DNA Major Groove Binding Agent

2020 ◽  
Author(s):  
Keyword(s):  
Major Groove ◽  
Binding Agent ◽  
Groove Binding

scholarly journals Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 8490-8494 ◽  
Author(s):  
Haiyang Gao ◽  
Zhi Zhu ◽  
Xiankai Jiang ◽  
Jun Guo ◽  
Bo Song ◽  
...  
Keyword(s):  
Major Groove ◽  
Groove Binding ◽  
Cadmium Ion

scholarly journals DNA Minor Groove Binding with Bisbenzamidine-Ru(II) Complexes

2019 ◽  
Author(s):  
Mateo I. Sánchez ◽  
Gustavo Rama ◽  
Renata Calo ◽  
Kübra Ucar ◽  
Per Lincoln ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Coordination Compounds ◽  
Photophysical Properties ◽  
Organic Ligand ◽  
Minor Groove ◽  
The Other ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)<sub>2</sub><b>b4bpy</b>]<sup>2+</sup>, <b>Δ‑4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

scholarly journals Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

2020 ◽  
Vol 16 ◽  
pp. 2201-2211
Author(s):  
Poulami Jana ◽  
Filip Šupljika ◽  
Carsten Schmuck ◽  
Ivo Piantanida
Keyword(s):  
Thermal Denaturation ◽  
Major Groove ◽  
Groove Binding ◽  
Dna Intercalator ◽  
Dna Minor Groove ◽  
Ph Values ◽  
Naphthalene Diimide ◽  
Threading Intercalation ◽  
Neutral Conditions ◽  
Pendant Arms

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading intercalation into ds-DNAs only at pH 5, while at neutral conditions (pH 7) NDI-GCP2 switched to the DNA minor groove binding. Intriguingly, NDI-GCP2 was at both pH values studied bound to the ds-RNA major groove, still showing a higher affinity and thermal denaturation effect at pH 5 due to GCP protonation. At excess over the DNA/RNA conjugate NDI-GCP2 showed also aggregation along the ds-polynucleotide and AFM and DLS demonstrated that NDI-GCP2 has pronounced ds-DNA condensation ability.

NMR Evidence for Major Groove Binding of BothΛ- andΔ-[Ru(bpy)2(pqx)](PF6)2 to the Oligonucleotide d(CGCGAATTCGCG)2

2004 ◽  
Vol 2004 (16) ◽  
pp. 3326-3334 ◽  
Author(s):  
Achilleas Garoufis ◽  
Gerasimos Malandrinos ◽  
Nick Hadjiliadis
Keyword(s):  
Major Groove ◽  
Groove Binding

Major groove binding of the tRNA/mRNA complex to the 16 S ribosomal RNA decoding site 1 1Edited by D. E. Draper

1999 ◽  
Vol 285 (5) ◽  
pp. 2069-2078 ◽  
Author(s):  
Margaret S VanLoock ◽  
Thomas R Easterwood ◽  
Stephen C Harvey
Keyword(s):  
Ribosomal Rna ◽  
Major Groove ◽  
Groove Binding

scholarly journals Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch

1998 ◽  
Vol 5 (3) ◽  
pp. 119-133 ◽  
Author(s):  
Ryan E. Bremer ◽  
Eldon E. Baird ◽  
Peter B. Dervan
Keyword(s):  
Binding Proteins ◽  
Major Groove ◽  
Groove Binding

Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding Ligands†

Biochemistry ◽  
2004 ◽  
Vol 43 (13) ◽  
pp. 3880-3890 ◽  
Author(s):  
Doan H. Nguyen-Hackley ◽  
Elizabeth Ramm ◽  
Christina M. Taylor ◽  
J. Keith Joung ◽  
Peter B. Dervan ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Major Groove ◽  
Groove Binding ◽  
Allosteric Inhibition
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