An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP ‐43 proteinopathy, associated with Alzheimer's disease pathology

2021 ◽  
Author(s):  
So Tando ◽  
Takashi Kasai ◽  
Ikuko Mizuta ◽  
Hisashi Takahashi ◽  
Takeshi Yaoi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Motor Cortex ◽  
Substantia Nigra ◽  
Corticobasal Syndrome ◽  
Autopsy Case

scholarly journals An autopsy case of Alzheimer’s disease presenting with corticobasal syndrome

2013 ◽  
Vol 53 (10) ◽  
pp. 814-820 ◽  
Author(s):  
Naoki Fujii ◽  
Tomihiro Wakamiya ◽  
Akihiro Watanabe ◽  
Hirokazu Furuya ◽  
Kensuke Sasaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome ◽  
Autopsy Case

Coexistence of paired helical filaments and polyglucosan bodies in the same neuron in an autopsy case of Alzheimer's disease

1996 ◽  
Vol 92 (5) ◽  
pp. 511-514 ◽  
Author(s):  
M. Inoue ◽  
Saburo Yagishita ◽  
Yoji Itoh ◽  
Naoji Amano ◽  
Masaaki Matsushita
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Paired Helical Filaments ◽  
Autopsy Case ◽  
Polyglucosan Bodies

scholarly journals Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 22 (22) ◽  
pp. 12256
Author(s):  
Estibaliz González de San Román ◽  
Alberto Llorente-Ovejero ◽  
Jonatan Martínez-Gardeazabal ◽  
Marta Moreno-Rodríguez ◽  
Lydia Giménez-Llort ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acid ◽  
Motor Cortex ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Neurodegenerative Disorder ◽  
Transgenic Mouse Model ◽  
Lipid Species ◽  
Triple Transgenic Mouse

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations. Recently, the regulation of neurolipid-mediated signaling and cerebral lipid species was shown in AD patients. The triple transgenic mouse model (3xTg-AD), harboring βAPPSwe, PS1M146V, and tauP301L transgenes, mimics many critical aspects of AD neuropathology and progressively develops neuropathological markers. Thus, in the present study, 3xTg-AD mice have been used to test the involvement of the neurolipid-based signaling by endocannabinoids (eCB), lysophosphatidic acid (LPA), and sphingosine 1-phosphate (S1P) in relation to the lipid deregulation. [35S]GTPγS autoradiography was used in the presence of specific agonists WIN55,212-2, LPA and CYM5442, to measure the activity mediated by CB1, LPA1, and S1P1 Gi/0 coupled receptors, respectively. Consecutive slides were used to analyze the relative intensities of multiple lipid species by MALDI Mass spectrometry imaging (MSI) with microscopic anatomical resolution. The quantitative analysis of the astrocyte population was performed by immunohistochemistry. CB1 receptor activity was decreased in the amygdala and motor cortex of 3xTg-AD mice, but LPA1 activity was increased in the corpus callosum, motor cortex, hippocampal CA1 area, and striatum. Conversely, S1P1 activity was reduced in hippocampal areas. Moreover, the observed modifications on PC, PA, SM, and PI intensities in different brain areas depend on their fatty acid composition, including decrease of polyunsaturated fatty acid (PUFA) phospholipids and increase of species containing saturated fatty acids (SFA). The regulation of some lipid species in specific brain regions together with the modulation of the eCB, LPA, and S1P signaling in 3xTg-AD mice indicate a neuroprotective adaptation to improve neurotransmission, relieve the myelination dysfunction, and to attenuate astrocyte-mediated neuroinflammation. These results could contribute to identify new therapeutic strategies based on the regulation of the lipid signaling in familial AD patients.

P8.19 Sensory-motor cortex reorganization in Alzheimer's disease: an MEG study

2011 ◽  
Vol 122 ◽  
pp. S100
Author(s):  
C. Salustri ◽  
F. Tecchio ◽  
F. Zappasodi ◽  
L. Tomasevic ◽  
M. Ercolani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Motor Cortex ◽  
Sensory Motor

A Rare PSEN1 (Leu85Pro) Mutation Causing Alzheimer’s Disease in a 29-Year-Old Woman Presenting as Corticobasal Syndrome

2019 ◽  
Vol 70 (3) ◽  
pp. 655-658
Author(s):  
Sara López-García ◽  
Julio Jiménez-Bonilla ◽  
Anjana López Delgado ◽  
Pedro Orizaola Balaguer ◽  
Jon Infante Ceberio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

2019 ◽  
Vol 15 (9) ◽  
pp. 1218-1228 ◽  
Author(s):  
Nobutaka Sakae ◽  
Keith A. Josephs ◽  
Irene Litvan ◽  
Melissa E. Murray ◽  
Ranjan Duara ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Corticobasal Syndrome

Tau Accumulation in Primary Motor Cortex of Variant Alzheimer’s Disease with Spastic Paraparesis

2016 ◽  
Vol 51 (3) ◽  
pp. 671-675 ◽  
Author(s):  
Chul Hyoung Lyoo ◽  
Hanna Cho ◽  
Jae Yong Choi ◽  
Mi Song Hwang ◽  
Sang Kyoon Hong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Spastic Paraparesis
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