutrophils remained higher in PEG group (p < 0.001) up to three weeks after calving, compared with CTR group, with slight increment of band cells. Moreover, PEG group displayed a lower index of myeloperoxidase at 1, 3, and 7 days after calving (p < 0.01) compared with CTR. Basophils and lymphocytes showed a similar trend to those observed for neutrophils at 1 day after calving in PEG group. Finally, monocytes remained markedly elevated until 3 days after calving in PEG compared to CTR group (p < 0.001), whereas in PEG group, eosinophils population showed lower percentage values at 1 and 3 days after calving but higher values at 30 days compared with CTR group. PEG group was characterized by lower red blood cells (RBCs) count compared with CTR group (p < 0.05) and higher % of red cell volume distribution width (RDW) from week 2 and mean corpuscular volume (MCV) at 30 days after calving. In addition, the mean platelet volume (MPV) was significantly higher in PEG group at calving, 1, 3, and 7 days after calving compared with CTR group (p < 0.05). For the first time, we described the effect of pegbovigrastim in a breed not specialized exclusively in milk production as Holstein, but with dual purpose (meat and milk), evaluating the complete hematological profile in cows during the transition period. These results provide evidence on the proliferative effect of pegbovigrastim on WBC in Simmental breed highlighting its possible side effect on RBCs.

A Renewed Focus on GDF11 Level Fluctuation in Human Serum in Relation to Physical Examination Indicators

2019 ◽  
Vol 75 (6) ◽  
pp. 1095-1102 ◽  
Author(s):  
Xiaolin Liang ◽  
Xiaowei Dou ◽  
Long Tian ◽  
Quanyang Li
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Volume Distribution ◽  
Monocyte Count ◽  
Blood Cell Count ◽  
Platelet Volume ◽  
Distribution Width ◽  
Age Range

Abstract Growth and differentiation factor 11 (GDF11) is a member of the transforming growth factor β superfamily. Previous studies have shown that GDF11 decreases with age and has antiaging effects; however, such reports are controversial. We choose 152 subjects covering a large age range (2 hours to 75 years) to measure serum GDF11. Twenty-two hematological variables and 13 biochemical values were measured. Pearson’s analysis found a significant correlation between GDF11 and age (p = .0000, r = .4898), as well as serum creatinine, uric acid, triglycerides, red blood cell count, hemoglobin, hematocrit, and platelet volume distribution width. GDF11 negatively correlated with aspartate transaminase, white blood cell count, platelet count, lymphocyte count, monocyte count, mean platelet volume, and plateletcrit. Interestingly, we found GDF11 increases in people aged 20–30 years, holds steady in people aged 30–50 years, and increases in people older than 50 years. The results suggest that GDF11 serves different roles along the life span. The current actual evidence supports that GDF11 is helpful to promote aging.

Red Blood Cell Volume Distribution Width (RDW) in Uraemic Patients on Chronic Haemodialysis

1989 ◽  
Vol 12 (3) ◽  
pp. 170-174 ◽  
Author(s):  
D. Docci ◽  
C. Delvecchio ◽  
C. Gollini ◽  
F. Turci ◽  
L. Baldrati ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Iron Status ◽  
Volume Distribution ◽  
Chronic Haemodialysis ◽  
Distribution Width ◽  
Iron Administration ◽  
Parallel Increase ◽  
Normal Individuals

Red blood cell volume distribution width (RDW) was obtained with the Coulter counter in 60 haemodialysis patients and 55 normal individuals. RDW tended to be higher in the former and the degree of increase was to some extent correlated with the underlying nephropathy. Although RDW failed to correlate with conventional tests of iron status, it was observed that iron administration could produce a decrease toward normal in RDW and a parallel increase in haemoglobin when the initial RDW was increased. In contrast, the response to iron was negligible in the patients with normal RDW basally. It was concluded that high RDW is an acceptable indicator of iron deficiency in haemodialysis patients.

scholarly journals Day-to-day variation in iron-status measures in young iron-deplete women

2005 ◽  
Vol 94 (4) ◽  
pp. 551-556 ◽  
Author(s):  
Anita Belza ◽  
Marianne Henriksen ◽  
Annette K Ersbøll ◽  
Shakuntala H Thilsted ◽  
Inge Tetens
Keyword(s):  
Menstrual Cycle ◽  
Observational Studies ◽  
Iron Status ◽  
Venous Blood ◽  
Blood Sampling ◽  
Volume Distribution ◽  
Distribution Width ◽  
Blood Samples ◽  
Significance Level ◽  
True Value

