scholarly journals A fluorescent chromophore TOTO-3 as a ‘smart probe’ for the assessment of ultrasound-mediated local drug delivery in vivo

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Roel Deckers ◽  
Anna Yudina ◽  
Laura C. Cardoit ◽  
Chrit T. W. Moonen
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Concept for a gas-cell-driven drug delivery system for therapeutic applications

2011 ◽  
Vol 225 (12) ◽  
pp. 1196-1201 ◽  
Author(s):  
S Becker ◽  
T Xu ◽  
F Ilchmann ◽  
J Eisler ◽  
B Wolf
Keyword(s):  
Energy Source ◽  
Drug Delivery ◽  
Pain Management ◽  
Local Drug Delivery ◽  
Gas Cell ◽  
External Energy ◽  
Micro Pump ◽  
Drug Reservoir ◽  
External Energy Source

This paper presents a concept for an implantable micro-pump based on hydrogen- generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 μl/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.

Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery

Circulation ◽  
1997 ◽  
Vol 96 (2) ◽  
pp. 636-645 ◽  
Author(s):  
Dorothea I. Axel ◽  
Wolfgang Kunert ◽  
Christoph Göggelmann ◽  
Martin Oberhoff ◽  
Christian Herdeg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Local Drug Delivery ◽  
Arterial Smooth Muscle Cell ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery

2010 ◽  
Vol 99 (7) ◽  
pp. 3009-3018 ◽  
Author(s):  
Sheng-Rong Guo ◽  
Zhong-Min Wang ◽  
Ya-Qiong Zhang ◽  
Lei Lei ◽  
Jing-Min Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
In Vivo Evaluation ◽  
Nitinol Stent

scholarly journals A Two-Photon Microimaging-Microdevice System for Four-Dimensional Imaging of Local Drug Delivery in Tissues

2021 ◽  
Vol 22 (21) ◽  
pp. 11752
Author(s):  
Guigen Liu ◽  
Veronica Valvo ◽  
Sebastian W. Ahn ◽  
Devon Thompson ◽  
Kyle Deans ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Immune Cell ◽  
Drug Distribution ◽  
Study Drug ◽  
Tissue Response ◽  
Local Drug Delivery ◽  
Two Photon ◽  
Tissue Responses

Advances in the intratumor measurement of drug responses have included a pioneering biomedical microdevice for high throughput drug screening in vivo, which was further advanced by integrating a graded-index lens based two-dimensional fluorescence micro-endoscope to monitor tissue responses in situ across time. While the previous system provided a bulk measurement of both drug delivery and tissue response from a given region of the tumor, it was incapable of visualizing drug distribution and tissue responses in a three-dimensional (3D) way, thus missing the critical relationship between drug concentration and effect. Here we demonstrate a next-generation system that couples multiplexed intratumor drug release with continuous 3D spatial imaging of the tumor microenvironment via the integration of a miniaturized two-photon micro-endoscope. This enables optical sectioning within the live tissue microenvironment to effectively profile the entire tumor region adjacent to the microdevice across time. Using this novel microimaging-microdevice (MI-MD) system, we successfully demonstrated the four-dimensional imaging (3 spatial dimensions plus time) of local drug delivery in tissue phantom and tumors. Future studies include the use of the MI-MD system for monitoring of localized intra-tissue drug release and concurrent measurement of tissue responses in live organisms, with applications to study drug resistance due to nonuniform drug distribution in tumors, or immune cell responses to anti-cancer agents.

A New Micro-holder Device for Local Drug Delivery during In Vivo Whole-cell Recordings

Neuroscience ◽  
2018 ◽  
Vol 381 ◽  
pp. 115-123 ◽  
Author(s):  
María Sáez ◽  
Maya Ketzef ◽  
Javier Alegre-Cortés ◽  
Ramón Reig ◽  
Gilad Silberberg
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
Whole Cell ◽  
Whole Cell Recordings

Periodontal Treatment by Local Drug Delivery Using Resorbable Base Material

1988 ◽  
Vol 2 (2) ◽  
pp. 401-404 ◽  
Author(s):  
T. Noguchi ◽  
M. Fukuda ◽  
I. Ishikawa
Keyword(s):  
Drug Delivery ◽  
Gingival Crevicular Fluid ◽  
Clinical Manifestations ◽  
Base Material ◽  
Local Drug Delivery ◽  
Subgingival Plaque ◽  
Initial Examination ◽  
Microbial Composition

The effects of local drug delivery to the subgingival plaque flora using resorbable base material were evaluated by the study of microbial composition in periodontal pockets and clinical manifestations of disease. In vitro, the drug used in this study was released within 24 hr from the hydroxypropylcellulose (HPC) strips. In vivo release of the drug from strips was also measured in nine patients who had, contralaterally, deep pockets of more than 5 mm. A tetracycline (TC)-containing HPC strip was inserted in one pocket, and a blank strip without TC was inserted in the other pocket. The amount of TC in the gingival crevicular fluid (GCF) 24 hr after insertion of the strip was significantly higher than that of the control. Ten subjects, who had at least three pockets greater than 4 mm in depth, were selected from 50 volunteers after an initial examination. HPC strips containing TC, chlorhexidine (CH), and control (base material) were inserted into each pocket three times a week. Clinical and microbiological changes ascertained by darkfield microscopy were monitored over three weeks. Reduction of both probing depth and bleeding-on-probing was observed only in the pockets in which TC was administered. Changes of microbial composition of subgingival plaque were, however, found in both TC- and CH-treated pockets. The percentages of spirochetes and motile rods were remarkably reduced in these pockets.

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