scholarly journals Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1941-1944 ◽  
Author(s):  
Jasna Šuput Omladič ◽  
Anka Slana Ozimič ◽  
Andrej Vovk ◽  
Dušan Šuput ◽  
Grega Repovš ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Spatial Working Memory ◽  
Acute Hyperglycemia

scholarly journals Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes

2020 ◽  
Author(s):  
Jasna Šuput Omladič ◽  
Anka Slana Ozimič ◽  
Andrej Vovk ◽  
Dušan Šuput ◽  
Grega Repovš ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Function ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Acute Hyperglycemia ◽  
Hyperglycemic Clamp ◽  
Design And Methods ◽  
Scanning Session

<i>Objective:</i> <a>To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes.</a> <p><i><br></i></p><p><i>Research Design and Methods:</i><b> </b>Twenty participants with type 1 diabetes (T1D) (age 14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed two functional magnetic resonance imaging sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L (360 mg/dL)).<b> </b></p> <p><i><br></i></p><p><i>Results:</i> Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the spatial working memory task (p=0.014) were observed.<b> </b><b></b></p> <p><i><br></i></p><p><i>Conclusions</i>: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.</p>

scholarly journals Acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes

2020 ◽  
Author(s):  
Jasna Šuput Omladič ◽  
Anka Slana Ozimič ◽  
Andrej Vovk ◽  
Dušan Šuput ◽  
Grega Repovš ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Brain Function ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Acute Hyperglycemia ◽  
Hyperglycemic Clamp ◽  
Design And Methods ◽  
Scanning Session

<i>Objective:</i> <a>To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes.</a> <p><i><br></i></p><p><i>Research Design and Methods:</i><b> </b>Twenty participants with type 1 diabetes (T1D) (age 14.64 ±1.78 years) and 20 age-matched healthy controls (age 14.40± 2.82 years) performed two functional magnetic resonance imaging sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L (360 mg/dL)).<b> </b></p> <p><i><br></i></p><p><i>Results:</i> Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the spatial working memory task (p=0.014) were observed.<b> </b><b></b></p> <p><i><br></i></p><p><i>Conclusions</i>: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.</p>

Type 1 diabetes affects the brain functional connectivity underlying working memory processing

2021 ◽  
Author(s):  
Geisa B. Gallardo‐Moreno ◽  
Francisco J. Alvarado‐Rodríguez ◽  
Rebeca Romo‐Vázquez ◽  
Hugo Vélez‐Pérez ◽  
Andrés A. González‐Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Memory Processing ◽  
Brain Functional Connectivity ◽  
The Brain

scholarly journals Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178172 ◽  
Author(s):  
Joan Guàrdia-Olmos ◽  
Geisa B. Gallardo-Moreno ◽  
Esteve Gudayol-Ferré ◽  
Maribel Peró-Cebollero ◽  
Andrés A. González-Garrido
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Task Complexity ◽  
Verbal Task ◽  
Fmri Study

scholarly journals Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial

Diabetologia ◽  
2017 ◽  
Vol 61 (3) ◽  
pp. 551-561 ◽  
Author(s):  
Michael Gejl ◽  
Albert Gjedde ◽  
Birgitte Brock ◽  
Arne Møller ◽  
Eelco van Duinkerken ◽  
...  
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Crossover Trial ◽  
Regional Cerebral Blood

Dynamic changes in retinal vessel diameter during acute hyperglycemia in type 1 diabetes

2018 ◽  
Vol 32 (2) ◽  
pp. 234-239 ◽  
Author(s):  
Brian C. Bucca ◽  
David M. Maahs ◽  
Janet K. Snell-Bergeon ◽  
John Hokanson ◽  
Sean Rinella ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Retinal Vessel ◽  
Vessel Diameter ◽  
Dynamic Changes ◽  
Acute Hyperglycemia ◽  
Retinal Vessel Diameter

Glucose Changes and Working Memory in Individuals with Type 1 Diabetes During Air Pressure Changes Simulating Skydiving

2014 ◽  
Vol 16 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Mohammad Yousef ◽  
Anton Westman ◽  
Ann Lindberg ◽  
Cecilia de Lacerda ◽  
Johan Jendle
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Air Pressure ◽  
Pressure Changes

scholarly journals Short-Term, Delayed, and Working Memory Are Impaired During Hypoglycemia in Individuals With Type 1 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (2) ◽  
pp. 390-396 ◽  
Author(s):  
A. J. Sommerfield ◽  
I. J. Deary ◽  
V. McAulay ◽  
B. M. Frier
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Short Term

scholarly journals Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory

Diabetes ◽  
2020 ◽  
Vol 69 (8) ◽  
pp. 1770-1778
Author(s):  
Lara C. Foland-Ross ◽  
Gabby Tong ◽  
Nelly Mauras ◽  
Allison Cato ◽  
Tandy Aye ◽  
...  
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Functional Mri ◽  
Brain Function ◽  
Mri Study

scholarly journals Effects of methylphenidate on cognition and behaviour in children with neurofibromatosis type 1: a study protocol for a randomised placebo-controlled crossover trial

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e021800 ◽  
Author(s):  
Natalie A Pride ◽  
Belinda Barton ◽  
Paul Hutchins ◽  
David R Coghill ◽  
Mayuresh S Korgaonkar ◽  
...  
Keyword(s):  
Working Memory ◽  
Neurofibromatosis Type 1 ◽  
Performance Test ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Neurofibromatosis Type ◽  
Fine Motor ◽  
Mouse Strains ◽  
Adhd Symptoms

IntroductionDopamine dysregulation has been identified as a key modulator of behavioural impairment in neurofibromatosis type 1 (NF1) and a potential therapeutic target. Preclinical research demonstrates reduced dopamine in the brains of genetically engineered NF1 mouse strains is associated with reduced spatial-learning and attentional dysfunction. Methylphenidate, a stimulant medication that increases dopaminergic and noradrenergic neurotransmission, rescued the behavioural and dopamine abnormalities. Although preliminary clinical trials have demonstrated that methylphenidate is effective in treating attention deficit hyperactivity disorder (ADHD) symptoms in children with NF1, its therapeutic effect on cognitive performance is unclear. The primary aim of this clinical trial is to assess the efficacy of methylphenidate for reducing attention deficits, spatial working memory impairments and ADHD symptoms in children with NF1.Methods and analysisA randomised, double-blind, placebo-controlled trial of methylphenidate with a two period crossover design. Thirty-six participants with NF1 aged 7–16 years will be randomised to one of two treatment sequences: 6 weeks of methylphenidate followed by 6 weeks of placebo or; 6 weeks of placebo followed by 6 weeks of methylphenidate. Neurocognitive and behavioural outcomes as well as neuroimaging measures will be completed at baseline and repeated at the end of each treatment condition (week 6, week 12). Primary outcome measures are omission errors on the Conners Continuous Performance Test-II (attention), between-search errors on the Spatial Working Memory task from the Cambridge Neuropsychological Test Automated Battery (spatial working memory) and the Inattentive and Hyperactivity/Impulsivity Symptom Scales on the Conners 3-Parent. Secondary outcomes will examine the effect of methylphenidate on executive functions, attention, visuospatial skills, behaviour, fine-motor skills, language, social skills and quality of life.Ethics and disseminationThis trial has hospital ethics approval and the results will be disseminated through peer-reviewed publications and international conferences.Trial registration numberACTRN12611000765921.

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