scholarly journals Phenotype differences between corticobasal syndrome and progressive supranuclear palsy with and without Alzheimer’s disease biomarkers

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Anna Vasilevskaya ◽  
Foad Taghdiri ◽  
Namita Multani ◽  
Cassandra Jessica Anor ◽  
Karen Misquitta ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Progressive Supranuclear Palsy ◽  
Corticobasal Syndrome ◽  
Disease Biomarkers

scholarly journals Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tamara G. Fong ◽  
Sarinnapha M. Vasunilashorn ◽  
Yun Gou ◽  
Towia A. Libermann ◽  
Simon Dillon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Postoperative Delirium ◽  
Disease Biomarkers

scholarly journals Correlation between oligomerizaton of amyloid beta in plasma and other Alzheimer's disease biomarkers

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S91
Author(s):  
Sungmin Kang ◽  
Jeewon Suh ◽  
Jeong Min Pyun ◽  
Young Chul Youn ◽  
Ji Sun Yu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Disease Biomarkers

scholarly journals Pre‐analytical protocol for measuring Alzheimer's disease biomarkers in fresh CSF

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Oskar Hansson ◽  
Sandra Rutz ◽  
Henrik Zetterberg ◽  
Ekaterina Bauer ◽  
Teresa Hähl ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Biomarkers ◽  
Analytical Protocol

Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease

1999 ◽  
Vol 46 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Christopher B. Chambers ◽  
John M. Lee ◽  
Juan C. Troncoso ◽  
Stephen Reich ◽  
Nancy A. Muma
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Progressive Supranuclear Palsy ◽  
Mrna Isoforms

Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer’s Disease Biomarkers

2021 ◽  
pp. 1-13
Author(s):  
Sung Hoon Kang ◽  
Hanna Cho ◽  
Jiho Shin ◽  
Hang-Rai Kim ◽  
Young Noh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Amyloid Β ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Clinical Feature ◽  
Progressive Aphasia ◽  
Disease Biomarkers ◽  
Primary Progressive

Background: Primary progressive aphasia (PPA) is associated with amyloid-β (Aβ) pathology. However, clinical feature of PPA based on Aβ positivity remains unclear. Objective: We aimed to assess the prevalence of Aβ positivity in patients with PPA and compare the clinical characteristics of patients with Aβ-positive (A+) and Aβ-negative (A–) PPA. Further, we applied Aβ and tau classification system (AT system) in patients with PPA for whom additional information of in vivo tau biomarker was available. Methods: We recruited 110 patients with PPA (41 semantic [svPPA], 27 non-fluent [nfvPPA], 32 logopenic [lvPPA], and 10 unclassified [ucPPA]) who underwent Aβ-PET imaging at multi centers. The extent of language impairment and cortical atrophy were compared between the A+ and A–PPA subgroups using general linear models. Results: The prevalence of Aβ positivity was highest in patients with lvPPA (81.3%), followed by ucPPA (60.0%), nfvPPA (18.5%), and svPPA (9.8%). The A+ PPA subgroup manifested cortical atrophy mainly in the left superior temporal/inferior parietal regions and had lower repetition scores compared to the A–PPA subgroup. Further, we observed that more than 90%(13/14) of the patients with A+ PPA had tau deposition. Conclusion: Our findings will help clinicians understand the patterns of language impairment and cortical atrophy in patients with PPA based on Aβ deposition. Considering that most of the A+ PPA patents are tau positive, understanding the influence of Alzheimer’s disease biomarkers on PPA might provide an opportunity for these patients to participate in clinical trials aimed for treating atypical Alzheimer’s disease.

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