scholarly journals Activation ofp16Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2′-Deoxyzebularine

2008 ◽  
Vol 51 (23) ◽  
pp. 7593-7601 ◽  
Author(s):  
Christine B. Yoo ◽  
Rocco Valente ◽  
Costantino Congiatu ◽  
Federica Gavazza ◽  
Annette Angel ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Derivatives Of

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

scholarly journals δ EF1 associates with DNMT1 and maintains DNA methylation of the E‐cadherin promoter in breast cancer cells

2014 ◽  
Vol 4 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Akihiko Fukagawa ◽  
Hiroki Ishii ◽  
Keiji Miyazawa ◽  
Masao Saitoh
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
E Cadherin

scholarly journals Combined analysis of DNA methylation and cell cycle in cancer cells

Epigenetics ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Cécile Desjobert ◽  
Mounir El Maï ◽  
Tom Gérard-Hirne ◽  
Dominique Guianvarc'h ◽  
Arnaud Carrier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Combined Analysis

scholarly journals Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns

2012 ◽  
Vol 34 (2) ◽  
pp. 248-256 ◽  
Author(s):  
C. L. Doig ◽  
P. K. Singh ◽  
V. K. Dhiman ◽  
J. L. Thorne ◽  
S. Battaglia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Target Genes ◽  
Prostate Cancer Cells ◽  
Methylation Patterns

scholarly journals Global and gene specific DNA methylation in breast cancer cells was not affected during epithelial-to-mesenchymal transition in vitro

Neoplasma ◽  
2016 ◽  
Vol 63 (06) ◽  
pp. 901-910 ◽  
Author(s):  
B. SMOLKOVA ◽  
S. MIKLIKOVA ◽  
V. HORVATHOVA KAJABOVA ◽  
A. BABELOVA ◽  
N. EL YAMANI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells

2012 ◽  
Vol 13 (7) ◽  
pp. 8259-8272 ◽  
Author(s):  
Sumiyo Morita ◽  
Ryou-u Takahashi ◽  
Riu Yamashita ◽  
Atsushi Toyoda ◽  
Takuro Horii ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Genome Wide Analysis ◽  
Genome Wide

Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

2018 ◽  
Vol 47 (13) ◽  
pp. 4467-4477 ◽  
Author(s):  
Lucinda K. Batchelor ◽  
Beatrice Berti ◽  
Cristiana Cesari ◽  
Iacopo Ciabatti ◽  
Paul J. Dyson ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Molecular Structures ◽  
Water Soluble ◽  
Human Cancer Cells ◽  
Derivatives Of

The cytotoxicity towards human cancer cells of water soluble Chini clusters is reported.

Ester derivatives of salinomycin efficiently eliminate breast cancer cells via ER-stress-induced apoptosis

2021 ◽  
Vol 893 ◽  
pp. 173824
Author(s):  
Dominika Kuran ◽  
Sylwia Flis ◽  
Michał Antoszczak ◽  
Marlena Piskorek ◽  
Adam Huczyński
Keyword(s):  
Breast Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Induced Apoptosis ◽  
Derivatives Of

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

Gut ◽  
2019 ◽  
Vol 69 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Masahiro Maeda ◽  
Hideyuki Takeshima ◽  
Naoko Iida ◽  
Naoko Hattori ◽  
Satoshi Yamashita ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cell ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Stem Cell Niche ◽  
Therapeutic Targets ◽  
Prognostic Impact ◽  
Cell Growth And Migration ◽  
Cell Niche

ObjectiveCancer-associated fibroblasts (CAFs), a major component of cancer stroma, can confer aggressive properties to cancer cells by secreting multiple factors. Their phenotypes are stably maintained, but the mechanisms are not fully understood. We aimed to show the critical role of epigenetic changes in CAFs in maintaining their tumour-promoting capacity and to show the validity of the epigenomic approach in identifying therapeutic targets from CAFs to starve cancer cells.DesignTwelve pairs of primary gastric CAFs and their corresponding non-CAFs (NCAFs) were established from surgical specimens. Genome-wide DNA methylation and H3K27me3 analyses were conducted by BeadArray 450K and ChIP-on-Chip, respectively. Functions of potential a therapeutic target were analysed by inhibiting it, and prognostic impact was assessed in a database.ResultsCAFs had diverse and distinct DNA methylation and H3K27me3 patterns compared with NCAFs. Loss of H3K27me3, but not DNA methylation, in CAFs was enriched for genes involved in stem cell niche, cell growth, tissue development and stromal–epithelial interactions, such asWNT5A,GREM1,NOGandIGF2. Among these, we revealed that WNT5A, which had been considered to be derived from cancer cells, was highly expressed in cancer stromal fibroblasts, and was associated with poor prognosis. Inhibition of secreted WNT5A from CAFs suppressed cancer cell growth and migration.ConclusionsH3K27me3 plays a crucial role in defining tumour-promoting capacities of CAFs, and multiple stem cell niche factors were secreted from CAFs due to loss of H3K27me3. The validity of the epigenetic approach to uncover therapeutic targets for cancer-starving therapy was demonstrated.

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