scholarly journals 131I-Labeled Multifunctional Polyethylenimine/Doxorubicin Complexes with pH-Controlled Cellular Uptake Property for Enhanced SPECT Imaging and Chemo/Radiotherapy of Tumors

2021 ◽  
Vol Volume 16 ◽  
pp. 5167-5183
Author(s):  
Jingyi Zhu ◽  
Junxing Yang ◽  
Lingzhou Zhao ◽  
Pingping Zhao ◽  
Jiqin Yang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Spect Imaging ◽  
Ph Controlled

scholarly journals Photothermal Therapy: Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed-Charge Gold Nanostars (Small 15/2015)

Small ◽  
2015 ◽  
Vol 11 (15) ◽  
pp. 1738-1738 ◽  
Author(s):  
Shouju Wang ◽  
Zhaogang Teng ◽  
Peng Huang ◽  
Dingbin Liu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Photothermal Therapy ◽  
Extracellular Ph ◽  
Gold Nanostars ◽  
Ph Controlled

scholarly journals Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed-Charge Gold Nanostars

Small ◽  
2015 ◽  
Vol 11 (15) ◽  
pp. 1801-1810 ◽  
Author(s):  
Shouju Wang ◽  
Zhaogang Teng ◽  
Peng Huang ◽  
Dingbin Liu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Photothermal Therapy ◽  
Extracellular Ph ◽  
Gold Nanostars ◽  
Ph Controlled

scholarly journals Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 513 ◽  
Author(s):  
Francisco Silva ◽  
António Paulo ◽  
Agnès Pallier ◽  
Sandra Même ◽  
Éva Tóth ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cellular Uptake ◽  
Photon Emission ◽  
Spect Imaging ◽  
Emission Computed Tomography ◽  
Bimodal Imaging ◽  
Biodistribution Studies ◽  
T1 And T2 ◽  
T2 Mri

Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes.

pH/temperature-responsive fluorescence polymer probe with pH-controlled cellular uptake

2015 ◽  
Vol 207 ◽  
pp. 724-731 ◽  
Author(s):  
Yuki Hiruta ◽  
Takaaki Funatsu ◽  
Minami Matsuura ◽  
Jian Wang ◽  
Eri Ayano ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Temperature Responsive ◽  
Ph Controlled

Visualization of size-dependent tumour retention of PEGylated nanographene oxide via SPECT imaging

2016 ◽  
Vol 4 (39) ◽  
pp. 6446-6453 ◽  
Author(s):  
Tianye Cao ◽  
Peihong You ◽  
Xiaobao Zhou ◽  
Jianmin Luo ◽  
Xiaoping Xu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Spect Imaging ◽  
Size Dependent ◽  
Tumor Accumulation

Sub-50 nm usNGO–PEG was confirmed to be the favorable size for faster and higher cellular uptake and efficient tumor accumulation than over-50 nm NGO–PEG.

scholarly journals SPECT Imaging of SST2-Expressing Tumors with 99mTc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers

2021 ◽  
Vol 14 (4) ◽  
pp. 300
Author(s):  
Raghuvir Haridas Gaonkar ◽  
Fabius Wiesmann ◽  
Luigi Del Pozzo ◽  
Lisa McDougall ◽  
Sandra Zanger ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cellular Uptake ◽  
Somatostatin Receptor ◽  
Spect Imaging ◽  
In Vivo Evaluation ◽  
Diagnostic Efficacy ◽  
Biodistribution Studies

[99mTc]Tc-HYNIC-TOC is the most widely used 99mTc-labeled somatostatin receptor (SST) agonist for the SPECT imaging of SST-expressing tumors, such as neuroendocrine tumors. Recently, radiolabeled SST antagonists have shown improved diagnostic efficacy over agonists. 99mTc-labeled SST antagonists are lacking in clinical practice. Surprisingly, when [99mTc]Tc-HYNIC was conjugated to the SST2 antagonist SS01, SST2 imaging was not feasible. This was not the case when [99mTc]Tc-N4 was conjugated to SS01. Here, we assessed the introduction of different spacers (X: β-Ala, Ahx, Aun and PEG4) among HYNIC and SS01 with the aim of restoring the affinity of HYNIC conjugates. In addition, we used the alternative antagonist JR11 for determining the suitability of HYNIC with 99mTc-labeled SST2 antagonists. We performed a head-to-head comparison of the N4 conjugates of SS01 and JR11. [99mTc]Tc-HYNIC-TOC was used as a reference, and HEK-SST2 cells were used for in vitro and in vivo evaluation. EDDA was used as a co-ligand for all [99mTc]Tc-HYNIC conjugates. The introduction of Ahx restored, to a great extent, the SST2-mediated cellular uptake of the [99mTc]Tc-HYNIC-X conjugates (X: spacer), albeit lower than the corresponding [99mTc]Tc-N4-conjugates. SPECT/CT images showed that all 99mTc-labeled conjugates accumulated in the tumor and kidneys with [99mTc]Tc-HYNIC-PEG4-SS01, [99mTc]Tc-N4-SS01 and [99mTc]Tc-N4-JR11 having notably higher kidney uptake. Biodistribution studies showed similar or better tumor-to-non-tumor ratios for the [99mTc]Tc-HYNIC-Ahx conjugates, compared to the [99mTc]Tc-N4 counterparts. The [99mTc]Tc-HYNIC-Ahx conjugates of SS01 and JR11 were comparable to [99mTc]Tc-HYNIC-TOC as imaging agents. HYNIC is a suitable chelator for the development of 99mTc-labeled SST2 antagonists when a spacer of appropriate length, such as Ahx, is used.

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

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