An improved procedure for calculating the aerothermodynamic properties of a vitiated air test medium

Author(s):  
E. POWELL
Keyword(s):  
1973 ◽  
Vol 95 (2) ◽  
pp. 250-256 ◽  
Author(s):  
T. E. Cooper ◽  
J. P. Groff

This paper discusses the use of heat for producing clinical lesions in tissue and presents the design and analysis of a resistively heated surgical probe. The probe surface temperature is accurately maintained and controlled by using a Wheatstone bridge. The probe was embedded in a clear agar–water test medium, and the temperature field generated by the probe was measured with liquid crystals, a material that provides a visual display of certain isotherms. Experimental results compare within approximately 10 percent of a two-dimensional numerical solution. A one-dimensional theoretical model is also developed which examines the influence of blood flow on the temperature field.


1971 ◽  
Vol 104 (5) ◽  
pp. 486 ◽  
Author(s):  
Stanley A. Rosenthal
Keyword(s):  

2004 ◽  
Vol 182 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Z Cheng ◽  
M Elmes ◽  
SE Kirkup ◽  
DR Abayasekara ◽  
DC Wathes

We investigated the effect of n-6 polyunsaturated fatty acids (PUFAs) on prostaglandin (PG) production by the uterus. A mixed population of endometrial cells (epthelium and stroma) from late-gestation ewes were cultured in defined medium containing linoleic acid (LA, 18:2, n-6), gamma-linolenic acid (GLA, 18:3, n-6) or arachidonic acid (AA, 20:4, n-6) in concentrations of 0 (control), 20 or 100 microM. After 45 h in test medium with or without added PUFAs, cells were challenged with control medium (CM), oxytocin (OT, 250 nM), lipopolysaccharide (LPS, 0.1 micro g/ml) or dexamethasone (DEX, 5 microM) for 22 h in the continued presence of the same concentration of PUFA and the medium was collected for measurement of PGF(2alpha) and PGE(2). Supplementation with LA inhibited the production of PGF(2alpha) but did not alter PGE(2), whereas GLA and AA increased production of both PGs. All PUFA supplements thus increased the ratio of PGE(2) to PGF(2alpha) (E:F ratio) two- to threefold. In control cells, OT and LPS challenges stimulated the production of PGF(2alpha) and PGE(2). In all challenge groups, the concentrations of PGF(2alpha) in response to PUFAs followed the same pattern - LA<control<;GLA<AA - but there were significant alterations in responsiveness as a result of PUFA treatment. In the cells supplemented with 100 microM AA, there was no further increase in PGF(2alpha) output in the presence of OT or LPS and when 100 microM GLA was present neither LPS nor OT stimulated PGE(2) significantly. When LPS was given to AA-supplemented cells, the E:F ratio was increased. DEX did not change PGE(2) production in control or LA-treated cells, but the cells produced significantly less PGF(2alpha), so the E:F ratio was increased. In contrast, in GLA- and AA-treated cells, DEX reduced the production of both PGF(2alpha) and PGE(2), so the E:F ratio was unaltered. In summary, the study showed altered production of PGs in the presence of different PUFAs according to their position in the n-6 metabolic pathway. The type of PUFA present affected responsiveness to OT, LPS and DEX and also changed the ratio of PGE(2) to PGF(2alpha) produced. The possible implications of this work are discussed in relation to the effect of diet on term and pre-term labour, which both require upregulation of the endometrial PG synthetic pathway.


1939 ◽  
Vol 37 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Carolyn R. Falk ◽  
Helen Bieniasz Bucca ◽  
Margaret P. Simmons

1991 ◽  
Vol 27 (3) ◽  
pp. 390-392 ◽  
Author(s):  
R. N. JONES ◽  
J. A. WASHINGTON ◽  
M. A. PFALLER ◽  
F. P. KOONTZ ◽  
E. H. GERLACH ◽  
...  

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