Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study

The Prostate ◽  
2017 ◽  
Vol 77 (13) ◽  
pp. 1356-1365 ◽  
Author(s):  
Werner J. Struss ◽  
Zheng Tan ◽  
Payam Zachkani ◽  
Igor Moskalev ◽  
John K. Jackson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated

A cylindrical magnetically-actuated drug delivery device proposed for minimally invasive treatment of prostate cancer

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 98087-98096 ◽  
Author(s):  
P. Zachkani ◽  
J. K. Jackson ◽  
F. N. Pirmoradi ◽  
M. Chiao
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Minimally Invasive ◽  
Cancer Treatment ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Prostate Cancer Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated

A cylindrical magnetically-actuated MEMS drug delivery device, implanted through a needle for localized prostate cancer treatment is proposed.

scholarly journals Individualized minimally invasive treatment for adult testicular hydrocele: A pilot study

2019 ◽  
Vol 7 (6) ◽  
pp. 727-733
Author(s):  
Le Lin ◽  
Huai-Shan Hong ◽  
Yun-Liang Gao ◽  
Jin-Rui Yang ◽  
Tao Li ◽  
...  
Keyword(s):  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment

In vivo tolerance and kinetics of a novel ocular drug delivery device

2006 ◽  
Vol 116 (2) ◽  
pp. e47-e49 ◽  
Author(s):  
R.T. Pijls ◽  
H.H.L. Hanssen ◽  
R.M.M.A. Nuijts ◽  
G.W. Daube ◽  
L.H. Koole
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Kinetics Of

scholarly journals Scarless outpatient ablation of pilonidal sinus: a pilot study of a new minimally invasive treatment

2014 ◽  
Vol 13 (5) ◽  
pp. 705-708 ◽  
Author(s):  
Benedetto Neola ◽  
Stefano Capasso ◽  
Luca Caruso ◽  
Armando Falato ◽  
Giuseppe P Ferulano
Keyword(s):  
Pilot Study ◽  
Minimally Invasive ◽  
Pilonidal Sinus ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

Minimally Invasive Treatment for Papillae Deficiencies in the Esthetic Zone: A Pilot Study

2010 ◽  
Vol 12 (1) ◽  
pp. 1-8 ◽  
Author(s):  
William Becker ◽  
Ildor Gabitov ◽  
Misha Stepanov ◽  
John Kois ◽  
Ami Smidt ◽  
...  
Keyword(s):  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment

In Vitro–In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

2018 ◽  
Vol 107 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Angus R. Hibbins ◽  
Mershen Govender ◽  
Sunaina Indermun ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salmon Calcitonin ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device

scholarly journals Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures

2021 ◽  
Vol 7 (1) ◽  
pp. eabd4639
Author(s):  
Hyunwoo Joo ◽  
Youngsik Lee ◽  
Jaemin Kim ◽  
Jeong-Suk Yoo ◽  
Seungwon Yoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Survival Rates ◽  
Animal Experiments ◽  
Wearable Devices ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Novel Treatment ◽  
Medical Emergencies

Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.

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