scholarly journals Dual local drug delivery of vancomycin and farnesol for mitigation of MRSA infection in vivo – a pilot study

2020 ◽  
Vol 40 ◽  
pp. 38-57
Author(s):  
UC Woelfle ◽  
◽  
T Briggs ◽  
S Bhattacharyya ◽  
H Qu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pilot Study ◽  
Local Drug Delivery ◽  
Mrsa Infection

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Concept for a gas-cell-driven drug delivery system for therapeutic applications

2011 ◽  
Vol 225 (12) ◽  
pp. 1196-1201 ◽  
Author(s):  
S Becker ◽  
T Xu ◽  
F Ilchmann ◽  
J Eisler ◽  
B Wolf
Keyword(s):  
Energy Source ◽  
Drug Delivery ◽  
Pain Management ◽  
Local Drug Delivery ◽  
Gas Cell ◽  
External Energy ◽  
Micro Pump ◽  
Drug Reservoir ◽  
External Energy Source

This paper presents a concept for an implantable micro-pump based on hydrogen- generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 μl/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.

Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery

Circulation ◽  
1997 ◽  
Vol 96 (2) ◽  
pp. 636-645 ◽  
Author(s):  
Dorothea I. Axel ◽  
Wolfgang Kunert ◽  
Christoph Göggelmann ◽  
Martin Oberhoff ◽  
Christian Herdeg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Local Drug Delivery ◽  
Arterial Smooth Muscle Cell ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery

2010 ◽  
Vol 99 (7) ◽  
pp. 3009-3018 ◽  
Author(s):  
Sheng-Rong Guo ◽  
Zhong-Min Wang ◽  
Ya-Qiong Zhang ◽  
Lei Lei ◽  
Jing-Min Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
In Vivo Evaluation ◽  
Nitinol Stent

Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study

The Prostate ◽  
2017 ◽  
Vol 77 (13) ◽  
pp. 1356-1365 ◽  
Author(s):  
Werner J. Struss ◽  
Zheng Tan ◽  
Payam Zachkani ◽  
Igor Moskalev ◽  
John K. Jackson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated
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