scholarly journals Degradation of emotion processing ability in corticobasal syndrome and Alzheimer’s disease

Brain ◽  
2014 ◽  
Vol 137 (11) ◽  
pp. 3061-3072 ◽  
Author(s):  
Fiona Kumfor ◽  
Laurie-Anne Sapey-Triomphe ◽  
Cristian E. Leyton ◽  
James R. Burrell ◽  
John R. Hodges ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Emotion Processing ◽  
Corticobasal Syndrome ◽  
Processing Ability

A Rare PSEN1 (Leu85Pro) Mutation Causing Alzheimer’s Disease in a 29-Year-Old Woman Presenting as Corticobasal Syndrome

2019 ◽  
Vol 70 (3) ◽  
pp. 655-658
Author(s):  
Sara López-García ◽  
Julio Jiménez-Bonilla ◽  
Anjana López Delgado ◽  
Pedro Orizaola Balaguer ◽  
Jon Infante Ceberio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

scholarly journals Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease

2020 ◽  
Vol 15 (6) ◽  
pp. 681-694
Author(s):  
Aurélie L Manuel ◽  
Daniel Roquet ◽  
Ramon Landin-Romero ◽  
Fiona Kumfor ◽  
Rebekah M Ahmed ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Decision Making ◽  
Frontotemporal Dementia ◽  
Delay Discounting ◽  
Animal Studies ◽  
Negative Emotion ◽  
Emotion Processing ◽  
Brain Regions ◽  
Behavioral Variant Frontotemporal Dementia

Abstract Negative and positive emotions are known to shape decision-making toward more or less impulsive responses, respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedial prefrontal cortex (vmPFC) and the amygdala. How these processes interact at the behavioral and brain levels is still unclear. We used a lesion model to address this question. Study participants included individuals diagnosed with behavioral-variant frontotemporal dementia (bvFTD, n = 18), who typically present deficits in decision-making/emotion processing and atrophy of the vmPFC, individuals with Alzheimer’s disease (AD, n = 12) who present with atrophy in limbic structures and age-matched healthy controls (CTRL, n = 15). Prior to each choice on the delay discounting task participants were cued with a positive, negative or neutral picture and asked to vividly imagine witnessing the event. As hypothesized, our findings showed that bvFTD patients were more impulsive than AD patients and CTRL and did not show any emotion-related modulation of delay discounting rate. In contrast, AD patients showed increased impulsivity when primed by negative emotion. This increased impulsivity was associated with reduced integrity of bilateral amygdala in AD but not in bvFTD. Altogether, our results indicate that decision-making and emotion interact at the level of the amygdala supporting findings from animal studies.

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

2019 ◽  
Vol 15 (9) ◽  
pp. 1218-1228 ◽  
Author(s):  
Nobutaka Sakae ◽  
Keith A. Josephs ◽  
Irene Litvan ◽  
Melissa E. Murray ◽  
Ranjan Duara ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Emotion processing in Alzheimer's disease

1997 ◽  
Vol 3 (5) ◽  
pp. 411-419 ◽  
Author(s):  
NICOLE L. CADIEUX ◽  
KEVIN W. GREVE
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Right Hemisphere ◽  
Emotion Processing ◽  
Processing System ◽  
Affective Stimuli ◽  
Task Instructions ◽  
Right Hemisphere Dysfunction ◽  
Processing Deficits

Emotion processing deficits may have an important effect on the quality of life of Alzheimer's disease (AD) patients and their families, yet there are few studies in this area and little is known about the cause of such deficits in AD. This study sought to determine if some AD patients have a disruption in a specific right hemisphere emotion processing system, and to determine if the processing of emotional facial expression is more vulnerable to the pathology of AD than is the perception of emotional prosody. It was specifically hypothesized that patients with greater right hemisphere dysfunction (low spatial AD patients) would be impaired on emotion processing tasks relative to those with predominantly left hemisphere dysfunction (low verbal AD patients). Both groups showed impairment on emotion processing tasks but for different reasons. The low verbal patients performed poorly on the affect processing measures because they had difficulty comprehending and/or remembering the task instructions. In contrast, low spatial AD patients have emotion processing deficits that are independent of language and/or memory and may be due to a more general visuoperceptual deficit that affects the perception of static but not dynamic affective stimuli. (JINS, 1997, 3, 411–419.)

scholarly journals CORTICOBASAL SYNDROME DUE TO ALZHEIMER’S DISEASE

2021 ◽  
Author(s):  
Mariana Maciel Pinheiro ◽  
Victor Albuquerque ◽  
Pedro Albuquerque ◽  
Eduardo Maranhão ◽  
Jonathan Diniz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Brain Mri ◽  
Corticobasal Syndrome ◽  
Csf Biomarkers ◽  
College Level ◽  
Early Onset Dementia ◽  
Ideomotor Apraxia ◽  
Disease Modifying Agents

Background: Corticobasal Syndrome (CBS) is a neurodegenerative syndrome that combines cortical and cognitive deficits secondary to different underlying pathological entities. Objectives: to report an early onset dementia case fulfilling criteria of probable CBS due to Alzheimer’s Disease (AD) based on biomarkers and neuroimaging. Methods: case report. Results: a 57-yearsold woman with college-level education and 18 months of cognitive decline. The first symptom was progressive inability to change gears in her car, followed by difficulties to get dressed, cognitive and motor complaints. Neurological examination revealed marked limb bilateral ideomotor apraxia and mild asymetric parkinsonism. Cognitive tests showed mild visuospatial and language impairments, scoring 18/30 in the MoCA. Brain MRI and FDG PET showed bilateral posterior atrophy and hypometabolism worse to the left. CSF biomarkers revealed decreased amyloid and increased tau and p-tau levels, a pattern suggestive of CBS due to AD. Conclusions: this case illustrates recent evidence that suggests when AD presents as CBS (CBS-AD), limb apraxia and language impairment are more prevalent. CBS patients with underlying AD pathology and tauopathies correctly diagnosed in the future may benefit from symptomatic therapies and future disease-modifying agents.

Corticobasal syndrome with Alzheimer's disease pathology

2007 ◽  
Vol 24 (1) ◽  
pp. 152-153 ◽  
Author(s):  
Akiko Imamura ◽  
Zbigniew K. Wszolek ◽  
John A. Lucas ◽  
Dennis W. Dickson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

MEMORY AND EMOTION PROCESSING IN HEALTHY SUBJECTS, FOCAL BRAIN-DAMAGED AND PATIENTS WITH ALZHEIMER'S DISEASE

2002 ◽  
Author(s):  
ANNA NEUGEBAUER ◽  
PASQUALE CALABRESE ◽  
KIRSTEN SCHMIEDER ◽  
ALBRECHT G. HARDERS ◽  
DOMENICO FERRI ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Subjects ◽  
Emotion Processing

scholarly journals CSF Alzheimer's disease-like pattern in corticobasal syndrome: evidence for a distinct disorder

2011 ◽  
Vol 82 (8) ◽  
pp. 834-838 ◽  
Author(s):  
B. Borroni ◽  
E. Premi ◽  
C. Agosti ◽  
A. Alberici ◽  
C. Cerini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome

2019 ◽  
Vol 398 ◽  
pp. 142-147 ◽  
Author(s):  
Vasilios C. Constantinides ◽  
George P. Paraskevas ◽  
Efthymia Efthymiopoulou ◽  
Leonidas Stefanis ◽  
Elisabeth Kapaki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome ◽  
Imaging Characteristics
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