Polymorphism of bovine beta-casein and its potential effect on human health

2007 ◽  
Vol 48 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Stanisław Kamiński ◽  
Anna Cieślińska ◽  
Elżbieta Kostyra
Keyword(s):  
Human Health ◽  
Potential Effect ◽  
Beta Casein

scholarly journals The impact of natural disasters on the spread of COVID-19: a geospatial, agent-based epidemiology model

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Maximillian Van Wyk de Vries ◽  
Lekaashree Rambabu
Keyword(s):  
Infectious Diseases ◽  
Natural Disasters ◽  
Human Health ◽  
Natural Disaster ◽  
Potential Effect ◽  
Agent Based ◽  
Median Increase ◽  
Global Pandemic ◽  
Disaster Scenario ◽  
The Impact

Abstract Background Natural disasters and infectious diseases result in widespread disruption to human health and livelihood. At the scale of a global pandemic, the co-occurrence of natural disasters is inevitable. However, the impact of natural disasters on the spread of COVID-19 has not been extensively evaluated through epidemiological modelling. Methods We create an agent-based epidemiology model based on COVID-19 clinical, epidemiological, and geographic data. We first model 35 scenarios with varying natural disaster timing and duration for a COVID-19 outbreak in a theoretical region. We then evaluate the potential effect of an eruption of Vesuvius volcano on the spread of COVID-19 in Campania, Italy. Results In a majority of cases, the occurrence of a natural disaster increases the number of disease related fatalities. For a natural disaster fifty days after infection onset, the median increase in fatalities is 2, 59, and 180% for a 2, 14, and 31-day long natural disaster respectively, when compared to the no natural disaster scenario. For the Campania case, the median increase in fatalities is 1.1 and 2.4 additional fatalities per 100,000 for eruptions on day 1 and 100 respectively, and 60.0 additional fatalities per 100,000 for an eruption close to the peak in infections (day 50). Conclusion Our results show that the occurrence of a natural disaster in most cases leads to an increase in infection related fatalities, with wide variance in possible outcomes depending on the timing of the natural disaster relative to the peak in infections and the duration of the natural disaster.

scholarly journals Milk protein and human health: A review

2018 ◽  
Vol 33 (01) ◽  
Author(s):  
Sarita Kumari ◽  
Anurag Pandey ◽  
Priyanka Meena ◽  
Rahul Choudhary
Keyword(s):  
Cardiovascular Disease ◽  
Human Health ◽  
Neurological Disorder ◽  
Milk Protein ◽  
Health Related ◽  
Beta Casein ◽  
Dairy Animals

Milk is an almost ideal food. Most common economically important milk constituents include fat, protein, SNF, lactose and ash. In milk constituents, beta- casein has gained importance and popularity among the health conscious people due to its recent health related issues. Milk is often found two types of beta-casein i.e. A-1 and A-2. Our indigenous dairy animals produce A2 type of milk. A2 Milk protects against diabetes, cardiovascular disease and neurological disorder and also increases the immunity of body disease. The main purpose behind this article is to make people aware about the A2 milk and their benefits.

scholarly journals The landscape of micro-inversions provides clues for population genetic analysis of humans

2020 ◽  
Author(s):  
Li Qu ◽  
Luotong Wang ◽  
Feifei He ◽  
Yilun Han ◽  
Longshu Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Nonhuman Primate ◽  
Nonhuman Primates ◽  
Genetic Diseases ◽  
Potential Effect ◽  
Human Migration ◽  
Human Populations ◽  
Population Genetic Analysis ◽  
Phylogenetic Structure ◽  
Migration History

AbstractBackgroundVariations in the human genome have been studied extensively. However, little is known about the role of micro-inversions (MIs), generally defined as small (<100 bp) inversions, in human evolution, diversity, and health. Depicting the pattern of MIs among diverse populations is critical for interpreting human evolutionary history and obtaining insight into genetic diseases.ResultsIn this paper, we explored the distribution of MIs in genomes from 26 human populations and 7 nonhuman primate genomes and analyzed the phylogenetic structure of the 26 human populations based on the MIs. We further investigated the functions of the MIs located within genes associated with human health. With hg19 as the reference genome, we detected 6,968 MIs among the 1,937 human samples and 24,476 MIs among the 7 nonhuman primate genomes. The analyses of MIs in human genomes showed that the MIs were rarely located in exonic regions. Nonhuman primates and human populations shared only 82 inverted alleles, and Africans had the most inverted alleles in common with nonhuman primates, which was consistent with the “Out of Africa” hypothesis. The clustering of MIs among the human populations also coincided with human migration history and ancestral lineages.ConclusionsWe propose that MIs are potential evolutionary markers for investigating population dynamics. Our results revealed the diversity of MIs in human populations and showed that they are essential to constructing human population relationships and have a potential effect on human health.

scholarly journals The Global Scenario of A1, A2 β-Casein Variant in Cattle and its Impact on Human Health

2021 ◽  
Vol 3 (1) ◽  
pp. 16-24
Author(s):  
Neena Amatya Gorkhali ◽  
Chhiring Sherpa ◽  
Prashanna Koirala ◽  
Saroj Sapkota ◽  
Bhoj Raj Pokharel
Keyword(s):  
Adverse Effects ◽  
Human Health ◽  
Human Diseases ◽  
Cattle Breeds ◽  
Beta Casein ◽  
Adequate Research

