scholarly journals Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

Diabetes ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 3256-3264 ◽  
Author(s):  
N. R. Bolo ◽  
G. Musen ◽  
A. M. Jacobson ◽  
K. Weinger ◽  
R. L. McCartney ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Activation

scholarly journals Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Geisa B. Gallardo-Moreno ◽  
Andrés A. González-Garrido ◽  
Esteban Gudayol-Ferré ◽  
Joan Guàrdia-Olmos
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Young Patients ◽  
Brain Activation ◽  
Behavioral Performance ◽  
Visuospatial Working Memory ◽  
Control Subjects ◽  
Compensation Mechanisms ◽  
Healthy Control

In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1Dversushealthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

Type 1 diabetes affects the brain functional connectivity underlying working memory processing

2021 ◽  
Author(s):  
Geisa B. Gallardo‐Moreno ◽  
Francisco J. Alvarado‐Rodríguez ◽  
Rebeca Romo‐Vázquez ◽  
Hugo Vélez‐Pérez ◽  
Andrés A. González‐Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Memory Processing ◽  
Brain Functional Connectivity ◽  
The Brain

scholarly journals Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178172 ◽  
Author(s):  
Joan Guàrdia-Olmos ◽  
Geisa B. Gallardo-Moreno ◽  
Esteve Gudayol-Ferré ◽  
Maribel Peró-Cebollero ◽  
Andrés A. González-Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Task Complexity ◽  
Verbal Task ◽  
Fmri Study

scholarly journals Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial

Diabetologia ◽  
2017 ◽  
Vol 61 (3) ◽  
pp. 551-561 ◽  
Author(s):  
Michael Gejl ◽  
Albert Gjedde ◽  
Birgitte Brock ◽  
Arne Møller ◽  
Eelco van Duinkerken ◽  
...  
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Crossover Trial ◽  
Regional Cerebral Blood

Glucose Changes and Working Memory in Individuals with Type 1 Diabetes During Air Pressure Changes Simulating Skydiving

2014 ◽  
Vol 16 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Mohammad Yousef ◽  
Anton Westman ◽  
Ann Lindberg ◽  
Cecilia de Lacerda ◽  
Johan Jendle
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Air Pressure ◽  
Pressure Changes

scholarly journals Regional Brain Activation during Hypoglycemia in Type 1 Diabetes

2008 ◽  
Vol 93 (4) ◽  
pp. 1450-1457 ◽  
Author(s):  
Gail Musen ◽  
Donald C. Simonson ◽  
Nicolas R. Bolo ◽  
Amy Driscoll ◽  
Katie Weinger ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Brain Activation ◽  
Regional Brain

scholarly journals Short-Term, Delayed, and Working Memory Are Impaired During Hypoglycemia in Individuals With Type 1 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (2) ◽  
pp. 390-396 ◽  
Author(s):  
A. J. Sommerfield ◽  
I. J. Deary ◽  
V. McAulay ◽  
B. M. Frier
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Short Term

scholarly journals Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory

Diabetes ◽  
2020 ◽  
Vol 69 (8) ◽  
pp. 1770-1778
Author(s):  
Lara C. Foland-Ross ◽  
Gabby Tong ◽  
Nelly Mauras ◽  
Allison Cato ◽  
Tandy Aye ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Functional Mri ◽  
Brain Function ◽  
Mri Study

scholarly journals Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1941-1944 ◽  
Author(s):  
Jasna Šuput Omladič ◽  
Anka Slana Ozimič ◽  
Andrej Vovk ◽  
Dušan Šuput ◽  
Grega Repovš ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Spatial Working Memory ◽  
Acute Hyperglycemia

scholarly journals Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes

2020 ◽  
Author(s):  
Jasna Šuput Omladič ◽  
Anka Slana Ozimič ◽  
Andrej Vovk ◽  
Dušan Šuput ◽  
Grega Repovš ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Function ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Acute Hyperglycemia ◽  
Hyperglycemic Clamp ◽  
Design And Methods ◽  
Scanning Session

<i>Objective:</i> <a>To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes.</a> <p><i><br></i></p><p><i>Research Design and Methods:</i><b> </b>Twenty participants with type 1 diabetes (T1D) (age 14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed two functional magnetic resonance imaging sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L (360 mg/dL)).<b> </b></p> <p><i><br></i></p><p><i>Results:</i> Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the spatial working memory task (p=0.014) were observed.<b> </b><b></b></p> <p><i><br></i></p><p><i>Conclusions</i>: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.</p>

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