scholarly journals How to predict the potential effect of chemicals on human health: an extended question of environmental toxicology

2006 ◽  
Author(s):  
A. Mueller ◽  
C. Graebsch ◽  
G. Wichmann ◽  
M. Bauer ◽  
O. Herbarth
Keyword(s):  
Human Health ◽  
Potential Effect ◽  
Environmental Toxicology

Polymorphism of bovine beta-casein and its potential effect on human health

2007 ◽  
Vol 48 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Stanisław Kamiński ◽  
Anna Cieślińska ◽  
Elżbieta Kostyra
Keyword(s):  
Human Health ◽  
Potential Effect ◽  
Beta Casein

scholarly journals Environmental toxicology and associated human health risks

2020 ◽  
Vol 27 (32) ◽  
pp. 39671-39675 ◽  
Author(s):  
Muhammad Shahid ◽  
Muhammad Nadeem ◽  
Hafiz Faiq Bakhat
Keyword(s):  
Human Health ◽  
Health Risks ◽  
Environmental Toxicology ◽  
Human Health Risks

scholarly journals The impact of natural disasters on the spread of COVID-19: a geospatial, agent-based epidemiology model

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Maximillian Van Wyk de Vries ◽  
Lekaashree Rambabu
Keyword(s):  
Infectious Diseases ◽  
Natural Disasters ◽  
Human Health ◽  
Natural Disaster ◽  
Potential Effect ◽  
Agent Based ◽  
Median Increase ◽  
Global Pandemic ◽  
Disaster Scenario ◽  
The Impact

Abstract Background Natural disasters and infectious diseases result in widespread disruption to human health and livelihood. At the scale of a global pandemic, the co-occurrence of natural disasters is inevitable. However, the impact of natural disasters on the spread of COVID-19 has not been extensively evaluated through epidemiological modelling. Methods We create an agent-based epidemiology model based on COVID-19 clinical, epidemiological, and geographic data. We first model 35 scenarios with varying natural disaster timing and duration for a COVID-19 outbreak in a theoretical region. We then evaluate the potential effect of an eruption of Vesuvius volcano on the spread of COVID-19 in Campania, Italy. Results In a majority of cases, the occurrence of a natural disaster increases the number of disease related fatalities. For a natural disaster fifty days after infection onset, the median increase in fatalities is 2, 59, and 180% for a 2, 14, and 31-day long natural disaster respectively, when compared to the no natural disaster scenario. For the Campania case, the median increase in fatalities is 1.1 and 2.4 additional fatalities per 100,000 for eruptions on day 1 and 100 respectively, and 60.0 additional fatalities per 100,000 for an eruption close to the peak in infections (day 50). Conclusion Our results show that the occurrence of a natural disaster in most cases leads to an increase in infection related fatalities, with wide variance in possible outcomes depending on the timing of the natural disaster relative to the peak in infections and the duration of the natural disaster.

Avian Models for Toxicity Testing

1984 ◽  
Vol 3 (6) ◽  
pp. 357-376 ◽  
Author(s):  
E. F. Hill ◽  
D. J. Hoffman
Keyword(s):  
Environmental Pollution ◽  
Human Health ◽  
Health Effects ◽  
Environmental Quality ◽  
Toxicity Testing ◽  
Environmental Toxicology ◽  
Test Models ◽  
Wildlife Toxicology

The use of birds as test models in experimental and environmental toxicology as related to health effects is reviewed, and an overview of descriptive tests routinely used in wildlife toxicology is provided. Toxicologic research on birds may be applicable to human health both directly by their use as models for mechanistic and descriptive studies and indirectly as monitors of environmental quality. Topics include the use of birds as models for study of teratogenesis and embryotoxicity, neurotoxicity, behavior, trends of environmental pollution, and for use in predictive wildlife toxicology. Uses of domestic and wild-captured birds are discussed.

scholarly journals The landscape of micro-inversions provides clues for population genetic analysis of humans

2020 ◽  
Author(s):  
Li Qu ◽  
Luotong Wang ◽  
Feifei He ◽  
Yilun Han ◽  
Longshu Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Nonhuman Primate ◽  
Nonhuman Primates ◽  
Genetic Diseases ◽  
Potential Effect ◽  
Human Migration ◽  
Human Populations ◽  
Population Genetic Analysis ◽  
Phylogenetic Structure ◽  
Migration History

AbstractBackgroundVariations in the human genome have been studied extensively. However, little is known about the role of micro-inversions (MIs), generally defined as small (<100 bp) inversions, in human evolution, diversity, and health. Depicting the pattern of MIs among diverse populations is critical for interpreting human evolutionary history and obtaining insight into genetic diseases.ResultsIn this paper, we explored the distribution of MIs in genomes from 26 human populations and 7 nonhuman primate genomes and analyzed the phylogenetic structure of the 26 human populations based on the MIs. We further investigated the functions of the MIs located within genes associated with human health. With hg19 as the reference genome, we detected 6,968 MIs among the 1,937 human samples and 24,476 MIs among the 7 nonhuman primate genomes. The analyses of MIs in human genomes showed that the MIs were rarely located in exonic regions. Nonhuman primates and human populations shared only 82 inverted alleles, and Africans had the most inverted alleles in common with nonhuman primates, which was consistent with the “Out of Africa” hypothesis. The clustering of MIs among the human populations also coincided with human migration history and ancestral lineages.ConclusionsWe propose that MIs are potential evolutionary markers for investigating population dynamics. Our results revealed the diversity of MIs in human populations and showed that they are essential to constructing human population relationships and have a potential effect on human health.

scholarly journals Natural products as mediators of disease

2017 ◽  
Vol 34 (2) ◽  
pp. 194-219 ◽  
Author(s):  
Neha Garg ◽  
Tal Luzzatto-Knaan ◽  
Alexey V. Melnik ◽  
Andrés Mauricio Caraballo-Rodríguez ◽  
Dimitrios J. Floros ◽  
...  
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Human Health ◽  
Potential Effect ◽  
Specialized Metabolites ◽  
Natural Product Research

The potential effect of microbiome-derived specialized metabolites on human health provides new and exciting avenues for natural product research.

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