scholarly journals Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed-Charge Gold Nanostars

Small ◽  
2015 ◽  
Vol 11 (15) ◽  
pp. 1801-1810 ◽  
Author(s):  
Shouju Wang ◽  
Zhaogang Teng ◽  
Peng Huang ◽  
Dingbin Liu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Photothermal Therapy ◽  
Extracellular Ph ◽  
Gold Nanostars ◽  
Ph Controlled

scholarly journals Photothermal Therapy: Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed-Charge Gold Nanostars (Small 15/2015)

Small ◽  
2015 ◽  
Vol 11 (15) ◽  
pp. 1738-1738 ◽  
Author(s):  
Shouju Wang ◽  
Zhaogang Teng ◽  
Peng Huang ◽  
Dingbin Liu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Photothermal Therapy ◽  
Extracellular Ph ◽  
Gold Nanostars ◽  
Ph Controlled

Carbon Dot Assemblies for Enhanced Cellular Uptake and Photothermal Therapy In Vitro

2017 ◽  
Vol 2 (33) ◽  
pp. 10860-10864 ◽  
Author(s):  
Changshun Hou ◽  
Mengqi Wang ◽  
Liang Guo ◽  
Qingyan Jia ◽  
Jiechao Ge
Keyword(s):  
Cellular Uptake ◽  
Photothermal Therapy ◽  
Carbon Dot

scholarly journals 131I-Labeled Multifunctional Polyethylenimine/Doxorubicin Complexes with pH-Controlled Cellular Uptake Property for Enhanced SPECT Imaging and Chemo/Radiotherapy of Tumors

2021 ◽  
Vol Volume 16 ◽  
pp. 5167-5183
Author(s):  
Jingyi Zhu ◽  
Junxing Yang ◽  
Lingzhou Zhao ◽  
Pingping Zhao ◽  
Jiqin Yang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Spect Imaging ◽  
Ph Controlled

Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

2016 ◽  
Vol 4 (23) ◽  
pp. 4216-4226 ◽  
Author(s):  
Du Li ◽  
Yongxing Zhang ◽  
Shihui Wen ◽  
Yang Song ◽  
Yueqin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Gold Nanostars

A theranostic nanoplatform for in vivo CT imaging and enhanced PTT of tumors is reported.

Reversion of physiological drug resistance of weakly basic drugs: The discovery of a new mechanism of PEG-PCL nanoparticles

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13528-e13528
Author(s):  
R. Li ◽  
L. Xie ◽  
X. Li ◽  
Q. Liu ◽  
X. Qian ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Antitumor Effect ◽  
In Vitro Cytotoxicity ◽  
Extracellular Ph ◽  
Fluorescent Particle ◽  
Tumor Ph

e13528 Background: A number of studies have reported the superior antitumor effect of nanoparticles loading chemotherapeutics than the free agents, yet the underlying mechanism has not attract enough attention. The extracellular pH of cancer cells is lower than that of the intracellular pH. Due to this pH gradient, weakly basic drug will protonated extracellularly and display decreased intracellular concentration. In this study, we aimed to reveal a new mechanism of PEG-PCL nanoparticles, namely the reversion of physiological drug resistance. Methods: Tetradrine (Tet), an alkaloid isolated from traditional Chinese medicine, was incorporated into the diblock copolymer methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL). In vitro cytotoxicity of free Tet and Tet-loaded nanoparticles at pH7.4 and pH6.8 was compared on four different cancer cell lines. Fluorescent particle cellular uptake study was also used. To evaluate the antitumor effect of the nanoparticles in a more complex model rather than monolayer cell culture, we used Histoculture Drug Resistance Assay (HDRA). The in vivo antitumor effect of the nanoparticles was also studied in ICR mice bearing H22 tumor with different in vivo pH values. Results: In vitro cytotoxicity study in four tumor cell lines showed that the cytotoxicity of free Tet decreased significantly (P<0.05) when the extracellular pH decreased from 7.4 to 6.8, while the cytotoxicity of Tet-loaded nanoparticles increased or didn’t change significantly. The possible mechanism may mainly be the endocytosis of nanoparticles, which was proven by fluorescent particle cellular uptake study. HDRA indicated better tissue penetration of nanoparticles over free Tet. As to in vivo study, the mice with in vivo tumor pH 6.8 and treated with Tet-loaded nanoparticles exhibited best tumor inhibit rate and mildest side effect, suggesting that the use of nanoparticles was more preferable than the manipulation of tumor pH by the use of basic water. Conclusions: Our study clearly demonstrated that the mPEG-PCL nanoparticles could overcome the drug resistance caused by low extracellular pH and enhance drug penetration in the tumor tissue, thus increasing the antitumor efficacy of weakly basic agents. No significant financial relationships to disclose.

Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids

2018 ◽  
Vol 39 (3) ◽  
pp. 280-286 ◽  
Author(s):  
吴 頔 WU Di ◽  
樊 淼 FAN Miao ◽  
张露云 ZHANG Lu-yun ◽  
邢晶晶 XING Jing-jing ◽  
吕树芳 LYU Shu-fang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Controllable Synthesis ◽  
Photothermal Conversion ◽  
Gold Nanostars
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