scholarly journals DNA Major Groove Binding

2020 ◽  
Author(s):  
Keyword(s):  
Major Groove ◽  
Groove Binding

scholarly journals Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 8490-8494 ◽  
Author(s):  
Haiyang Gao ◽  
Zhi Zhu ◽  
Xiankai Jiang ◽  
Jun Guo ◽  
Bo Song ◽  
...  
Keyword(s):  
Major Groove ◽  
Groove Binding ◽  
Cadmium Ion

scholarly journals Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

2020 ◽  
Vol 16 ◽  
pp. 2201-2211
Author(s):  
Poulami Jana ◽  
Filip Šupljika ◽  
Carsten Schmuck ◽  
Ivo Piantanida
Keyword(s):  
Thermal Denaturation ◽  
Major Groove ◽  
Groove Binding ◽  
Dna Intercalator ◽  
Dna Minor Groove ◽  
Ph Values ◽  
Naphthalene Diimide ◽  
Threading Intercalation ◽  
Neutral Conditions ◽  
Pendant Arms

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading intercalation into ds-DNAs only at pH 5, while at neutral conditions (pH 7) NDI-GCP2 switched to the DNA minor groove binding. Intriguingly, NDI-GCP2 was at both pH values studied bound to the ds-RNA major groove, still showing a higher affinity and thermal denaturation effect at pH 5 due to GCP protonation. At excess over the DNA/RNA conjugate NDI-GCP2 showed also aggregation along the ds-polynucleotide and AFM and DLS demonstrated that NDI-GCP2 has pronounced ds-DNA condensation ability.

NMR Evidence for Major Groove Binding of BothΛ- andΔ-[Ru(bpy)2(pqx)](PF6)2 to the Oligonucleotide d(CGCGAATTCGCG)2

2004 ◽  
Vol 2004 (16) ◽  
pp. 3326-3334 ◽  
Author(s):  
Achilleas Garoufis ◽  
Gerasimos Malandrinos ◽  
Nick Hadjiliadis
Keyword(s):  
Major Groove ◽  
Groove Binding

Major groove binding of the tRNA/mRNA complex to the 16 S ribosomal RNA decoding site 1 1Edited by D. E. Draper

1999 ◽  
Vol 285 (5) ◽  
pp. 2069-2078 ◽  
Author(s):  
Margaret S VanLoock ◽  
Thomas R Easterwood ◽  
Stephen C Harvey
Keyword(s):  
Ribosomal Rna ◽  
Major Groove ◽  
Groove Binding

scholarly journals Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch

1998 ◽  
Vol 5 (3) ◽  
pp. 119-133 ◽  
Author(s):  
Ryan E. Bremer ◽  
Eldon E. Baird ◽  
Peter B. Dervan
Keyword(s):  
Binding Proteins ◽  
Major Groove ◽  
Groove Binding

Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding Ligands†

Biochemistry ◽  
2004 ◽  
Vol 43 (13) ◽  
pp. 3880-3890 ◽  
Author(s):  
Doan H. Nguyen-Hackley ◽  
Elizabeth Ramm ◽  
Christina M. Taylor ◽  
J. Keith Joung ◽  
Peter B. Dervan ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Major Groove ◽  
Groove Binding ◽  
Allosteric Inhibition

scholarly journals Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding

2017 ◽  
Vol 15 (21) ◽  
pp. 4522-4526 ◽  
Author(s):  
Milena Balazy ◽  
Alejandra Fausto ◽  
Christina Voskanian ◽  
Bianca Chavez ◽  
Harmanpreet Panesar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Major Groove ◽  
Groove Binding ◽  
Azinomycin B ◽  
Derivatives Of

Compound1d(Kapp= 2.4 × 107M−1), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding.

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