Beta casein (β-casein) has gained considerable interest among scientists and farmers as it provides promising factors to milk that enhance its quality and concentration. It is believed that the A1 β-casein variant shares an association with numerous human diseases. Since there are numerous hypotheses concerning the link between variants of β-casein and human diseases, many researchers across the globe have genotyped the cattle in terms of A1, A2 β-casein variants. This paper catalogs the A1 and A2 β-casein genotypes shared by different cattle breeds across the globe. Various literature encompassing the adverse effects of β-casein variants were assessed adequately. This paper suggests that the effects of undertaking the A1 β-casein variant on human health are ambiguous. Adequate research providing stronger evidence is needed for understanding the effects imparted by the consumption of both A1 and A2 β-casein variants on human health.

scholarly journals Natural products as mediators of disease

2017 ◽  
Vol 34 (2) ◽  
pp. 194-219 ◽  
Author(s):  
Neha Garg ◽  
Tal Luzzatto-Knaan ◽  
Alexey V. Melnik ◽  
Andrés Mauricio Caraballo-Rodríguez ◽  
Dimitrios J. Floros ◽  
...  
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Human Health ◽  
Potential Effect ◽  
Specialized Metabolites ◽  
Natural Product Research

The potential effect of microbiome-derived specialized metabolites on human health provides new and exciting avenues for natural product research.

scholarly journals Bovine beta casein A1 variant as risk factor for human health

2016 ◽  
Vol 19 (Special issue) ◽  
pp. 48-51
Author(s):  
Martina Miluchová ◽  
Michal Gábor ◽  
Anna Trakovická ◽  
Jana Hanusová
Keyword(s):  
Risk Factor ◽  
Human Health ◽  
Beta Casein

scholarly journals Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution and Effect on Human Health

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1229
Author(s):  
Giuseppe Mannino ◽  
Giorgia Chinigò ◽  
Graziella Serio ◽  
Tullio Genova ◽  
Carla Gentile ◽  
...  
Keyword(s):  
Human Health ◽  
Potential Effect ◽  
Lipid Lowering ◽  
Forest Plot ◽  
Human Diet ◽  
Potential Health ◽  
Plant Parts ◽  
Complete Report ◽  
Plant Families ◽  
Plant Sources

Proanthocyanidins (PACs) are a class of polyphenolic compounds that are attracting considerable interest in the nutraceutical field due to their potential health benefits. However, knowledge about the chemistry, biosynthesis, and distribution of PACs is limited. This review summarizes the main chemical characteristics and biosynthetic pathways and the main analytical methods aimed at their identification and quantification in raw plant matrices. Furthermore, meta-analytic approaches were used to identify the main plant sources in which PACs were contained and to investigate their potential effect on human health. In particular, a cluster analysis identified PACs in 35 different plant families and 60 different plant parts normally consumed in the human diet. On the other hand, a literature search, coupled with forest plot analyses, highlighted how PACs can be actively involved in both local and systemic effects. Finally, the potential mechanisms of action through which PACs may impact human health were investigated, focusing on their systemic hypoglycemic and lipid-lowering effects and their local anti-inflammatory actions on the intestinal epithelium. Overall, this review may be considered a complete report in which chemical, biosynthetic, ecological, and pharmacological aspects of PACs are discussed.

scholarly journals The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans

2020 ◽  
Vol 12 (4) ◽  
pp. 499-514
Author(s):  
Li Qu ◽  
Luotong Wang ◽  
Feifei He ◽  
Yilun Han ◽  
Longshu Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Nonhuman Primate ◽  
Nonhuman Primates ◽  
Genetic Diseases ◽  
Potential Effect ◽  
Human Migration ◽  
Human Populations ◽  
Population Genetic Analysis ◽  
Phylogenetic Structure ◽  
Migration History

Abstract Background Variations in the human genome have been studied extensively. However, little is known about the role of micro-inversions (MIs), generally defined as small (< 100 bp) inversions, in human evolution, diversity, and health. Depicting the pattern of MIs among diverse populations is critical for interpreting human evolutionary history and obtaining insight into genetic diseases. Results In this paper, we explored the distribution of MIs in genomes from 26 human populations and 7 nonhuman primate genomes and analyzed the phylogenetic structure of the 26 human populations based on the MIs. We further investigated the functions of the MIs located within genes associated with human health. With hg19 as the reference genome, we detected 6968 MIs among the 1937 human samples and 24,476 MIs among the 7 nonhuman primate genomes. The analyses of MIs in human genomes showed that the MIs were rarely located in exonic regions. Nonhuman primates and human populations shared only 82 inverted alleles, and Africans had the most inverted alleles in common with nonhuman primates, which was consistent with the “Out of Africa” hypothesis. The clustering of MIs among the human populations also coincided with human migration history and ancestral lineages. Conclusions We propose that MIs are potential evolutionary markers for investigating population dynamics. Our results revealed the diversity of MIs in human populations and showed that they are essential to construct human population relationships and have a potential effect on human health.

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