Type 1 diabetes affects the brain functional connectivity underlying working memory processing

2021 ◽  
Author(s):  
Geisa B. Gallardo‐Moreno ◽  
Francisco J. Alvarado‐Rodríguez ◽  
Rebeca Romo‐Vázquez ◽  
Hugo Vélez‐Pérez ◽  
Andrés A. González‐Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Memory Processing ◽  
Brain Functional Connectivity ◽  
The Brain

Type-1 diabetes shapes working memory processing strategies

2019 ◽  
Vol 49 (5) ◽  
pp. 347-357
Author(s):  
Francisco Javier Alvarado-Rodríguez ◽  
Rebeca Romo-Vázquez ◽  
Geisa Bearitz Gallardo-Moreno ◽  
Hugo Vélez-Pérez ◽  
Andrés Antonio González-Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Memory Processing ◽  
Processing Strategies

Type 1 diabetes and working memory processing of emotional faces

2019 ◽  
Vol 363 ◽  
pp. 173-181 ◽  
Author(s):  
Andrés A. González-Garrido ◽  
Geisa B. Gallardo-Moreno ◽  
Fabiola R. Gómez-Velázquez
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Memory Processing ◽  
Emotional Faces

scholarly journals Altered Brain Dynamics in Patients With Type 1 Diabetes During Working Memory Processing

Diabetes ◽  
2018 ◽  
Vol 67 (6) ◽  
pp. 1140-1148 ◽  
Author(s):  
Christine M. Embury ◽  
Alex I. Wiesman ◽  
Amy L. Proskovec ◽  
Elizabeth Heinrichs-Graham ◽  
Timothy J. McDermott ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Dynamics ◽  
Memory Processing

scholarly journals Differential resting state connectivity responses to glycemic state in type 1 diabetes

2019 ◽  
Author(s):  
Lisa Parikh ◽  
Dongju Seo ◽  
Cheryl Lacadie ◽  
Renata Belfort-DeAguiar ◽  
Derek Groskreutz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Resting State ◽  
Medical Center ◽  
Academic Medical Center ◽  
Angular Gyrus ◽  
Resting State Functional Connectivity ◽  
The Impact ◽  
Resting State Connectivity

Abstract Context Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain’s resting state activity remains unclear. Objective To determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware). Design Observational study Setting Academic medical center Participants 27 individuals with T1DM and 12 healthy control volunteers participated in the study. Intervention All participants underwent BOLD resting state fMRI brain imaging during a 2-step hyperinsulinemic euglycemic (90 mg/dl)-hypoglycemic (60mg/dl) clamp. Outcome Changes in resting state functional connectivity Results Using two separate methods of functional connectivity analysis, we identified distinct differences in the resting state brain responses to mild hypoglycemia amongst HC, T1DM-Aware and T1DM-Unaware participants, particularly in the angular gyrus, an integral component of the default mode network (DMN). Furthermore, changes in angular gyrus connectivity also correlated with greater symptoms of hypoglycemia (r = 0.461, P = 0.003) as well as higher scores of perceived stress (r = 0.531, P = 0.016). Conclusion These findings provide evidence that individuals with T1DM have changes in the brain’s resting state connectivity patterns, which may be further associated with differences in awareness to hypoglycemia. These changes in connectivity may be associated with alterations in functional outcomes amongst individuals with T1DM.

scholarly journals Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178172 ◽  
Author(s):  
Joan Guàrdia-Olmos ◽  
Geisa B. Gallardo-Moreno ◽  
Esteve Gudayol-Ferré ◽  
Maribel Peró-Cebollero ◽  
Andrés A. González-Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Task Complexity ◽  
Verbal Task ◽  
Fmri Study

scholarly journals Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial

Diabetologia ◽  
2017 ◽  
Vol 61 (3) ◽  
pp. 551-561 ◽  
Author(s):  
Michael Gejl ◽  
Albert Gjedde ◽  
Birgitte Brock ◽  
Arne Møller ◽  
Eelco van Duinkerken ◽  
...  
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Crossover Trial ◽  
Regional Cerebral Blood
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