A Rare PSEN1 (Leu85Pro) Mutation Causing Alzheimer’s Disease in a 29-Year-Old Woman Presenting as Corticobasal Syndrome

2019 ◽  
Vol 70 (3) ◽  
pp. 655-658
Author(s):  
Sara López-García ◽  
Julio Jiménez-Bonilla ◽  
Anjana López Delgado ◽  
Pedro Orizaola Balaguer ◽  
Jon Infante Ceberio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

2019 ◽  
Vol 15 (9) ◽  
pp. 1218-1228 ◽  
Author(s):  
Nobutaka Sakae ◽  
Keith A. Josephs ◽  
Irene Litvan ◽  
Melissa E. Murray ◽  
Ranjan Duara ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

scholarly journals Degradation of emotion processing ability in corticobasal syndrome and Alzheimer’s disease

Brain ◽  
2014 ◽  
Vol 137 (11) ◽  
pp. 3061-3072 ◽  
Author(s):  
Fiona Kumfor ◽  
Laurie-Anne Sapey-Triomphe ◽  
Cristian E. Leyton ◽  
James R. Burrell ◽  
John R. Hodges ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Emotion Processing ◽  
Corticobasal Syndrome ◽  
Processing Ability

scholarly journals CORTICOBASAL SYNDROME DUE TO ALZHEIMER’S DISEASE

2021 ◽  
Author(s):  
Mariana Maciel Pinheiro ◽  
Victor Albuquerque ◽  
Pedro Albuquerque ◽  
Eduardo Maranhão ◽  
Jonathan Diniz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Brain Mri ◽  
Corticobasal Syndrome ◽  
Csf Biomarkers ◽  
College Level ◽  
Early Onset Dementia ◽  
Ideomotor Apraxia ◽  
Disease Modifying Agents

Background: Corticobasal Syndrome (CBS) is a neurodegenerative syndrome that combines cortical and cognitive deficits secondary to different underlying pathological entities. Objectives: to report an early onset dementia case fulfilling criteria of probable CBS due to Alzheimer’s Disease (AD) based on biomarkers and neuroimaging. Methods: case report. Results: a 57-yearsold woman with college-level education and 18 months of cognitive decline. The first symptom was progressive inability to change gears in her car, followed by difficulties to get dressed, cognitive and motor complaints. Neurological examination revealed marked limb bilateral ideomotor apraxia and mild asymetric parkinsonism. Cognitive tests showed mild visuospatial and language impairments, scoring 18/30 in the MoCA. Brain MRI and FDG PET showed bilateral posterior atrophy and hypometabolism worse to the left. CSF biomarkers revealed decreased amyloid and increased tau and p-tau levels, a pattern suggestive of CBS due to AD. Conclusions: this case illustrates recent evidence that suggests when AD presents as CBS (CBS-AD), limb apraxia and language impairment are more prevalent. CBS patients with underlying AD pathology and tauopathies correctly diagnosed in the future may benefit from symptomatic therapies and future disease-modifying agents.

Corticobasal syndrome with Alzheimer's disease pathology

2007 ◽  
Vol 24 (1) ◽  
pp. 152-153 ◽  
Author(s):  
Akiko Imamura ◽  
Zbigniew K. Wszolek ◽  
John A. Lucas ◽  
Dennis W. Dickson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

scholarly journals CSF Alzheimer's disease-like pattern in corticobasal syndrome: evidence for a distinct disorder

2011 ◽  
Vol 82 (8) ◽  
pp. 834-838 ◽  
Author(s):  
B. Borroni ◽  
E. Premi ◽  
C. Agosti ◽  
A. Alberici ◽  
C. Cerini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome

2019 ◽  
Vol 398 ◽  
pp. 142-147 ◽  
Author(s):  
Vasilios C. Constantinides ◽  
George P. Paraskevas ◽  
Efthymia Efthymiopoulou ◽  
Leonidas Stefanis ◽  
Elisabeth Kapaki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome ◽  
Imaging Characteristics

scholarly journals The corticobasal syndrome–Alzheimer’s disease conundrum

2011 ◽  
Vol 11 (11) ◽  
pp. 1569-1578 ◽  
Author(s):  
Anhar Hassan ◽  
Jennifer L Whitwell ◽  
Keith A Josephs
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

scholarly journals Phenotype differences between corticobasal syndrome and progressive supranuclear palsy with and without Alzheimer’s disease biomarkers

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Anna Vasilevskaya ◽  
Foad Taghdiri ◽  
Namita Multani ◽  
Cassandra Jessica Anor ◽  
Karen Misquitta ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Progressive Supranuclear Palsy ◽  
Corticobasal Syndrome ◽  
Disease Biomarkers
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