Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

2018 ◽  
Vol 47 (13) ◽  
pp. 4467-4477 ◽  
Author(s):  
Lucinda K. Batchelor ◽  
Beatrice Berti ◽  
Cristiana Cesari ◽  
Iacopo Ciabatti ◽  
Paul J. Dyson ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Molecular Structures ◽  
Water Soluble ◽  
Human Cancer Cells ◽  
Derivatives Of

The cytotoxicity towards human cancer cells of water soluble Chini clusters is reported.

Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells

2006 ◽  
Vol 49 (13) ◽  
pp. 3800-3808 ◽  
Author(s):  
Vivek Barve ◽  
Fakhara Ahmed ◽  
Shreelekha Adsule ◽  
Sanjeev Banerjee ◽  
Sudhir Kulkarni ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Synthetic Derivatives ◽  
Derivatives Of

Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin

2013 ◽  
Vol 64 ◽  
pp. 621-628 ◽  
Author(s):  
Jian-Fei Liu ◽  
Chun-Yan Sang ◽  
Xiao-Hui Xu ◽  
Lin-Lin Zhang ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Derivatives Of

Synthesis and evaluation of apoptotic induction of human cancer cells by ester derivatives of thujone

2019 ◽  
Vol 29 (2) ◽  
pp. 268-280
Author(s):  
Emily Castner ◽  
Matthew Dickson ◽  
Anna Mykytyn ◽  
Navindra P. Seeram ◽  
Geneive E. Henry ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Derivatives Of ◽  
Apoptotic Induction

scholarly journals Synthesis and anticancer activity of 5-sulfonyl derivatives of 1,3-oxazole-4-carboxylates

2020 ◽  
Vol 15 (2) ◽  
pp. 13-21
Author(s):  
Stepan Pilyo ◽  
Оlexandr Kozachenko ◽  
Victor Zhirnov ◽  
Maryna Kachaeva ◽  
Oleksandr Kobzar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Complex Formation ◽  
Cancer Cells ◽  
Cell Lines ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Screening Protocol ◽  
Derivatives Of

A series of new 2-aryl 5-sulfonyl-1,3-oxazole-4-carboxylates for NCI anticancer screening protocol against 60 cancer cell lines were synthesized. Screening was performed in vitro on 60 cell lines of lungs, kidneys, CNS, ovaries, prostate, and breast cancer, leukemia, and melanoma. Methyl 5-benzylsulfonyl-2-phenyl-1,3-oxazole-4-carboxylate 15 exhibited potent and broad range of cytotoxic activity against tested human cancer cells with average GI50, TGI, and LC50 values of 5.37·10-6, 1.29·10-5 and 3.6·10-5 mol/L respectively. Molecular docking was used to evaluate the possible interaction of compound 15 with tubulin as well as a complex formation with CDK2.

A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells

2020 ◽  
Vol 30 (6) ◽  
pp. 750-752
Author(s):  
Sergey A. Gorbatov ◽  
Denis Yu. Uvarov ◽  
Alexander M. Scherbakov ◽  
Igor V. Zavarzin ◽  
Yulia A. Volkova ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Human Cancer ◽  
Water Soluble ◽  
Human Cancer Cells

Synthesis of New Calixarene Derivatives and Evaluation of Their Cytotoxic Activity

2021 ◽  
Author(s):  
Mehmet Oguz ◽  
Ayse Yildirim ◽  
Irem Mukaddes Durmus ◽  
Serdar Karakurt ◽  
Mustafa Yilmaz
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Carcinoma Cells ◽  
Spectroscopic Techniques ◽  
Dependent Manner ◽  
Human Cancer Cells ◽  
H Nmr ◽  
Cancerous Cells ◽  
Dose Dependent ◽  
Derivatives Of

Abstract Since calixarenes are more easily synthesized and functionalized than other supramolecules, they are compounds of interest in organic chemistry. In this study, the dihydrazide (3a and 3b) and diamino propyl (6a and 6b) derivatives of p-tert-butylcalix[4]arene and calix[4]arene were synthesized. Then the L-proline methyl ester substituted chlorocyclopropenium was reacted with the calix[4]arene derivatives (3a, 3b, 6a, and 6b) at room temperature in CH2Cl2 to obtain calix[4]arene superbase derivatives (4a, 4b, 7a, and 7b) in 75%, 60%, 70% and 55% yield, respectively. The synthesized compounds' structure was elucidated by using spectroscopic techniques (FTIR, 1H NMR, and 13C NMR ). The cytotoxic properties of the calix[4]arene superbase derivatives were investigated against different human cancerous cells, including A549, DLD-1, HEPG2, and PC-3, as well as human healthy epithelium cell line PNT1A. The cytotoxicity results showed that calix[4]arene superbase derivatives inhibited the proliferation of DLD-1, A549, HEPG2, and PC-3 cells in a dose-dependent manner. Compound 7a had the highest toxic effect on colorectal carcinoma (IC50: 4.7 µM), and the IC50 values were 18.5 µM and 74.4µM against human prostate and lung cancer cells, respectively. Furthermore, the compound 4b was found more effective on hepatocellular carcinoma cells (IC50: 210.2 µM). As a result, the synthesized calix[4]arene superbase derivatives can be developed to treat different human cancer cells. They can be considered as a preliminary result for molecular-level research.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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