scholarly journals Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding

2017 ◽  
Vol 15 (21) ◽  
pp. 4522-4526 ◽  
Author(s):  
Milena Balazy ◽  
Alejandra Fausto ◽  
Christina Voskanian ◽  
Bianca Chavez ◽  
Harmanpreet Panesar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Major Groove ◽  
Groove Binding ◽  
Azinomycin B ◽  
Derivatives Of

Compound1d(Kapp= 2.4 × 107M−1), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding.

scholarly journals Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug—Design and Mechanism of Action

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4132
Author(s):  
Adam J. Buric ◽  
Jonathan Dickerhoff ◽  
Danzhou Yang
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Mechanism Of Action ◽  
Binding Mode ◽  
Mechanistic Study ◽  
Major Groove ◽  
Transcription Inhibition ◽  
Groove Binding ◽  
Targeted Agent ◽  
Anticancer Compound

This review is dedicated to Professor William A. Denny’s discovery of XR5944 (also known as MLN944). XR5944 is a DNA-targeted agent with exceptionally potent antitumor activity and a novel DNA binding mode, bis-intercalation and major groove binding, as well as a novel mechanism of action, transcription inhibition. This novel anticancer compound represents a remarkable accomplishment resulting from two decades of drug discovery by Professor Denny and coworkers. Here, we review our work on the structural study of the DNA binding mode of XR5944 and mechanistic study of XR5944 action.

Governing the DNA-binding mode of styryl dyes by the length of their alkyl substituents – from intercalation to major groove binding

2018 ◽  
Vol 16 (4) ◽  
pp. 545-554 ◽  
Author(s):  
Daria V. Berdnikova ◽  
Nikolai I. Sosnin ◽  
Olga A. Fedorova ◽  
Heiko Ihmels
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Major Groove ◽  
Groove Binding ◽  
Styryl Dyes

The length of alkyl substituents governs the DNA binding mode of mono- and bis-chromophoric styryl dyes.

scholarly journals Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 8490-8494 ◽  
Author(s):  
Haiyang Gao ◽  
Zhi Zhu ◽  
Xiankai Jiang ◽  
Jun Guo ◽  
Bo Song ◽  
...  
Keyword(s):  
Major Groove ◽  
Groove Binding ◽  
Cadmium Ion

Dicationic derivatives of dinaphthotetraaza[14]annulene: synthesis, crystal structures and the preliminary evaluation of their DNA binding properties

Tetrahedron ◽  
2015 ◽  
Vol 71 (24) ◽  
pp. 4163-4173 ◽  
Author(s):  
Alicja Kaźmierska ◽  
Marlena Gryl ◽  
Katarzyna Stadnicka ◽  
Lesław Sieroń ◽  
Andrzej Eilmes ◽  
...  
Keyword(s):  
Dna Binding ◽  
Crystal Structures ◽  
Preliminary Evaluation ◽  
Binding Properties ◽  
Dna Binding Properties ◽  
Derivatives Of

scholarly journals Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

2020 ◽  
Vol 16 ◽  
pp. 2201-2211
Author(s):  
Poulami Jana ◽  
Filip Šupljika ◽  
Carsten Schmuck ◽  
Ivo Piantanida
Keyword(s):  
Thermal Denaturation ◽  
Major Groove ◽  
Groove Binding ◽  
Dna Intercalator ◽  
Dna Minor Groove ◽  
Ph Values ◽  
Naphthalene Diimide ◽  
Threading Intercalation ◽  
Neutral Conditions ◽  
Pendant Arms

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading intercalation into ds-DNAs only at pH 5, while at neutral conditions (pH 7) NDI-GCP2 switched to the DNA minor groove binding. Intriguingly, NDI-GCP2 was at both pH values studied bound to the ds-RNA major groove, still showing a higher affinity and thermal denaturation effect at pH 5 due to GCP protonation. At excess over the DNA/RNA conjugate NDI-GCP2 showed also aggregation along the ds-polynucleotide and AFM and DLS demonstrated that NDI-GCP2 has pronounced ds-DNA condensation ability.

NMR Evidence for Major Groove Binding of BothΛ- andΔ-[Ru(bpy)2(pqx)](PF6)2 to the Oligonucleotide d(CGCGAATTCGCG)2

2004 ◽  
Vol 2004 (16) ◽  
pp. 3326-3334 ◽  
Author(s):  
Achilleas Garoufis ◽  
Gerasimos Malandrinos ◽  
Nick Hadjiliadis
Keyword(s):  
Major Groove ◽  
Groove Binding

Mechanism of DNA-binding of some aminoalkylamino-derivatives of anthraquinone and naphthacenequinone

1980 ◽  
Vol 32 (1) ◽  
pp. 78-80 ◽  
Author(s):  
T. W. PLUMBRIDGE ◽  
V. KNIGHT ◽  
K. L. PATEL ◽  
J. R. BROWN
Keyword(s):  
Dna Binding ◽  
Derivatives Of
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