In intervention and observational studies, it is necessary to determine the number of blood samples required to estimate the true value of Fe-status measures. The aim of the present study was to determine the number of days for blood sampling required in order to measure the ‘true value’ of five Fe-status parameters in young Fe-depleted women and to investigate the effect of menstrual cycle on these measures. Twelve women (aged 23–30 years), non-anaemic but with low Fe stores, participated in the study. Venous blood samples were collected under standardised conditions on fifteen non-consecutive days during a 5-week period. All blood samples were analysed for Hb, serum ferritin (SF), serum transferrin receptors (sTfR), red blood cell volume distribution width (RDW) and reticulocytes (RET), and body Fe stores were calculated as the ratio between sTfR and SF. No systematic changes were found in the investigated parameters during the study. When analytical variations were accounted for, the day-to-day variations (CV%) were as follows: Hb 2·9 %, SF 8·2 %, RET 26·0 %, RDW 2·4 % and sTfR 8·1 %. Calculating the ‘true value’ with a 5 % significance level and 80 % power showed that one blood sample was sufficient for Hb, SF, sTfR and RDW, whereas seven blood-sampling days were needed for RET. In this study, no significant differences in Fe status were found across the menstrual cycle. The conclusions from this study are valid for studies conducted under similar strict conditions.

scholarly journals Análise do perfil hematológico e parasitológico de comunidades ribeirinhas da região amazônica

2021 ◽  
Vol 10 (3) ◽  
pp. e44710313560
Author(s):  
Gabriela Evelin Anjo Silva ◽  
Érica dos Santos Sarges ◽  
Larissa Nunes da Cruz ◽  
Cleidiane dos Santos Sarges ◽  
Marly de Fátima Carvalho de Melo ◽  
...  
Keyword(s):  
Volume Distribution ◽  
Distribution Width

Objetivo: Analisar a ocorrência e os determinantes de anemia e parasitose em moradores de comunidades fluviais da região amazônica. Métodos: Entre 2016 e 2017 foram coletadas amostras biológicas e dados socioeconômicos, alimentares e sanitários de 213 indivíduos residentes nas comunidades de Maracujá e Murucutum. Foram realizadas análises hematológicas da contagem total de eritrócitos, hemoglobina, hematócrito, VCM (Volume Corpuscular Médio), HCM (Hemoglobina Corpuscular Média), CHCM (Concentração da Hemoglobina Corpuscular Média), RDW (Redcell volume Distribution Width), leucócitos totais e plaquetas. Amostras de fezes foram analisadas para ivestigação de helmintos e protozoários. Resultados: Dos 213 sujeitos, apenas 4,70% (10) não apresentaram nenhuma das condições estudadas. Na análise hematológica, 22% (n=47) apresentaram anemia, com 23 do tipo microcítica e hipocrômica e 24 normocítica e normocrômica. Estavam infectados por por parasitas intestinais 93% (n=198) dos sujeitos estudados. Na análise da associação entre ocorrência de parasitose e anemia, 19,71% (42) indivíduos apresentaram ambas as condições. Conclusão: A alimentação baseada em açaí, carne bovina e de peixe proporciona à população estudada uma proteção contra anemias de origem alimentar, enquanto são altas as ocorrências de parasitoses e anemias associadas a estas devido às precárias condições de higiene e saneamento básico nessa população.

Hypothyroidism Leads to More Small-Sized Platelets in Circulation

1987 ◽  
Vol 58 (04) ◽  
pp. 964-965 ◽  
Author(s):  
J J van Doormaal ◽  
J van der Meer ◽  
H R Oosten ◽  
M R Halie ◽  
H Doorenbos
Keyword(s):  
Platelet Count ◽  
Cell Count ◽  
Mean Platelet Volume ◽  
Volume Distribution ◽  
Red Cell ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Red Cell Count

SummaryThe effect of induced hypothyroidism on platelet count and platelet volume distribution was studied in twelve athyreotic patients, After a two weeks withdrawal of triiodothyronine supplementation, platelet count and the ratio between platelet and red cell count were increased in all patients. Furthermore, mean platelet volume was declined and platelet distribution width was risen. Thus, hypothyroidism appears to increase the number of circulating platelets, especially the smaller ones.

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