scholarly journals Regional Brain Activation during Hypoglycemia in Type 1 Diabetes

2008 ◽  
Vol 93 (4) ◽  
pp. 1450-1457 ◽  
Author(s):  
Gail Musen ◽  
Donald C. Simonson ◽  
Nicolas R. Bolo ◽  
Amy Driscoll ◽  
Katie Weinger ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Brain Activation ◽  
Regional Brain

scholarly journals Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Geisa B. Gallardo-Moreno ◽  
Andrés A. González-Garrido ◽  
Esteban Gudayol-Ferré ◽  
Joan Guàrdia-Olmos
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Young Patients ◽  
Brain Activation ◽  
Behavioral Performance ◽  
Visuospatial Working Memory ◽  
Control Subjects ◽  
Compensation Mechanisms ◽  
Healthy Control

In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1Dversushealthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

scholarly journals Regional Brain Volume Differences Associated With Hyperglycemia and Severe Hypoglycemia in Youth With Type 1 Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (9) ◽  
pp. 2331-2337 ◽  
Author(s):  
D. C. Perantie ◽  
J. Wu ◽  
J. M. Koller ◽  
A. Lim ◽  
S. L. Warren ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Brain Volume ◽  
Severe Hypoglycemia ◽  
Regional Brain ◽  
Regional Brain Volume

scholarly journals Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

Diabetes ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 3256-3264 ◽  
Author(s):  
N. R. Bolo ◽  
G. Musen ◽  
A. M. Jacobson ◽  
K. Weinger ◽  
R. L. McCartney ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Activation

scholarly journals Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Misun Hwang ◽  
Dana L. Tudorascu ◽  
Karen Nunley ◽  
Helmet Karim ◽  
Howard J. Aizenstein ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Parietal Lobe ◽  
Response Times ◽  
Small Vessel Disease ◽  
Inferior Frontal Gyrus ◽  
Brain Activation ◽  
Small Vessel ◽  
Psychomotor Speed ◽  
Vessel Disease

Slower psychomotor speed is very common in patients with type 1 diabetes mellitus (T1D), but the underlying mechanisms are not clear. We propose that hyperglycemia is associated with slower psychomotor speed via disruption of brain activation. Eighty-five adults (48% women, mean age: 49.0 years, mean duration: 40.8) with childhood onset T1D were recruited for this cross-sectional study. Median response time in seconds (longer = worse performance) and brain activation were measured while performing a psychomotor speed task. Exposure to hyperglycemia, measured as glycosylated hemoglobin A1c, was associated with longer response time and with higher activation in the inferior frontal gyrus and primary sensorimotor and dorsal cingulate cortex. Higher activation in inferior frontal gyrus, primary sensorimotor cortex, thalamus, and cuneus was related to longer response times; in contrast, higher activation in the superior parietal lobe was associated with shorter response times. Associations were independent of small vessel disease in the brain or other organs. In this group of middle-aged adults with T1D, the pathway linking chronic hyperglycemia with slower processing speed appears to include increased brain activation, but not small vessel disease. Activation in the superior parietal lobe may compensate for dysregulation in brain activation in the presence of hyperglycemia.

scholarly journals The impact of hypoglycaemia awareness status on regional brain responses to acute hypoglycaemia in men with type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 61 (7) ◽  
pp. 1676-1687 ◽  
Author(s):  
Joel T. Dunn ◽  
Pratik Choudhary ◽  
Ming Ming Teh ◽  
Ian Macdonald ◽  
Katharine F. Hunt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Regional Brain ◽  
Brain Responses ◽  
The Impact ◽  
Hypoglycaemia Awareness
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