scholarly journals Sytnhesis of Organoboron Amide-Ester Branched Derivatives of Poly(Itaconic Anhydride-alt-2-Vinyl-1,3-Dioxolane) and Cancer Cells Interaction Studies

2019 ◽  
Author(s):  
Gülten Özçayan
Keyword(s):  
Cancer Cells ◽  
Itaconic Anhydride ◽  
Interaction Studies ◽  
Derivatives Of

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

scholarly journals Activation ofp16Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2′-Deoxyzebularine

2008 ◽  
Vol 51 (23) ◽  
pp. 7593-7601 ◽  
Author(s):  
Christine B. Yoo ◽  
Rocco Valente ◽  
Costantino Congiatu ◽  
Federica Gavazza ◽  
Annette Angel ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Derivatives Of

Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

2018 ◽  
Vol 47 (13) ◽  
pp. 4467-4477 ◽  
Author(s):  
Lucinda K. Batchelor ◽  
Beatrice Berti ◽  
Cristiana Cesari ◽  
Iacopo Ciabatti ◽  
Paul J. Dyson ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Molecular Structures ◽  
Water Soluble ◽  
Human Cancer Cells ◽  
Derivatives Of

The cytotoxicity towards human cancer cells of water soluble Chini clusters is reported.

Ester derivatives of salinomycin efficiently eliminate breast cancer cells via ER-stress-induced apoptosis

2021 ◽  
Vol 893 ◽  
pp. 173824
Author(s):  
Dominika Kuran ◽  
Sylwia Flis ◽  
Michał Antoszczak ◽  
Marlena Piskorek ◽  
Adam Huczyński
Keyword(s):  
Breast Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Induced Apoptosis ◽  
Derivatives Of

scholarly journals Chemoenzymatic Synthesis and Some Biological Properties of O-phosphoryl Derivatives of (E)-resveratrol

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Danilo Aleo ◽  
Venera Cardile ◽  
Rosa Chillemi ◽  
Giuseppe Granata ◽  
Sebastiano Sciuto
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Binding Affinity ◽  
Spectroscopic Investigation ◽  
Biological Properties ◽  
Chemoenzymatic Synthesis ◽  
Prostate Cancer Cells ◽  
Phosphoramidite Chemistry ◽  
Protective Groups ◽  
Derivatives Of

3- O-, 3,5-di- O- and 4′- O-phosphoryl derivatives of ( E)-resveratrol have been obtained following a chemoenzymatic strategy. Variedly acylated resveratrol derivatives have been obtained first by exploiting regioselective properties of Pseudomonas cepacea or Candida antarctica lipases in organic solvents. Each acyl-resveratrol was then phosphorylated by the phosphoramidite chemistry protocol and in sequence freed of protective groups, affording the desired O-phosphoryl derivative. Following UV-absorption spectroscopic investigation on the interaction of the newly synthesized compounds with DNA, 4′- O-phosphorylresveratrol exhibited the best binding affinity. As a result of cytotoxicity tests, 3- O-phosphorylresveratrol was more active than resveratrol against DU 145 prostate cancer cells.

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