Preliminary evaluation of local drug delivery of amphotericin B and in vivo degradation of chitosan and polyethylene glycol blended sponges

2015 ◽  
Vol 104 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Ashley Cox Parker ◽  
Cheyenne Rhodes ◽  
Jessica Amber Jennings ◽  
Lauren Hittle ◽  
Mark Shirtliff ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Amphotericin B ◽  
Local Drug Delivery ◽  
Preliminary Evaluation ◽  
In Vivo Degradation

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Concept for a gas-cell-driven drug delivery system for therapeutic applications

2011 ◽  
Vol 225 (12) ◽  
pp. 1196-1201 ◽  
Author(s):  
S Becker ◽  
T Xu ◽  
F Ilchmann ◽  
J Eisler ◽  
B Wolf
Keyword(s):  
Energy Source ◽  
Drug Delivery ◽  
Pain Management ◽  
Local Drug Delivery ◽  
Gas Cell ◽  
External Energy ◽  
Micro Pump ◽  
Drug Reservoir ◽  
External Energy Source

This paper presents a concept for an implantable micro-pump based on hydrogen- generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 μl/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.

In vivo degradation of semi-rigid polymeric films made of alginate and polyethylene glycol

2005 ◽  
Vol 45 (4) ◽  
pp. 421-427 ◽  
Author(s):  
Maya Livnat ◽  
Eli Peled ◽  
Jochanan Boss ◽  
Dror Seliktar
Keyword(s):  
Polyethylene Glycol ◽  
Polymeric Films ◽  
In Vivo Degradation

Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery

Circulation ◽  
1997 ◽  
Vol 96 (2) ◽  
pp. 636-645 ◽  
Author(s):  
Dorothea I. Axel ◽  
Wolfgang Kunert ◽  
Christoph Göggelmann ◽  
Martin Oberhoff ◽  
Christian Herdeg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Local Drug Delivery ◽  
Arterial Smooth Muscle Cell ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo

2017 ◽  
Vol 5 (8) ◽  
pp. 1542-1550 ◽  
Author(s):  
Benqing Zhou ◽  
Lingzhou Zhao ◽  
Mingwu Shen ◽  
Jinhua Zhao ◽  
Xiangyang Shi
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Polyethylenimine can be modified with folic acid through a polyethylene glycol spacer for targeted anticancer drug delivery to tumors.

Synthesis and Characterization of DAM-1 type Materials

2000 ◽  
Vol 628 ◽  
Author(s):  
Kenneth J. Balkus ◽  
Decio Coutinho ◽  
Jessica Lucas ◽  
Lisa Washmon-Kriel
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Amorphous Material ◽  
Synthesis And Characterization ◽  
Preliminary Evaluation ◽  
Physiological Conditions ◽  
Vitamin E Tpgs ◽  
Polyethylene Glycol 1000 ◽  
Gel Composition

ABSTRACTVitamin E-TPGS (α-tocopheryl polyethylene glycol 1000 succinate) was found to be an effective template for the preparation of a novel hexagonal mesoporous silica referred to as DAM-1 (Dallas Amorphous Material-1). Depending upon the temperature and gel composition various morphologies can be achieved, including spheres, gyroids, discoids, hexagonal plates and rods. Characterization of these composites as well as a preliminary evaluation of DAM-1 as a drug delivery system under physiological conditions is also presented.

Controlled in Vivo Degradation of Genipin Crosslinked Polyethylene Glycol Hydrogels within Osteochondral Defects

2006 ◽  
Vol 0 (0) ◽  
pp. 060810081933001
Author(s):  
Mario Ferretti ◽  
Kacey G. Marra ◽  
Kenji Kobayashi ◽  
Alicia J. Defail ◽  
Constance R. Chu
Keyword(s):  
Polyethylene Glycol ◽  
Osteochondral Defects ◽  
In Vivo Degradation
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